| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK8 | IRS1 | Ser315 | ITATSPAsMVGGKPG | phosphorylation down-regulates | 12510059 | SIGNOR-96940 |
| MTOR | IRS1 | Ser315 | ITATSPAsMVGGKPG | phosphorylation down-regulates activity | 11287630 | SIGNOR-106578 |
| MAPK9 | IRS1 | Ser315 | ITATSPAsMVGGKPG | phosphorylation down-regulates | 9335553 | SIGNOR-52696 |
| MAPK8 | IRS1 | Ser315 | ITATSPAsMVGGKPG | phosphorylation down-regulates | 14579029 | SIGNOR-118861 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK8 | phosphorylation up-regulates → | IRS1 PSer315 | phosphorylation down-regulates ⊣ | IRS1 | 12510059 | SIGNOR-96940 |
| MTOR | phosphorylation up-regulates → | IRS1 PSer315 | phosphorylation down-regulates ⊣ | IRS1 | 11287630 | SIGNOR-106578 |
| MAPK9 | phosphorylation up-regulates → | IRS1 PSer315 | phosphorylation down-regulates ⊣ | IRS1 | 9335553 | SIGNOR-52696 |
| MAPK8 | phosphorylation up-regulates → | IRS1 PSer315 | phosphorylation down-regulates ⊣ | IRS1 | 14579029 | SIGNOR-118861 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK8 | phosphorylation down-regulates | IRS1 | SIGNOR-96940 |
| MTOR | phosphorylation → down-regulates activity | IRS1 | SIGNOR-106578 |
| MAPK9 | phosphorylation down-regulates | IRS1 | SIGNOR-52696 |
| MAPK8 | phosphorylation down-regulates | IRS1 | SIGNOR-118861 |
