| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCZ | IRS1 | Ser323 | MVGGKPGsFRVRASS | phosphorylation down-regulates | 15069075 | SIGNOR-123738 |
| PRKCD | IRS1 | Ser323 | MVGGKPGsFRVRASS | phosphorylation down-regulates | 15069075 | SIGNOR-123734 |
| PRKCD | IRS1 | Ser323 | MVGGKPGsFRVRASS | phosphorylation down-regulates | 16611834 | SIGNOR-146105 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCZ | phosphorylation up-regulates → | IRS1 PSer323 | phosphorylation down-regulates ⊣ | IRS1 | 15069075 | SIGNOR-123738 |
| PRKCD | phosphorylation up-regulates → | IRS1 PSer323 | phosphorylation down-regulates ⊣ | IRS1 | 15069075 | SIGNOR-123734 |
| PRKCD | phosphorylation up-regulates → | IRS1 PSer323 | phosphorylation down-regulates ⊣ | IRS1 | 16611834 | SIGNOR-146105 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKCZ | phosphorylation down-regulates | IRS1 | SIGNOR-123738 |
| PRKCD | phosphorylation down-regulates | IRS1 | SIGNOR-123734 |
| PRKCD | phosphorylation down-regulates | IRS1 | SIGNOR-146105 |
