| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCZ | IRS1 | Ser307 | TRRSRTEsITATSPA | phosphorylation down-regulates activity | 15069075 | SIGNOR-236760 |
| RPS6KB1 | IRS1 | Ser307 | TRRSRTEsITATSPA | phosphorylation down-regulates activity | 15306821 | SIGNOR-127908 |
| MEK1/2 | IRS1 | Ser307 | TRRSRTEsITATSPA | phosphorylation down-regulates | 11160134 | SIGNOR-244784 |
| IKBKB | IRS1 | Ser307 | TRRSRTEsITATSPA | phosphorylation down-regulates activity | 12351658 | SIGNOR-251292 |
| MTOR | IRS1 | Ser307 | TRRSRTEsITATSPA | phosphorylation down-regulates activity | 11287630 | SIGNOR-106570 |
| MAPK9 | IRS1 | Ser307 | TRRSRTEsITATSPA | phosphorylation down-regulates | 14579029 | SIGNOR-118881 |
| MAP2K1 | IRS1 | Ser307 | TRRSRTEsITATSPA | phosphorylation down-regulates | 11160134 | SIGNOR-236611 |
| PTEN | IRS1 | Ser307 | TRRSRTEsITATSPA | dephosphorylation down-regulates activity | 25645159 | SIGNOR-277078 |
| MTOR | IRS1 | Ser307 | TRRSRTEsITATSPA | phosphorylation down-regulates activity | 9335553 | SIGNOR-52700 |
| MAPK8 | IRS1 | Ser307 | TRRSRTEsITATSPA | phosphorylation down-regulates | 14579029 | SIGNOR-118857 |
| MAPK8 | IRS1 | Ser307 | TRRSRTEsITATSPA | phosphorylation down-regulates | 12510059 | SIGNOR-96936 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCZ | phosphorylation up-regulates → | IRS1 PSer307 | phosphorylation down-regulates ⊣ | IRS1 | 15069075 | SIGNOR-236760 |
| RPS6KB1 | phosphorylation up-regulates → | IRS1 PSer307 | phosphorylation down-regulates ⊣ | IRS1 | 15306821 | SIGNOR-127908 |
| MEK1/2 | phosphorylation up-regulates → | IRS1 PSer307 | phosphorylation down-regulates ⊣ | IRS1 | 11160134 | SIGNOR-244784 |
| IKBKB | phosphorylation up-regulates → | IRS1 PSer307 | phosphorylation down-regulates ⊣ | IRS1 | 12351658 | SIGNOR-251292 |
| MTOR | phosphorylation up-regulates → | IRS1 PSer307 | phosphorylation down-regulates ⊣ | IRS1 | 11287630 | SIGNOR-106570 |
| MAPK9 | phosphorylation up-regulates → | IRS1 PSer307 | phosphorylation down-regulates ⊣ | IRS1 | 14579029 | SIGNOR-118881 |
| MAP2K1 | phosphorylation up-regulates → | IRS1 PSer307 | phosphorylation down-regulates ⊣ | IRS1 | 11160134 | SIGNOR-236611 |
| PTEN | dephosphorylation down-regulates ⊣ | IRS1 PSer307 | dephosphorylation up-regulates → | IRS1 | 25645159 | SIGNOR-277078 |
| MTOR | phosphorylation up-regulates → | IRS1 PSer307 | phosphorylation down-regulates ⊣ | IRS1 | 9335553 | SIGNOR-52700 |
| MAPK8 | phosphorylation up-regulates → | IRS1 PSer307 | phosphorylation down-regulates ⊣ | IRS1 | 14579029 | SIGNOR-118857 |
| MAPK8 | phosphorylation up-regulates → | IRS1 PSer307 | phosphorylation down-regulates ⊣ | IRS1 | 12510059 | SIGNOR-96936 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKCZ | phosphorylation → down-regulates activity | IRS1 | SIGNOR-236760 |
| RPS6KB1 | phosphorylation → down-regulates activity | IRS1 | SIGNOR-127908 |
| MEK1/2 | phosphorylation down-regulates | IRS1 | SIGNOR-244784 |
| IKBKB | phosphorylation → down-regulates activity | IRS1 | SIGNOR-251292 |
| MTOR | phosphorylation → down-regulates activity | IRS1 | SIGNOR-106570 |
| MAPK9 | phosphorylation down-regulates | IRS1 | SIGNOR-118881 |
| MAP2K1 | phosphorylation down-regulates | IRS1 | SIGNOR-236611 |
| PTEN | dephosphorylation → down-regulates activity | IRS1 | SIGNOR-277078 |
| MTOR | phosphorylation → down-regulates activity | IRS1 | SIGNOR-52700 |
| MAPK8 | phosphorylation down-regulates | IRS1 | SIGNOR-118857 |
| MAPK8 | phosphorylation down-regulates | IRS1 | SIGNOR-96936 |
