| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| IGF1R | IRS1 | Tyr1179 | GLENGLNyIDLDLVK | phosphorylation up-regulates | 17827393 | SIGNOR-157730 |
| PTPN11 | IRS1 | Tyr1179 | GLENGLNyIDLDLVK | dephosphorylation down-regulates | 10660596 | SIGNOR-74856 |
| PTPN11 | IRS1 | Tyr1179 | GLENGLNyIDLDLVK | dephosphorylation down-regulates | 7515062 | SIGNOR-27024 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| IGF1R | phosphorylation up-regulates → | IRS1 PTyr1179 | phosphorylation up-regulates → | IRS1 | 17827393 | SIGNOR-157730 |
| PTPN11 | dephosphorylation down-regulates ⊣ | IRS1 PTyr1179 | dephosphorylation up-regulates → | IRS1 | 10660596 | SIGNOR-74856 |
| PTPN11 | dephosphorylation down-regulates ⊣ | IRS1 PTyr1179 | dephosphorylation up-regulates → | IRS1 | 7515062 | SIGNOR-27024 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| IGF1R | phosphorylation → up-regulates | IRS1 | SIGNOR-157730 |
| PTPN11 | dephosphorylation down-regulates | IRS1 | SIGNOR-74856 |
| PTPN11 | dephosphorylation down-regulates | IRS1 | SIGNOR-27024 |
