| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| IKBKB | IRS1 | Ser270 | EFRPRSKsQSSSNCS | phosphorylation down-regulates activity | 12351658 | SIGNOR-251289 |
| RPS6KB1 | IRS1 | Ser270 | EFRPRSKsQSSSNCS | phosphorylation down-regulates activity | 9312143 | SIGNOR-51216 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| IKBKB | phosphorylation up-regulates → | IRS1 PSer270 | phosphorylation down-regulates ⊣ | IRS1 | 12351658 | SIGNOR-251289 |
| RPS6KB1 | phosphorylation up-regulates → | IRS1 PSer270 | phosphorylation down-regulates ⊣ | IRS1 | 9312143 | SIGNOR-51216 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| IKBKB | phosphorylation → down-regulates activity | IRS1 | SIGNOR-251289 |
| RPS6KB1 | phosphorylation → down-regulates activity | IRS1 | SIGNOR-51216 |