Entity Details

Name RPS6KB1_Ser639
ID P35568
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
RPS6KB1IRS1Ser639YMPMSPKsVSAPQQIphosphorylation
down-regulates quantity by destabilization		18498745SIGNOR-236599
MTORIRS1Ser639YMPMSPKsVSAPQQIphosphorylation
down-regulates activity		11287630SIGNOR-106590
RPS6KB1IRS1Ser639YMPMSPKsVSAPQQIphosphorylation
down-regulates activity		15306821SIGNOR-127203
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
RPS6KB1phosphorylation
up-regulates
→
IRS1
PSer639		phosphorylation
down-regulates
⊣		IRS118498745SIGNOR-236599
MTORphosphorylation
up-regulates
→
IRS1
PSer639		phosphorylation
down-regulates
⊣		IRS111287630SIGNOR-106590
RPS6KB1phosphorylation
up-regulates
→
IRS1
PSer639		phosphorylation
down-regulates
⊣		IRS115306821SIGNOR-127203
Regulator Mechanism/Effect Target SIGNOR-ID
RPS6KB1phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		IRS1SIGNOR-236599
MTORphosphorylation
→
down-regulates activity 		IRS1SIGNOR-106590
RPS6KB1phosphorylation
→
down-regulates activity 		IRS1SIGNOR-127203