| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SIK2 | IRS1 | Ser794 | QHLRLSTsSGRLLYA | phosphorylation unknown | 12624099 | SIGNOR-99055 |
| SIK2 | IRS1 | Ser794 | QHLRLSTsSGRLLYA | phosphorylation unknown | 12624099 | SIGNOR-99059 |
| SIK2 | IRS1 | Ser794 | QHLRLSTsSGRLLYA | phosphorylation down-regulates quantity | 24841198 | SIGNOR-265745 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SIK2 | phosphorylation up-regulates → | IRS1 PSer794 | phosphorylation down-regulates ⊣ | IRS1 | 12624099 | SIGNOR-99055 |
| SIK2 | phosphorylation up-regulates → | IRS1 PSer794 | phosphorylation down-regulates ⊣ | IRS1 | 12624099 | SIGNOR-99059 |
| SIK2 | phosphorylation up-regulates → | IRS1 PSer794 | phosphorylation down-regulates ⊣ | IRS1 | 24841198 | SIGNOR-265745 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| SIK2 | phosphorylation → unknown | IRS1 | SIGNOR-99055 |
| SIK2 | phosphorylation → unknown | IRS1 | SIGNOR-99059 |
| SIK2 | phosphorylation → down-regulates quantity | IRS1 | SIGNOR-265745 |
