| Name | FLT3 |
| ID | P36888 |
| Role | kinase |
| Enzymatic Domains |
Ig-like C2-type 253-343
Protein kinase 610-943 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| FLT3 | ACAT1 | Tyr407 | HALKQGEyGLASICN | phosphorylation up-regulates activity | 34289383 | SIGNOR-267628 |
| FLT3 | SHC1 | – | phosphorylation up-regulates activity | 15769897 | SIGNOR-261540 | |
| FLT3 | FLT3 | Tyr589 | TGSSDNEyFYVDFRE | phosphorylation up-regulates | 11971190 | SIGNOR-117571 |
| FLT3 | FLT3 | Tyr591 | SSDNEYFyVDFREYE | phosphorylation up-regulates activity | 16627759 | SIGNOR-271921 |
| FLT3 | CTNNB1 | – | phosphorylation up-regulates activity | 17851558 | SIGNOR-260124 | |
| FLT3 | FLT3 | Tyr599 | VDFREYEyDLKWEFP | phosphorylation up-regulates | 11971190 | SIGNOR-117583 |
| FLT3 | SIRT3 | Tyr226 | KGLLLRLyTQNIDGL | phosphorylation down-regulates activity | 34289383 | SIGNOR-267631 |
| FLT3 | FLT3 | Tyr842 | DIMSDSNyVVRGNAR | phosphorylation up-regulates activity | 16627759 | SIGNOR-271925 |
| FLT3 | FLT3 | Tyr597 | FYVDFREyEYDLKWE | phosphorylation up-regulates | 11971190 | SIGNOR-117579 |
| FLT3 | STAT5A | Tyr694 | LAKAVDGyVKPQIKQ | phosphorylation up-regulates activity | 17356133 | SIGNOR-245069 |
| FLT3 | FLT3 | Tyr589 | TGSSDNEyFYVDFRE | phosphorylation up-regulates activity | 16627759 | SIGNOR-271926 |
| FLT3 | FLT3 | Tyr969 | VSECPHTyQNRRPFS | phosphorylation unknown | 16627759 | SIGNOR-271920 |
| FLT3 | CDKN1B | Tyr88 | KGSLPEFyYRPPRPP | phosphorylation down-regulates activity | 28522571 | SIGNOR-269208 |
| FLT3 | AKT | – | phosphorylation up-regulates activity | 14981546 | SIGNOR-261522 | |
| FLT3 | SHC1 | Tyr349 | EEPPDHQyYNDFPGK | phosphorylation up-regulates activity | 10482988 | SIGNOR-251146 |
| FLT3 | FLT3 | Tyr842 | DIMSDSNyVVRGNAR | phosphorylation unknown | 28271164 | SIGNOR-271924 |
| FLT3 | IDH2 | Tyr107 | SALATQKySVAVKCA | phosphorylation down-regulates activity | 34289383 | SIGNOR-267632 |
| FLT3 | SHC1 | Tyr350 | EPPDHQYyNDFPGKE | phosphorylation up-regulates activity | 10482988 | SIGNOR-251147 |
| FLT3 | IDH1 | Tyr42 | VELDLHSyDLGIENR | phosphorylation up-regulates activity | 34289383 | SIGNOR-267629 |
| FLT3 | FLT3 | Tyr955 | ADAEEAMyQNVDGRV | phosphorylation unknown | 16627759 | SIGNOR-271923 |
| FLT3 | SHC1 | Tyr427 | ELFDDPSyVNVQNLD | phosphorylation up-regulates activity | 10482988 | SIGNOR-251148 |
| FLT3 | FLT3 | Tyr726 | KEHNFSFyPTFQSHP | phosphorylation unknown | 16627759 | SIGNOR-271922 |
| FLT3 | IDH1 | Tyr391 | PNVQRSDyLNTFEFM | phosphorylation up-regulates activity | 34289383 | SIGNOR-267630 |
| FLT3 | FLT3 | Tyr591 | SSDNEYFyVDFREYE | phosphorylation up-regulates | 11971190 | SIGNOR-117575 |
| FLT3 | STAT5A | – | phosphorylation up-regulates activity | 12796379 | SIGNOR-261516 | |
| FLT3 | FLT3 | Tyr969 | VSECPHTyQNRRPFS | phosphorylation up-regulates activity | 31395582 | SIGNOR-271919 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| FLT3 | phosphorylation up-regulates → | ACAT1 PTyr407 | phosphorylation up-regulates → | ACAT1 | 34289383 | SIGNOR-267628 |
| FLT3 | phosphorylation up-regulates → | FLT3 PTyr589 | phosphorylation up-regulates → | FLT3 | 11971190 | SIGNOR-117571 |
| FLT3 | phosphorylation up-regulates → | FLT3 PTyr591 | phosphorylation up-regulates → | FLT3 | 16627759 | SIGNOR-271921 |
| FLT3 | phosphorylation up-regulates → | FLT3 PTyr599 | phosphorylation up-regulates → | FLT3 | 11971190 | SIGNOR-117583 |
| FLT3 | phosphorylation up-regulates → | SIRT3 PTyr226 | phosphorylation down-regulates ⊣ | SIRT3 | 34289383 | SIGNOR-267631 |
| FLT3 | phosphorylation up-regulates → | FLT3 PTyr842 | phosphorylation up-regulates → | FLT3 | 16627759 | SIGNOR-271925 |
| FLT3 | phosphorylation up-regulates → | FLT3 PTyr597 | phosphorylation up-regulates → | FLT3 | 11971190 | SIGNOR-117579 |
| FLT3 | phosphorylation up-regulates → | STAT5A PTyr694 | phosphorylation up-regulates → | STAT5A | 17356133 | SIGNOR-245069 |
| FLT3 | phosphorylation up-regulates → | FLT3 PTyr589 | phosphorylation up-regulates → | FLT3 | 16627759 | SIGNOR-271926 |
| FLT3 | phosphorylation up-regulates → | FLT3 PTyr969 | phosphorylation down-regulates ⊣ | FLT3 | 16627759 | SIGNOR-271920 |
| FLT3 | phosphorylation up-regulates → | CDKN1B PTyr88 | phosphorylation down-regulates ⊣ | CDKN1B | 28522571 | SIGNOR-269208 |
| FLT3 | phosphorylation up-regulates → | SHC1 PTyr349 | phosphorylation up-regulates → | SHC1 | 10482988 | SIGNOR-251146 |
| FLT3 | phosphorylation up-regulates → | FLT3 PTyr842 | phosphorylation down-regulates ⊣ | FLT3 | 28271164 | SIGNOR-271924 |
| FLT3 | phosphorylation up-regulates → | IDH2 PTyr107 | phosphorylation down-regulates ⊣ | IDH2 | 34289383 | SIGNOR-267632 |
| FLT3 | phosphorylation up-regulates → | SHC1 PTyr350 | phosphorylation up-regulates → | SHC1 | 10482988 | SIGNOR-251147 |
| FLT3 | phosphorylation up-regulates → | IDH1 PTyr42 | phosphorylation up-regulates → | IDH1 | 34289383 | SIGNOR-267629 |
| FLT3 | phosphorylation up-regulates → | FLT3 PTyr955 | phosphorylation down-regulates ⊣ | FLT3 | 16627759 | SIGNOR-271923 |
| FLT3 | phosphorylation up-regulates → | SHC1 PTyr427 | phosphorylation up-regulates → | SHC1 | 10482988 | SIGNOR-251148 |
| FLT3 | phosphorylation up-regulates → | FLT3 PTyr726 | phosphorylation down-regulates ⊣ | FLT3 | 16627759 | SIGNOR-271922 |
| FLT3 | phosphorylation up-regulates → | IDH1 PTyr391 | phosphorylation up-regulates → | IDH1 | 34289383 | SIGNOR-267630 |
| FLT3 | phosphorylation up-regulates → | FLT3 PTyr591 | phosphorylation up-regulates → | FLT3 | 11971190 | SIGNOR-117575 |
| FLT3 | phosphorylation up-regulates → | FLT3 PTyr969 | phosphorylation up-regulates → | FLT3 | 31395582 | SIGNOR-271919 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| FLT3 | phosphorylation → up-regulates activity | ACAT1 | SIGNOR-267628 |
| FLT3 | phosphorylation → up-regulates activity | SHC1 | SIGNOR-261540 |
| FLT3 | phosphorylation → up-regulates | FLT3 | SIGNOR-117571 |
| FLT3 | phosphorylation → up-regulates activity | FLT3 | SIGNOR-271921 |
| FLT3 | phosphorylation → up-regulates activity | CTNNB1 | SIGNOR-260124 |
| FLT3 | phosphorylation → up-regulates | FLT3 | SIGNOR-117583 |
| FLT3 | phosphorylation → down-regulates activity | SIRT3 | SIGNOR-267631 |
| FLT3 | phosphorylation → up-regulates activity | FLT3 | SIGNOR-271925 |
| FLT3 | phosphorylation → up-regulates | FLT3 | SIGNOR-117579 |
| FLT3 | phosphorylation → up-regulates activity | STAT5A | SIGNOR-245069 |
| FLT3 | phosphorylation → up-regulates activity | FLT3 | SIGNOR-271926 |
| FLT3 | phosphorylation → unknown | FLT3 | SIGNOR-271920 |
| FLT3 | phosphorylation → down-regulates activity | CDKN1B | SIGNOR-269208 |
| FLT3 | phosphorylation → up-regulates activity | AKT | SIGNOR-261522 |
| FLT3 | phosphorylation → up-regulates activity | SHC1 | SIGNOR-251146 |
| FLT3 | phosphorylation → unknown | FLT3 | SIGNOR-271924 |
| FLT3 | phosphorylation → down-regulates activity | IDH2 | SIGNOR-267632 |
| FLT3 | phosphorylation → up-regulates activity | SHC1 | SIGNOR-251147 |
| FLT3 | phosphorylation → up-regulates activity | IDH1 | SIGNOR-267629 |
| FLT3 | phosphorylation → unknown | FLT3 | SIGNOR-271923 |
| FLT3 | phosphorylation → up-regulates activity | SHC1 | SIGNOR-251148 |
| FLT3 | phosphorylation → unknown | FLT3 | SIGNOR-271922 |
| FLT3 | phosphorylation → up-regulates activity | IDH1 | SIGNOR-267630 |
| FLT3 | phosphorylation → up-regulates | FLT3 | SIGNOR-117575 |
| FLT3 | phosphorylation → up-regulates activity | STAT5A | SIGNOR-261516 |
| FLT3 | phosphorylation → up-regulates activity | FLT3 | SIGNOR-271919 |