Summary

Name FLT3
Full Name Receptor-type tyrosine-protein kinase FLT3
Synonyms FL cytokine receptor, Fetal liver kinase-2, FLK-2, Fms-like tyrosine kinase 3, FLT-3, Stem cell tyrosine kinase 1, STK-1 | CD135, FLK2, STK1
Primary ID P36888
Links - -
Type protein
Relations 35
Pathways Acute Myeloid Leukemia, AML-FLT3, AML_miRNA
Inhibitors Sunitinib malate; Quizartinib; Tandutinib; CHIR-124; TG101209; Dovitinib; 1,9-Pyrazoloanthrone; MK-2461; dovitinib; bis(lactic acid); KW-2449; quizartinib
Function Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation SHC1
Publications: 3 Organism: Homo Sapiens
Pathways:AML_miRNA
+ up-regulates img/direct-activation.png phosphorylation FLT3
Publications: 4 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, AML-FLT3, AML_miRNA
+ up-regulates activity img/direct-activation.png phosphorylation STAT5A
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, AML-FLT3, AML_miRNA
+ down-regulates img/direct_inhibition.png chemical inhibition FLT3
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding FLT3
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, AML-FLT3
+ down-regulates img/direct_inhibition.png chemical inhibition FLT3
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition FLT3
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition FLT3
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition FLT3
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png unknown AKT
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, AML-FLT3
+ down-regulates img/direct_inhibition.png chemical inhibition FLT3
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown Skeletal Muscle Differentiation
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ down-regulates img/direct_inhibition.png chemical inhibition FLT3
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation CEBPB 0.05
Publications: 1
+ down-regulates img/direct_inhibition.png chemical inhibition FLT3
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition FLT3
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GRB2
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, AML-FLT3
+ up-regulates activity img/direct-activation.png binding PTPN11
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, AML-FLT3
+ up-regulates quantity by expression img/indirect-activation.png transcriptional activation ID1 0.09
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, AML-FLT3, AML_miRNA
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation miR-155
Publications: 1 Organism: Homo Sapiens
Pathways:AML_miRNA
+ down-regulates activity img/direct_inhibition.png binding FLT3 0.23
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, AML-FLT3
+ down-regulates img/direct_inhibition.png chemical inhibition FLT3
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation SPI1 0.03
Publications: 1
Pathways:Acute Myeloid Leukemia, AML_miRNA
+ up-regulates activity img/indirect-activation.png unknown AKT1 0.10
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GRB10
Publications: 1 Organism: Mus Musculus
Pathways:AML-FLT3
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation CEBPA
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, AML-FLT3
+ down-regulates activity img/direct_inhibition.png chemical inhibition FLT3
Publications: 1 Organism: In Vitro