| Name | FLT3 |
| ID | P36888 |
| Role | substrate |
| Enzymatic Domains |
Ig-like C2-type 253-343
Protein kinase 610-943 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SYK | FLT3 | Tyr768 | HSEDEIEyENQKRLE | phosphorylation up-regulates activity | 24525236 | SIGNOR-278431 |
| FYN | FLT3 | – | phosphorylation up-regulates activity | 26848862 | SIGNOR-279715 | |
| FLT3 | FLT3 | Tyr842 | DIMSDSNyVVRGNAR | phosphorylation unknown | 28271164 | SIGNOR-271924 |
| PIM1 | FLT3 | Tyr591 | SSDNEYFyVDFREYE | phosphorylation up-regulates quantity | 24040307 | SIGNOR-259927 |
| SYK | FLT3 | Tyr955 | ADAEEAMyQNVDGRV | phosphorylation up-regulates activity | 24525236 | SIGNOR-278430 |
| FLT3 | FLT3 | Tyr955 | ADAEEAMyQNVDGRV | phosphorylation unknown | 16627759 | SIGNOR-271923 |
| PTPRJ | FLT3 | – | dephosphorylation down-regulates activity | 21262971 | SIGNOR-277092 | |
| FLT3 | FLT3 | Tyr726 | KEHNFSFyPTFQSHP | phosphorylation unknown | 16627759 | SIGNOR-271922 |
| FLT3 | FLT3 | Tyr591 | SSDNEYFyVDFREYE | phosphorylation up-regulates | 11971190 | SIGNOR-117575 |
| FLT3 | FLT3 | Tyr969 | VSECPHTyQNRRPFS | phosphorylation up-regulates activity | 31395582 | SIGNOR-271919 |
| FLT3 | FLT3 | Tyr589 | TGSSDNEyFYVDFRE | phosphorylation up-regulates | 11971190 | SIGNOR-117571 |
| FLT3 | FLT3 | Tyr591 | SSDNEYFyVDFREYE | phosphorylation up-regulates activity | 16627759 | SIGNOR-271921 |
| FLT3 | FLT3 | Tyr599 | VDFREYEyDLKWEFP | phosphorylation up-regulates | 11971190 | SIGNOR-117583 |
| FLT3 | FLT3 | Tyr842 | DIMSDSNyVVRGNAR | phosphorylation up-regulates activity | 16627759 | SIGNOR-271925 |
| FLT3 | FLT3 | Tyr597 | FYVDFREyEYDLKWE | phosphorylation up-regulates | 11971190 | SIGNOR-117579 |
| FLT3 | FLT3 | Tyr589 | TGSSDNEyFYVDFRE | phosphorylation up-regulates activity | 16627759 | SIGNOR-271926 |
| FLT3 | FLT3 | Tyr969 | VSECPHTyQNRRPFS | phosphorylation unknown | 16627759 | SIGNOR-271920 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SYK | phosphorylation up-regulates → | FLT3 PTyr768 | phosphorylation up-regulates → | FLT3 | 24525236 | SIGNOR-278431 |
| FLT3 | phosphorylation up-regulates → | FLT3 PTyr842 | phosphorylation down-regulates ⊣ | FLT3 | 28271164 | SIGNOR-271924 |
| PIM1 | phosphorylation up-regulates → | FLT3 PTyr591 | phosphorylation up-regulates → | FLT3 | 24040307 | SIGNOR-259927 |
| SYK | phosphorylation up-regulates → | FLT3 PTyr955 | phosphorylation up-regulates → | FLT3 | 24525236 | SIGNOR-278430 |
| FLT3 | phosphorylation up-regulates → | FLT3 PTyr955 | phosphorylation down-regulates ⊣ | FLT3 | 16627759 | SIGNOR-271923 |
| FLT3 | phosphorylation up-regulates → | FLT3 PTyr726 | phosphorylation down-regulates ⊣ | FLT3 | 16627759 | SIGNOR-271922 |
| FLT3 | phosphorylation up-regulates → | FLT3 PTyr591 | phosphorylation up-regulates → | FLT3 | 11971190 | SIGNOR-117575 |
| FLT3 | phosphorylation up-regulates → | FLT3 PTyr969 | phosphorylation up-regulates → | FLT3 | 31395582 | SIGNOR-271919 |
| FLT3 | phosphorylation up-regulates → | FLT3 PTyr589 | phosphorylation up-regulates → | FLT3 | 11971190 | SIGNOR-117571 |
| FLT3 | phosphorylation up-regulates → | FLT3 PTyr591 | phosphorylation up-regulates → | FLT3 | 16627759 | SIGNOR-271921 |
| FLT3 | phosphorylation up-regulates → | FLT3 PTyr599 | phosphorylation up-regulates → | FLT3 | 11971190 | SIGNOR-117583 |
| FLT3 | phosphorylation up-regulates → | FLT3 PTyr842 | phosphorylation up-regulates → | FLT3 | 16627759 | SIGNOR-271925 |
| FLT3 | phosphorylation up-regulates → | FLT3 PTyr597 | phosphorylation up-regulates → | FLT3 | 11971190 | SIGNOR-117579 |
| FLT3 | phosphorylation up-regulates → | FLT3 PTyr589 | phosphorylation up-regulates → | FLT3 | 16627759 | SIGNOR-271926 |
| FLT3 | phosphorylation up-regulates → | FLT3 PTyr969 | phosphorylation down-regulates ⊣ | FLT3 | 16627759 | SIGNOR-271920 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| SYK | phosphorylation → up-regulates activity | FLT3 | SIGNOR-278431 |
| FYN | phosphorylation → up-regulates activity | FLT3 | SIGNOR-279715 |
| FLT3 | phosphorylation → unknown | FLT3 | SIGNOR-271924 |
| PIM1 | phosphorylation → up-regulates quantity | FLT3 | SIGNOR-259927 |
| SYK | phosphorylation → up-regulates activity | FLT3 | SIGNOR-278430 |
| FLT3 | phosphorylation → unknown | FLT3 | SIGNOR-271923 |
| PTPRJ | dephosphorylation → down-regulates activity | FLT3 | SIGNOR-277092 |
| FLT3 | phosphorylation → unknown | FLT3 | SIGNOR-271922 |
| FLT3 | phosphorylation → up-regulates | FLT3 | SIGNOR-117575 |
| FLT3 | phosphorylation → up-regulates activity | FLT3 | SIGNOR-271919 |
| FLT3 | phosphorylation → up-regulates | FLT3 | SIGNOR-117571 |
| FLT3 | phosphorylation → up-regulates activity | FLT3 | SIGNOR-271921 |
| FLT3 | phosphorylation → up-regulates | FLT3 | SIGNOR-117583 |
| FLT3 | phosphorylation → up-regulates activity | FLT3 | SIGNOR-271925 |
| FLT3 | phosphorylation → up-regulates | FLT3 | SIGNOR-117579 |
| FLT3 | phosphorylation → up-regulates activity | FLT3 | SIGNOR-271926 |
| FLT3 | phosphorylation → unknown | FLT3 | SIGNOR-271920 |