| Name | SREBF1 |
| ID | P36956 |
| Role | substrate |
| Enzymatic Domains |
bHLH 323-373 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | SREBF1 | Thr426 | TEVEDTLtPPPSDAG | phosphorylation down-regulates quantity by destabilization | 16825193 | SIGNOR-236649 |
| PRKACA | SREBF1 | Ser338 | IEKRYRSsINDKIIE | phosphorylation down-regulates | 16381800 | SIGNOR-143392 |
| PRKAA2 | SREBF1 | Ser396 | TAVHKSKsLKDLVSA | phosphorylation down-regulates | 21459323 | SIGNOR-173031 |
| ERK1/2 | SREBF1 | Ser117 | YPSMPAFsPGPGIKE | phosphorylation up-regulates | 10915800 | SIGNOR-244754 |
| MAPK3 | SREBF1 | Ser117 | YPSMPAFsPGPGIKE | phosphorylation up-regulates activity | 10915800 | SIGNOR-80096 |
| GSK3B | SREBF1 | Ser434 | PPPSDAGsPFQSSPL | phosphorylation down-regulates quantity by destabilization | 19126544 | SIGNOR-235797 |
| MAPK1 | SREBF1 | Ser117 | YPSMPAFsPGPGIKE | phosphorylation up-regulates | 10915800 | SIGNOR-80092 |
| CDK1 | SREBF1 | Ser439 | AGSPFQSsPLSLGSR | phosphorylation up-regulates | 16880739 | SIGNOR-148354 |
| PRKAA1 | SREBF1 | – | phosphorylation down-regulates activity | 21892142 | SIGNOR-176497 | |
| RPS6KB1 | SREBF1 | – | phosphorylation up-regulates activity | 33240877 | SIGNOR-280120 | |
| GSK3B | SREBF1 | Thr426 | TEVEDTLtPPPSDAG | phosphorylation down-regulates quantity by destabilization | 19126544 | SIGNOR-236667 |
| PLK1 | SREBF1 | Ser486 | SRGMLDRsRLALCTL | phosphorylation up-regulates activity | 27579997 | SIGNOR-279383 |
| CyclinB/CDK1 | SREBF1 | Ser439 | AGSPFQSsPLSLGSR | phosphorylation up-regulates | 16880739 | SIGNOR-216821 |
| CDK8 | SREBF1 | Thr426 | TEVEDTLtPPPSDAG | phosphorylation up-regulates activity | 23562092 | SIGNOR-279688 |
| PLK1 | SREBF1 | Ser467 | DSPVFEDsKAKPEQR | phosphorylation up-regulates activity | 27579997 | SIGNOR-279382 |
| GSK3B | SREBF1 | Ser430 | DTLTPPPsDAGSPFQ | phosphorylation down-regulates quantity by destabilization | 16825193 | SIGNOR-236645 |
| AMPK | SREBF1 | – | phosphorylation down-regulates | 21892142 | SIGNOR-216564 | |
| GSK3B | SREBF1 | Ser430 | DTLTPPPsDAGSPFQ | phosphorylation down-regulates quantity by destabilization | 19126544 | SIGNOR-236030 |
| AMPK | SREBF1 | Ser396 | TAVHKSKsLKDLVSA | phosphorylation down-regulates | 21459323 | SIGNOR-216533 |
| PLK1 | SREBF1 | Thr424 | VKTEVEDtLTPPPSD | phosphorylation up-regulates activity | 27579997 | SIGNOR-279381 |
| Gbeta | SREBF1 | – | phosphorylation up-regulates activity | 10915800 | SIGNOR-270081 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | phosphorylation up-regulates → | SREBF1 PThr426 | phosphorylation down-regulates ⊣ | SREBF1 | 16825193 | SIGNOR-236649 |
| PRKACA | phosphorylation up-regulates → | SREBF1 PSer338 | phosphorylation down-regulates ⊣ | SREBF1 | 16381800 | SIGNOR-143392 |
| PRKAA2 | phosphorylation up-regulates → | SREBF1 PSer396 | phosphorylation down-regulates ⊣ | SREBF1 | 21459323 | SIGNOR-173031 |
| ERK1/2 | phosphorylation up-regulates → | SREBF1 PSer117 | phosphorylation up-regulates → | SREBF1 | 10915800 | SIGNOR-244754 |
| MAPK3 | phosphorylation up-regulates → | SREBF1 PSer117 | phosphorylation up-regulates → | SREBF1 | 10915800 | SIGNOR-80096 |
| GSK3B | phosphorylation up-regulates → | SREBF1 PSer434 | phosphorylation down-regulates ⊣ | SREBF1 | 19126544 | SIGNOR-235797 |
| MAPK1 | phosphorylation up-regulates → | SREBF1 PSer117 | phosphorylation up-regulates → | SREBF1 | 10915800 | SIGNOR-80092 |
| CDK1 | phosphorylation up-regulates → | SREBF1 PSer439 | phosphorylation up-regulates → | SREBF1 | 16880739 | SIGNOR-148354 |
| GSK3B | phosphorylation up-regulates → | SREBF1 PThr426 | phosphorylation down-regulates ⊣ | SREBF1 | 19126544 | SIGNOR-236667 |
| PLK1 | phosphorylation up-regulates → | SREBF1 PSer486 | phosphorylation up-regulates → | SREBF1 | 27579997 | SIGNOR-279383 |
| CyclinB/CDK1 | phosphorylation up-regulates → | SREBF1 PSer439 | phosphorylation up-regulates → | SREBF1 | 16880739 | SIGNOR-216821 |
| CDK8 | phosphorylation up-regulates → | SREBF1 PThr426 | phosphorylation up-regulates → | SREBF1 | 23562092 | SIGNOR-279688 |
| PLK1 | phosphorylation up-regulates → | SREBF1 PSer467 | phosphorylation up-regulates → | SREBF1 | 27579997 | SIGNOR-279382 |
| GSK3B | phosphorylation up-regulates → | SREBF1 PSer430 | phosphorylation down-regulates ⊣ | SREBF1 | 16825193 | SIGNOR-236645 |
| GSK3B | phosphorylation up-regulates → | SREBF1 PSer430 | phosphorylation down-regulates ⊣ | SREBF1 | 19126544 | SIGNOR-236030 |
| AMPK | phosphorylation up-regulates → | SREBF1 PSer396 | phosphorylation down-regulates ⊣ | SREBF1 | 21459323 | SIGNOR-216533 |
| PLK1 | phosphorylation up-regulates → | SREBF1 PThr424 | phosphorylation up-regulates → | SREBF1 | 27579997 | SIGNOR-279381 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GSK3B | phosphorylation down-regulates quantity by destabilization | SREBF1 | SIGNOR-236649 |
| PRKACA | phosphorylation down-regulates | SREBF1 | SIGNOR-143392 |
| PRKAA2 | phosphorylation down-regulates | SREBF1 | SIGNOR-173031 |
| ERK1/2 | phosphorylation → up-regulates | SREBF1 | SIGNOR-244754 |
| MAPK3 | phosphorylation → up-regulates activity | SREBF1 | SIGNOR-80096 |
| GSK3B | phosphorylation down-regulates quantity by destabilization | SREBF1 | SIGNOR-235797 |
| MAPK1 | phosphorylation → up-regulates | SREBF1 | SIGNOR-80092 |
| CDK1 | phosphorylation → up-regulates | SREBF1 | SIGNOR-148354 |
| PRKAA1 | phosphorylation → down-regulates activity | SREBF1 | SIGNOR-176497 |
| RPS6KB1 | phosphorylation → up-regulates activity | SREBF1 | SIGNOR-280120 |
| GSK3B | phosphorylation down-regulates quantity by destabilization | SREBF1 | SIGNOR-236667 |
| PLK1 | phosphorylation → up-regulates activity | SREBF1 | SIGNOR-279383 |
| CyclinB/CDK1 | phosphorylation → up-regulates | SREBF1 | SIGNOR-216821 |
| CDK8 | phosphorylation → up-regulates activity | SREBF1 | SIGNOR-279688 |
| PLK1 | phosphorylation → up-regulates activity | SREBF1 | SIGNOR-279382 |
| GSK3B | phosphorylation down-regulates quantity by destabilization | SREBF1 | SIGNOR-236645 |
| AMPK | phosphorylation down-regulates | SREBF1 | SIGNOR-216564 |
| GSK3B | phosphorylation down-regulates quantity by destabilization | SREBF1 | SIGNOR-236030 |
| AMPK | phosphorylation down-regulates | SREBF1 | SIGNOR-216533 |
| PLK1 | phosphorylation → up-regulates activity | SREBF1 | SIGNOR-279381 |
| Gbeta | phosphorylation → up-regulates activity | SREBF1 | SIGNOR-270081 |