Summary

Name SREBF1
Full Name Sterol regulatory element-binding protein 1
Synonyms SREBP-1, Class D basic helix-loop-helix protein 1, bHLHd1, Sterol regulatory element-binding transcription factor 1 | BHLHD1, SREBP1
Primary ID P36956
Links - -
Type protein
Relations 30
Pathways Insulin Receptor, MTOR Signaling
Function Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway (By similarity). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3').

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation SREBF1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SREBF1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SREBF1 0.28
Publications: 1 Organism: Homo Sapiens
Pathways:Insulin Receptor, MTOR Signaling
+ down-regulates img/direct_inhibition.png phosphorylation SREBF1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SREBF1 0.28
Publications: 2 Organism: Homo Sapiens
Pathways:MTOR Signaling
+ down-regulates img/direct_inhibition.png phosphorylation SREBF1 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation SREBF1 0.34
Publications: 5 Organism: Homo Sapiens
Pathways:Insulin Receptor, MTOR Signaling
+ up-regulates img/direct-activation.png phosphorylation SREBF1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SREBF1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation SREBF1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FASN 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation SREBF1 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Lipogenesis 0.28
Publications: 1 Organism: Mus Musculus
Pathways:Insulin Receptor, MTOR Signaling
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional repression SND1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png transcriptional regulation SREBF1 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/indirect-activation.png binding SREBF1 0.36
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation LRP1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PCSK9 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png PPARG 0.14
Publications: 1 Organism: Mus Musculus
Pathways:MTOR Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MTTP 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png VLDL assembly 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IDH1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png SREBF1 0.14
Publications: 1 Organism: Mus Musculus
Pathways:MTOR Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PKM 0.2
Publications: 2 Organism: Homo Sapiens