Entity Details

Name GSK3B_Thr426
ID P36956
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
GSK3BSREBF1Thr426TEVEDTLtPPPSDAGphosphorylation
down-regulates quantity by destabilization		16825193SIGNOR-236649
GSK3BSREBF1Thr426TEVEDTLtPPPSDAGphosphorylation
down-regulates quantity by destabilization		19126544SIGNOR-236667
CDK8SREBF1Thr426TEVEDTLtPPPSDAGphosphorylation
up-regulates activity		23562092SIGNOR-279688
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
GSK3Bphosphorylation
up-regulates
→
SREBF1
PThr426		phosphorylation
down-regulates
⊣		SREBF116825193SIGNOR-236649
GSK3Bphosphorylation
up-regulates
→
SREBF1
PThr426		phosphorylation
down-regulates
⊣		SREBF119126544SIGNOR-236667
CDK8phosphorylation
up-regulates
→
SREBF1
PThr426		phosphorylation
up-regulates
→		SREBF123562092SIGNOR-279688
Regulator Mechanism/Effect Target SIGNOR-ID
GSK3Bphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		SREBF1SIGNOR-236649
GSK3Bphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		SREBF1SIGNOR-236667
CDK8phosphorylation
→
up-regulates activity 		SREBF1SIGNOR-279688