| Name | TGFBR2 |
| ID | P37173 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 244-544 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| TGFBR2 | USP2 | Ser207 | ENYGRKGsASQVPSQ | phosphorylation up-regulates activity | 29490279 | SIGNOR-273604 |
| TGFBR2 | USP2 | Ser225 | SRVPEIIsPTYRPIG | phosphorylation up-regulates activity | 29490279 | SIGNOR-273603 |
| TGFBR2 | TGFBR1 | – | phosphorylation up-regulates | 26194464 | SIGNOR-255032 | |
| TGFBR2 | TGFBR1 | Thr200 | LPLLVQRtIARTIVL | phosphorylation up-regulates activity | 7774578 | SIGNOR-32744 |
| TGFBR2 | TGFBR1 | Thr204 | VQRTIARtIVLQESI | phosphorylation up-regulates activity | 7774578 | SIGNOR-32748 |
| TGFBR2 | TGFBR1 | Ser172 | SLDRPFIsEGTTLKD | phosphorylation up-regulates activity | 8576253 | SIGNOR-246728 |
| TGFBR2 | TGFBR1 | Thr176 | PFISEGTtLKDLIYD | phosphorylation up-regulates activity | 8576253 | SIGNOR-246732 |
| TGFBR2 | TGFBR1 | Thr176 | PFISEGTtLKDLIYD | phosphorylation up-regulates activity | 8576253 | SIGNOR-255961 |
| TGFBR2 | TGFBR1 | Thr200 | LPLLVQRtIARTIVL | phosphorylation up-regulates activity | 8576253 | SIGNOR-255962 |
| TGFBR2 | TGFBR2 | Ser416 | SVDDLANsGQVGTAR | phosphorylation down-regulates activity | 9155023 | SIGNOR-246737 |
| TGFBR2 | TGFBR2 | Ser416 | SVDDLANsGQVGTAR | phosphorylation down-regulates activity | 9155023 | SIGNOR-48412 |
| TGFBR2 | TGFBR2 | Ser213 | TRKLMEFsEHCAIIL | phosphorylation up-regulates activity | 9155023 | SIGNOR-236087 |
| TGFBR2 | TGFBR2 | Ser409 | LRLDPTLsVDDLANS | phosphorylation up-regulates activity | 9155023 | SIGNOR-246743 |
| TGFBR2 | TGFBR2 | Tyr259 | KGRFAEVyKAKLKQN | phosphorylation up-regulates activity | 9169454 | SIGNOR-48859 |
| TGFBR2 | TGFBR2 | Tyr336 | AKGNLQEyLTRHVIS | phosphorylation up-regulates activity | 9169454 | SIGNOR-48863 |
| TGFBR2 | TGFBR2 | Tyr424 | GQVGTARyMAPEVLE | phosphorylation up-regulates activity | 9169454 | SIGNOR-48867 |
| TGFBR2 | PARD6A | Ser345 | RGDGSGFsL | phosphorylation up-regulates | 15761148 | SIGNOR-227484 |
| TGFBR2 | PARD6A | Ser345 | RGDGSGFsL | phosphorylation up-regulates | 23249950 | SIGNOR-200193 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| TGFBR2 | phosphorylation up-regulates → | USP2 PSer207 | phosphorylation up-regulates → | USP2 | 29490279 | SIGNOR-273604 |
| TGFBR2 | phosphorylation up-regulates → | USP2 PSer225 | phosphorylation up-regulates → | USP2 | 29490279 | SIGNOR-273603 |
| TGFBR2 | phosphorylation up-regulates → | TGFBR1 PThr200 | phosphorylation up-regulates → | TGFBR1 | 7774578 | SIGNOR-32744 |
| TGFBR2 | phosphorylation up-regulates → | TGFBR1 PThr204 | phosphorylation up-regulates → | TGFBR1 | 7774578 | SIGNOR-32748 |
| TGFBR2 | phosphorylation up-regulates → | TGFBR1 PSer172 | phosphorylation up-regulates → | TGFBR1 | 8576253 | SIGNOR-246728 |
| TGFBR2 | phosphorylation up-regulates → | TGFBR1 PThr176 | phosphorylation up-regulates → | TGFBR1 | 8576253 | SIGNOR-246732 |
| TGFBR2 | phosphorylation up-regulates → | TGFBR1 PThr176 | phosphorylation up-regulates → | TGFBR1 | 8576253 | SIGNOR-255961 |
| TGFBR2 | phosphorylation up-regulates → | TGFBR1 PThr200 | phosphorylation up-regulates → | TGFBR1 | 8576253 | SIGNOR-255962 |
| TGFBR2 | phosphorylation up-regulates → | TGFBR2 PSer416 | phosphorylation down-regulates ⊣ | TGFBR2 | 9155023 | SIGNOR-246737 |
| TGFBR2 | phosphorylation up-regulates → | TGFBR2 PSer416 | phosphorylation down-regulates ⊣ | TGFBR2 | 9155023 | SIGNOR-48412 |
| TGFBR2 | phosphorylation up-regulates → | TGFBR2 PSer213 | phosphorylation up-regulates → | TGFBR2 | 9155023 | SIGNOR-236087 |
| TGFBR2 | phosphorylation up-regulates → | TGFBR2 PSer409 | phosphorylation up-regulates → | TGFBR2 | 9155023 | SIGNOR-246743 |
| TGFBR2 | phosphorylation up-regulates → | TGFBR2 PTyr259 | phosphorylation up-regulates → | TGFBR2 | 9169454 | SIGNOR-48859 |
| TGFBR2 | phosphorylation up-regulates → | TGFBR2 PTyr336 | phosphorylation up-regulates → | TGFBR2 | 9169454 | SIGNOR-48863 |
| TGFBR2 | phosphorylation up-regulates → | TGFBR2 PTyr424 | phosphorylation up-regulates → | TGFBR2 | 9169454 | SIGNOR-48867 |
| TGFBR2 | phosphorylation up-regulates → | PARD6A PSer345 | phosphorylation up-regulates → | PARD6A | 15761148 | SIGNOR-227484 |
| TGFBR2 | phosphorylation up-regulates → | PARD6A PSer345 | phosphorylation up-regulates → | PARD6A | 23249950 | SIGNOR-200193 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| TGFBR2 | phosphorylation → up-regulates activity | USP2 | SIGNOR-273604 |
| TGFBR2 | phosphorylation → up-regulates activity | USP2 | SIGNOR-273603 |
| TGFBR2 | phosphorylation → up-regulates | TGFBR1 | SIGNOR-255032 |
| TGFBR2 | phosphorylation → up-regulates activity | TGFBR1 | SIGNOR-32744 |
| TGFBR2 | phosphorylation → up-regulates activity | TGFBR1 | SIGNOR-32748 |
| TGFBR2 | phosphorylation → up-regulates activity | TGFBR1 | SIGNOR-246728 |
| TGFBR2 | phosphorylation → up-regulates activity | TGFBR1 | SIGNOR-246732 |
| TGFBR2 | phosphorylation → up-regulates activity | TGFBR1 | SIGNOR-255961 |
| TGFBR2 | phosphorylation → up-regulates activity | TGFBR1 | SIGNOR-255962 |
| TGFBR2 | phosphorylation → down-regulates activity | TGFBR2 | SIGNOR-246737 |
| TGFBR2 | phosphorylation → down-regulates activity | TGFBR2 | SIGNOR-48412 |
| TGFBR2 | phosphorylation → up-regulates activity | TGFBR2 | SIGNOR-236087 |
| TGFBR2 | phosphorylation → up-regulates activity | TGFBR2 | SIGNOR-246743 |
| TGFBR2 | phosphorylation → up-regulates activity | TGFBR2 | SIGNOR-48859 |
| TGFBR2 | phosphorylation → up-regulates activity | TGFBR2 | SIGNOR-48863 |
| TGFBR2 | phosphorylation → up-regulates activity | TGFBR2 | SIGNOR-48867 |
| TGFBR2 | phosphorylation → up-regulates | PARD6A | SIGNOR-227484 |
| TGFBR2 | phosphorylation → up-regulates | PARD6A | SIGNOR-200193 |