Summary

Name TGFBR2
Full Name TGF-beta receptor type-2
Synonyms TGFR-2, TGF-beta type II receptor, Transforming growth factor-beta receptor type II, TGF-beta receptor type II, TbetaR-II
Primary ID P37173
Links - -
Type protein
Relations 43
Pathways COVID-19 Causal Network, FAP: TGF beta, Fibrosis, Hepatocellular Tumor, Multiple sclerosis, Osteoblast: TGF beta, Pancreatic ductal adenocarcinoma (PDA), SARS-CoV FIBROSIS, TGF-beta Signaling, T-Lymphocyte: TGF beta, TGFb in cancer
Inhibitors LY-2157299
Function Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation TGFBR1 0.703
Publications: 6 Organism: Homo Sapiens, In Vitro, Neovison Vison
Pathways:COVID-19 Causal Network, Fibrosis, Hepatocellular Tumor, Multiple sclerosis, Pancreatic ductal adenocarcinoma (PDA), SARS-CoV FIBROSIS, Thyroid cancer, TGF-beta Signaling, TGFb in cancer
+ up-regulates activity img/direct-activation.png phosphorylation USP2 0.2
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation TGFBR2 0.2
Publications: 5 Organism: Homo Sapiens, In Vitro
Pathways:COVID-19 Causal Network, Fibrosis, Hepatocellular Tumor, Multiple sclerosis, Pancreatic ductal adenocarcinoma (PDA), SARS-CoV FIBROSIS, Thyroid cancer, TGF-beta Signaling, TGFb in cancer
+ up-regulates img/direct-activation.png phosphorylation PARD6A 0.437
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation TGFBR2 0.2
Publications: 2 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Fibrosis, Hepatocellular Tumor, Multiple sclerosis, Pancreatic ductal adenocarcinoma (PDA), SARS-CoV FIBROSIS, Thyroid cancer, TGF-beta Signaling, TGFb in cancer
+ up-regulates img/direct-activation.png phosphorylation TGFBR2 0.288
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding TGFBR2 0.845
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:COVID-19 Causal Network, Thyroid cancer, TGF-beta Signaling, TGFb in cancer
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination TGFBR2 0.574
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates img/direct-activation.png binding TGFBR2 0.503
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding TGFBR2 0.743
Publications: 2 Organism: Homo Sapiens
Pathways:TGF-beta Signaling
+ up-regulates activity img/direct-activation.png binding TGFBR2 0.2
Publications: 2 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Fibrosis, Hepatocellular Tumor, Multiple sclerosis, Pancreatic ductal adenocarcinoma (PDA), SARS-CoV FIBROSIS, Thyroid cancer, TGFb in cancer
+ up-regulates activity img/direct-activation.png binding VPS39 0.334
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png binding PIK3R1 0.46
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding TGFBR2 0.845
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Thyroid cancer, TGF-beta Signaling, TGFb in cancer
+ up-regulates img/direct-activation.png phosphorylation TGFBR1 0.703
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Fibrosis, Hepatocellular Tumor, Multiple sclerosis, Pancreatic ductal adenocarcinoma (PDA), SARS-CoV FIBROSIS, Thyroid cancer, TGF-beta Signaling, TGFb in cancer
+ up-regulates activity img/direct-activation.png binding ZFYVE9 0.547
Publications: 1 Organism: Homo Sapiens
Pathways:TGF-beta Signaling
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation TGFBR2 0.312
Publications: 1
+ up-regulates img/direct-activation.png binding PIK3R1 0.46
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding TGFBR2 0.391
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PI3K 0.423
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Hepatocellular Tumor, Pancreatic ductal adenocarcinoma (PDA)
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation TGFBR2 0.2
Publications: 1
+ up-regulates img/direct-activation.png binding PIK3R2 0.443
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png ubiquitination TGFBR2 0.574
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding TGFBR2 0.329
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png ubiquitination TGFBR2 0.594
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding TGFBR2 0.859
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png ubiquitination TGFBR2 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:TGF-beta Signaling
+ up-regulates activity img/direct-activation.png binding PI3K 0.423
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Hepatocellular Tumor, Pancreatic ductal adenocarcinoma (PDA)
+ down-regulates img/direct_inhibition.png chemical inhibition TGFBR2 0.8
Publications: 1 Organism: Homo Sapiens