| Name | TGFBR2 |
| ID | P37173 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 244-544 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| TGFBR2 | TGFBR2 | Tyr336 | AKGNLQEyLTRHVIS | phosphorylation up-regulates activity | 9169454 | SIGNOR-48863 |
| TGFBR2 | TGFBR2 | Ser409 | LRLDPTLsVDDLANS | phosphorylation up-regulates activity | 9155023 | SIGNOR-246743 |
| TGFBR2 | TGFBR2 | Tyr424 | GQVGTARyMAPEVLE | phosphorylation up-regulates activity | 9169454 | SIGNOR-48867 |
| TGFBR2 | TGFBR2 | Ser213 | TRKLMEFsEHCAIIL | phosphorylation up-regulates activity | 9155023 | SIGNOR-236087 |
| SRC | TGFBR2 | Tyr284 | KIFPYEEyASWKTEK | phosphorylation up-regulates | 19114990 | SIGNOR-182963 |
| TGFBR2 | TGFBR2 | Ser416 | SVDDLANsGQVGTAR | phosphorylation down-regulates activity | 9155023 | SIGNOR-246737 |
| TGFBR2 | TGFBR2 | Tyr259 | KGRFAEVyKAKLKQN | phosphorylation up-regulates activity | 9169454 | SIGNOR-48859 |
| TGFBR2 | TGFBR2 | Ser416 | SVDDLANsGQVGTAR | phosphorylation down-regulates activity | 9155023 | SIGNOR-48412 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| TGFBR2 | phosphorylation up-regulates → | TGFBR2 PTyr336 | phosphorylation up-regulates → | TGFBR2 | 9169454 | SIGNOR-48863 |
| TGFBR2 | phosphorylation up-regulates → | TGFBR2 PSer409 | phosphorylation up-regulates → | TGFBR2 | 9155023 | SIGNOR-246743 |
| TGFBR2 | phosphorylation up-regulates → | TGFBR2 PTyr424 | phosphorylation up-regulates → | TGFBR2 | 9169454 | SIGNOR-48867 |
| TGFBR2 | phosphorylation up-regulates → | TGFBR2 PSer213 | phosphorylation up-regulates → | TGFBR2 | 9155023 | SIGNOR-236087 |
| SRC | phosphorylation up-regulates → | TGFBR2 PTyr284 | phosphorylation up-regulates → | TGFBR2 | 19114990 | SIGNOR-182963 |
| TGFBR2 | phosphorylation up-regulates → | TGFBR2 PSer416 | phosphorylation down-regulates ⊣ | TGFBR2 | 9155023 | SIGNOR-246737 |
| TGFBR2 | phosphorylation up-regulates → | TGFBR2 PTyr259 | phosphorylation up-regulates → | TGFBR2 | 9169454 | SIGNOR-48859 |
| TGFBR2 | phosphorylation up-regulates → | TGFBR2 PSer416 | phosphorylation down-regulates ⊣ | TGFBR2 | 9155023 | SIGNOR-48412 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| TGFBR2 | phosphorylation → up-regulates activity | TGFBR2 | SIGNOR-48863 |
| TGFBR2 | phosphorylation → up-regulates activity | TGFBR2 | SIGNOR-246743 |
| TGFBR2 | phosphorylation → up-regulates activity | TGFBR2 | SIGNOR-48867 |
| TGFBR2 | phosphorylation → up-regulates activity | TGFBR2 | SIGNOR-236087 |
| SRC | phosphorylation → up-regulates | TGFBR2 | SIGNOR-182963 |
| TGFBR2 | phosphorylation → down-regulates activity | TGFBR2 | SIGNOR-246737 |
| TGFBR2 | phosphorylation → up-regulates activity | TGFBR2 | SIGNOR-48859 |
| TGFBR2 | phosphorylation → down-regulates activity | TGFBR2 | SIGNOR-48412 |