| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ERK1/2 | CDKN1A | Thr57 | NFDFVTEtPLEGDFA | phosphorylation down-regulates quantity by destabilization | 19364816 | SIGNOR-244513 |
| CDK6 | CDKN1A | Ser130 | SGEQAEGsPGGPGDS | phosphorylation down-regulates activity | 16508017 | SIGNOR-144832 |
| CHEK1 | CDKN1A | Thr145 | QGRKRRQtSMTDFYH | phosphorylation down-regulates quantity by destabilization | 25486478 | SIGNOR-279325 |
| AKT | CDKN1A | Thr145 | QGRKRRQtSMTDFYH | phosphorylation up-regulates quantity by stabilization | 16982699 | SIGNOR-244184 |
| DYRK1B | CDKN1A | Ser153 | SMTDFYHsKRRLIFS | phosphorylation up-regulates activity | 15851482 | SIGNOR-235635 |
| MAPK14 | CDKN1A | Ser130 | SGEQAEGsPGGPGDS | phosphorylation up-regulates quantity by stabilization | 12058028 | SIGNOR-89436 |
| PLCG2 | CDKN1A | Ser146 | GRKRRQTsMTDFYHS | phosphorylation up-regulates quantity by stabilization | 31575057 | SIGNOR-262963 |
| AKT1 | CDKN1A | Thr145 | QGRKRRQtSMTDFYH | phosphorylation up-regulates quantity by stabilization | 16982699 | SIGNOR-149698 |
| AKT | CDKN1A | Thr145 | QGRKRRQtSMTDFYH | phosphorylation up-regulates quantity by stabilization | 16982699 | SIGNOR-244180 |
| PRKCA | CDKN1A | Ser153 | SMTDFYHsKRRLIFS | phosphorylation up-regulates activity | 16055744 | SIGNOR-139302 |
| PIM | CDKN1A | Thr145 | QGRKRRQtSMTDFYH | phosphorylation up-regulates quantity by stabilization | 20307683 | SIGNOR-259424 |
| PIM1 | CDKN1A | Thr145 | QGRKRRQtSMTDFYH | phosphorylation up-regulates quantity by stabilization | 20307683 | SIGNOR-164642 |
| MAPK8 | CDKN1A | Ser130 | SGEQAEGsPGGPGDS | phosphorylation up-regulates quantity by stabilization | 12058028 | SIGNOR-89440 |
| MAPK1 | CDKN1A | Ser130 | SGEQAEGsPGGPGDS | phosphorylation down-regulates quantity by destabilization | 19364816 | SIGNOR-185215 |
| PIM1 | CDKN1A | Ser146 | GRKRRQTsMTDFYHS | phosphorylation up-regulates quantity by stabilization | 31575057 | SIGNOR-262961 |
| AKT1 | CDKN1A | Ser146 | GRKRRQTsMTDFYHS | phosphorylation up-regulates quantity by stabilization | 31575057 | SIGNOR-157790 |
| PLCG1 | CDKN1A | Ser146 | GRKRRQTsMTDFYHS | phosphorylation up-regulates quantity by stabilization | 31575057 | SIGNOR-262962 |
| GSK3B | CDKN1A | Ser114 | EEDHVDLsLSCTLVP | phosphorylation down-regulates quantity by destabilization | 17283049 | SIGNOR-152941 |
| DAPK3 | CDKN1A | Thr145 | QGRKRRQtSMTDFYH | phosphorylation up-regulates quantity by stabilization | 15001356 | SIGNOR-251085 |
| MAPK1 | CDKN1A | Thr57 | NFDFVTEtPLEGDFA | phosphorylation down-regulates quantity by destabilization | 19364816 | SIGNOR-185219 |
| MAPK8 | CDKN1A | Thr57 | NFDFVTEtPLEGDFA | phosphorylation up-regulates quantity by stabilization | 12058028 | SIGNOR-250118 |
| CDK2 | CDKN1A | Ser130 | SGEQAEGsPGGPGDS | phosphorylation down-regulates quantity by destabilization | 15964852 | SIGNOR-149416 |
| STK11 | CDKN1A | Thr80 | LPKLYLPtGPRRGRD | phosphorylation down-regulates activity | 25329316 | SIGNOR-278253 |
| PIM2 | CDKN1A | Thr145 | QGRKRRQtSMTDFYH | phosphorylation up-regulates quantity by stabilization | 20307683 | SIGNOR-164646 |
| MAP3K5 | CDKN1A | Ser98 | GGRRPGTsPALLQGT | phosphorylation up-regulates | 17325029 | SIGNOR-153440 |
| CHEK1 | CDKN1A | Ser146 | GRKRRQTsMTDFYHS | phosphorylation down-regulates quantity by destabilization | 25486478 | SIGNOR-279324 |
| ERK1/2 | CDKN1A | Ser130 | SGEQAEGsPGGPGDS | phosphorylation down-regulates quantity by destabilization | 19364816 | SIGNOR-244618 |
| LATS2 | CDKN1A | Ser146 | GRKRRQTsMTDFYHS | phosphorylation down-regulates quantity | 23886938 | SIGNOR-279530 |
| STK38 | CDKN1A | Ser146 | GRKRRQTsMTDFYHS | phosphorylation down-regulates quantity by destabilization | 21262772 | SIGNOR-272961 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ERK1/2 | phosphorylation up-regulates → | CDKN1A PThr57 | phosphorylation down-regulates ⊣ | CDKN1A | 19364816 | SIGNOR-244513 |
| CDK6 | phosphorylation up-regulates → | CDKN1A PSer130 | phosphorylation down-regulates ⊣ | CDKN1A | 16508017 | SIGNOR-144832 |
| CHEK1 | phosphorylation up-regulates → | CDKN1A PThr145 | phosphorylation down-regulates ⊣ | CDKN1A | 25486478 | SIGNOR-279325 |
| AKT | phosphorylation up-regulates → | CDKN1A PThr145 | phosphorylation up-regulates → | CDKN1A | 16982699 | SIGNOR-244184 |
| DYRK1B | phosphorylation up-regulates → | CDKN1A PSer153 | phosphorylation up-regulates → | CDKN1A | 15851482 | SIGNOR-235635 |
| MAPK14 | phosphorylation up-regulates → | CDKN1A PSer130 | phosphorylation up-regulates → | CDKN1A | 12058028 | SIGNOR-89436 |
| PLCG2 | phosphorylation up-regulates → | CDKN1A PSer146 | phosphorylation up-regulates → | CDKN1A | 31575057 | SIGNOR-262963 |
| AKT1 | phosphorylation up-regulates → | CDKN1A PThr145 | phosphorylation up-regulates → | CDKN1A | 16982699 | SIGNOR-149698 |
| AKT | phosphorylation up-regulates → | CDKN1A PThr145 | phosphorylation up-regulates → | CDKN1A | 16982699 | SIGNOR-244180 |
| PRKCA | phosphorylation up-regulates → | CDKN1A PSer153 | phosphorylation up-regulates → | CDKN1A | 16055744 | SIGNOR-139302 |
| PIM | phosphorylation up-regulates → | CDKN1A PThr145 | phosphorylation up-regulates → | CDKN1A | 20307683 | SIGNOR-259424 |
| PIM1 | phosphorylation up-regulates → | CDKN1A PThr145 | phosphorylation up-regulates → | CDKN1A | 20307683 | SIGNOR-164642 |
| MAPK8 | phosphorylation up-regulates → | CDKN1A PSer130 | phosphorylation up-regulates → | CDKN1A | 12058028 | SIGNOR-89440 |
| MAPK1 | phosphorylation up-regulates → | CDKN1A PSer130 | phosphorylation down-regulates ⊣ | CDKN1A | 19364816 | SIGNOR-185215 |
| PIM1 | phosphorylation up-regulates → | CDKN1A PSer146 | phosphorylation up-regulates → | CDKN1A | 31575057 | SIGNOR-262961 |
| AKT1 | phosphorylation up-regulates → | CDKN1A PSer146 | phosphorylation up-regulates → | CDKN1A | 31575057 | SIGNOR-157790 |
| PLCG1 | phosphorylation up-regulates → | CDKN1A PSer146 | phosphorylation up-regulates → | CDKN1A | 31575057 | SIGNOR-262962 |
| GSK3B | phosphorylation up-regulates → | CDKN1A PSer114 | phosphorylation down-regulates ⊣ | CDKN1A | 17283049 | SIGNOR-152941 |
| DAPK3 | phosphorylation up-regulates → | CDKN1A PThr145 | phosphorylation up-regulates → | CDKN1A | 15001356 | SIGNOR-251085 |
| MAPK1 | phosphorylation up-regulates → | CDKN1A PThr57 | phosphorylation down-regulates ⊣ | CDKN1A | 19364816 | SIGNOR-185219 |
| MAPK8 | phosphorylation up-regulates → | CDKN1A PThr57 | phosphorylation up-regulates → | CDKN1A | 12058028 | SIGNOR-250118 |
| CDK2 | phosphorylation up-regulates → | CDKN1A PSer130 | phosphorylation down-regulates ⊣ | CDKN1A | 15964852 | SIGNOR-149416 |
| STK11 | phosphorylation up-regulates → | CDKN1A PThr80 | phosphorylation down-regulates ⊣ | CDKN1A | 25329316 | SIGNOR-278253 |
| PIM2 | phosphorylation up-regulates → | CDKN1A PThr145 | phosphorylation up-regulates → | CDKN1A | 20307683 | SIGNOR-164646 |
| MAP3K5 | phosphorylation up-regulates → | CDKN1A PSer98 | phosphorylation up-regulates → | CDKN1A | 17325029 | SIGNOR-153440 |
| CHEK1 | phosphorylation up-regulates → | CDKN1A PSer146 | phosphorylation down-regulates ⊣ | CDKN1A | 25486478 | SIGNOR-279324 |
| ERK1/2 | phosphorylation up-regulates → | CDKN1A PSer130 | phosphorylation down-regulates ⊣ | CDKN1A | 19364816 | SIGNOR-244618 |
| LATS2 | phosphorylation up-regulates → | CDKN1A PSer146 | phosphorylation down-regulates ⊣ | CDKN1A | 23886938 | SIGNOR-279530 |
| STK38 | phosphorylation up-regulates → | CDKN1A PSer146 | phosphorylation down-regulates ⊣ | CDKN1A | 21262772 | SIGNOR-272961 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ERK1/2 | phosphorylation down-regulates quantity by destabilization | CDKN1A | SIGNOR-244513 |
| CDK6 | phosphorylation → down-regulates activity | CDKN1A | SIGNOR-144832 |
| CHEK1 | phosphorylation down-regulates quantity by destabilization | CDKN1A | SIGNOR-279325 |
| AKT | phosphorylation → up-regulates quantity by stabilization | CDKN1A | SIGNOR-244184 |
| DYRK1B | phosphorylation → up-regulates activity | CDKN1A | SIGNOR-235635 |
| MAPK14 | phosphorylation → up-regulates quantity by stabilization | CDKN1A | SIGNOR-89436 |
| PLCG2 | phosphorylation → up-regulates quantity by stabilization | CDKN1A | SIGNOR-262963 |
| AKT1 | phosphorylation → up-regulates quantity by stabilization | CDKN1A | SIGNOR-149698 |
| AKT | phosphorylation → up-regulates quantity by stabilization | CDKN1A | SIGNOR-244180 |
| PRKCA | phosphorylation → up-regulates activity | CDKN1A | SIGNOR-139302 |
| PIM | phosphorylation → up-regulates quantity by stabilization | CDKN1A | SIGNOR-259424 |
| PIM1 | phosphorylation → up-regulates quantity by stabilization | CDKN1A | SIGNOR-164642 |
| MAPK8 | phosphorylation → up-regulates quantity by stabilization | CDKN1A | SIGNOR-89440 |
| MAPK1 | phosphorylation down-regulates quantity by destabilization | CDKN1A | SIGNOR-185215 |
| PIM1 | phosphorylation → up-regulates quantity by stabilization | CDKN1A | SIGNOR-262961 |
| AKT1 | phosphorylation → up-regulates quantity by stabilization | CDKN1A | SIGNOR-157790 |
| PLCG1 | phosphorylation → up-regulates quantity by stabilization | CDKN1A | SIGNOR-262962 |
| GSK3B | phosphorylation down-regulates quantity by destabilization | CDKN1A | SIGNOR-152941 |
| DAPK3 | phosphorylation → up-regulates quantity by stabilization | CDKN1A | SIGNOR-251085 |
| MAPK1 | phosphorylation down-regulates quantity by destabilization | CDKN1A | SIGNOR-185219 |
| MAPK8 | phosphorylation → up-regulates quantity by stabilization | CDKN1A | SIGNOR-250118 |
| CDK2 | phosphorylation down-regulates quantity by destabilization | CDKN1A | SIGNOR-149416 |
| STK11 | phosphorylation → down-regulates activity | CDKN1A | SIGNOR-278253 |
| PIM2 | phosphorylation → up-regulates quantity by stabilization | CDKN1A | SIGNOR-164646 |
| MAP3K5 | phosphorylation → up-regulates | CDKN1A | SIGNOR-153440 |
| CHEK1 | phosphorylation down-regulates quantity by destabilization | CDKN1A | SIGNOR-279324 |
| ERK1/2 | phosphorylation down-regulates quantity by destabilization | CDKN1A | SIGNOR-244618 |
| LATS2 | phosphorylation → down-regulates quantity | CDKN1A | SIGNOR-279530 |
| STK38 | phosphorylation down-regulates quantity by destabilization | CDKN1A | SIGNOR-272961 |
