Summary

Name CDKN1A
Full Name Cyclin-dependent kinase inhibitor 1
Synonyms CDK-interacting protein 1, Melanoma differentiation-associated protein 6, MDA-6, p21 | CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1
Primary ID P38936
Links - -
Type protein
Relations 89
Pathways Acute Myeloid Leukemia, FLT3-ITD in AML, FLT3-ITD signaling, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, p53 in cancer, Rhabdomyosarcoma
Function May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (PubMed:11595739). Plays an important role in controlling cell cycle progression and DNA damage-induced G2 arrest (PubMed:9106657).

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation CDKN1A 0.415
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD signaling, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation CDKN1A 0.377
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation CDKN1A 0.2
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML, FLT3-ITD signaling, Rhabdomyosarcoma
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation CDKN1A 0.953
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CDKN1A 0.857
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation CDKN1A 0.657
Publications: 2 Organism: Homo Sapiens, In Vitro
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation CDKN1A 0.46
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation CDKN1A 0.267
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation CDKN1A 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation CDKN1A 0.834
Publications: 2 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation CDKN1A 0.497
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML, FLT3-ITD signaling
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation CDKN1A 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CDKN1A 0.262
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation CDKN1A 0.39
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CDKN1A 0.573
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation CDKN1A 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation CDKN1A 0.2
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML, FLT3-ITD signaling, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, Rhabdomyosarcoma
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation CDKN1A 0.417
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation CDKN1A 0.32
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png binding CyclinE/CDK2 0.886
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, p53 in cancer
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CDKN1A 0.318
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination CDKN1A 0.318
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding CDKN1A 0.668
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination CDKN1A 0.336
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CDKN1A 0.873
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML, FLT3-ITD signaling, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, p53 in cancer
+ down-regulates img/direct_inhibition.png ubiquitination CDKN1A 0.761
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png post transcriptional regulation CDKN1A 0.328
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CDKN1A 0.382
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CDKN1A 0.873
Publications: 3 Organism: Homo Sapiens
Tissue: Brain
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML, FLT3-ITD signaling, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, p53 in cancer
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation CDKN1A 0.357
Publications: 1 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma
+ down-regulates img/direct_inhibition.png binding CDK4 0.938
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CDKN1A 0.295
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML, FLT3-ITD signaling
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CDKN1A 0.418
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CDKN1A 0.323
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding CyclinB/CDK1 0.849
Publications: 1
Pathways:Cell cycle: G2/M phase transition
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CDKN1A 0.333
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML, FLT3-ITD signaling
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination CDKN1A 0.665
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CDKN1A 0.368
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png binding CDKN1A 0.669
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD signaling, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, p53 in cancer
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CDKN1A 0.417
Publications: 1 Organism: Mus Musculus
Pathways:Rhabdomyosarcoma
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CDKN1A 0.494
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation CDKN1A 0.773
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML, FLT3-ITD signaling, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, Rhabdomyosarcoma
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CDKN1A 0.349
Publications: 1 Organism: Mus Musculus
+ down-regulates img/indirect_inhibition.png Cell_cycle_progress 0.7
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation CDKN1A 0.312
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding CDK3 0.661
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png post transcriptional regulation CDKN1A 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png CDKN1A 0.669
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD signaling, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, p53 in cancer
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CDKN1A 0.316
Publications: 1 Organism: Mus Musculus
+ up-regulates img/indirect-activation.png Cell_cycle_exit 0.7
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CDKN1A 0.316
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CDKN1A 0.344
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CDKN1A 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CDKN1A 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CDKN1A 0.315
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Cell_cycle_block 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, p53 in cancer
+ down-regulates img/direct_inhibition.png binding CDK6 0.857
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ down-regulates img/direct_inhibition.png binding CCNB1 0.822
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation CDKN1A 0.342
Publications: 1 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma
+ up-regulates img/indirect-activation.png CDKN1A 0.417
Publications: 1 Organism: Mus Musculus
Pathways:Rhabdomyosarcoma
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CDKN1A 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle, Myotube
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation CDKN1A 0.252
Publications: 1 Organism: Rattus Norvegicus
Tissue: Sciatic Nerve
+ down-regulates activity img/direct_inhibition.png binding CDKN1A 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML, FLT3-ITD signaling, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, Rhabdomyosarcoma
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CDKN1A 0.275
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CDKN1A 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png transcriptional regulation CDKN1A 0.417
Publications: 1 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma
+ up-regulates activity img/indirect-activation.png RB1 0.703
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, p53 in cancer, Rhabdomyosarcoma
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CDKN1A 0.267
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png CDKN1A 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Myotube
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination CDKN1A 0.366
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CDKN1A 0.773
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML, FLT3-ITD signaling, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, Rhabdomyosarcoma
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CDKN1A 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CDKN1A 0.255
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CDKN1A 0.298
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding CDK1 0.876
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CDKN1A 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding PCNA 0.749
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding CDK2 0.953
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CDKN1A 0.387
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CDKN1A 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates quantity by destabilization img/direct_inhibition.png post transcriptional regulation CDKN1A 0.257
Publications: 1 Organism: Mus Musculus