| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PIM1 | CDKN1A | Ser146 | GRKRRQTsMTDFYHS | phosphorylation up-regulates quantity by stabilization | 31575057 | SIGNOR-262961 |
| AKT1 | CDKN1A | Ser146 | GRKRRQTsMTDFYHS | phosphorylation up-regulates quantity by stabilization | 31575057 | SIGNOR-157790 |
| PLCG1 | CDKN1A | Ser146 | GRKRRQTsMTDFYHS | phosphorylation up-regulates quantity by stabilization | 31575057 | SIGNOR-262962 |
| CHEK1 | CDKN1A | Ser146 | GRKRRQTsMTDFYHS | phosphorylation down-regulates quantity by destabilization | 25486478 | SIGNOR-279324 |
| LATS2 | CDKN1A | Ser146 | GRKRRQTsMTDFYHS | phosphorylation down-regulates quantity | 23886938 | SIGNOR-279530 |
| STK38 | CDKN1A | Ser146 | GRKRRQTsMTDFYHS | phosphorylation down-regulates quantity by destabilization | 21262772 | SIGNOR-272961 |
| PLCG2 | CDKN1A | Ser146 | GRKRRQTsMTDFYHS | phosphorylation up-regulates quantity by stabilization | 31575057 | SIGNOR-262963 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PIM1 | phosphorylation up-regulates → | CDKN1A PSer146 | phosphorylation up-regulates → | CDKN1A | 31575057 | SIGNOR-262961 |
| AKT1 | phosphorylation up-regulates → | CDKN1A PSer146 | phosphorylation up-regulates → | CDKN1A | 31575057 | SIGNOR-157790 |
| PLCG1 | phosphorylation up-regulates → | CDKN1A PSer146 | phosphorylation up-regulates → | CDKN1A | 31575057 | SIGNOR-262962 |
| CHEK1 | phosphorylation up-regulates → | CDKN1A PSer146 | phosphorylation down-regulates ⊣ | CDKN1A | 25486478 | SIGNOR-279324 |
| LATS2 | phosphorylation up-regulates → | CDKN1A PSer146 | phosphorylation down-regulates ⊣ | CDKN1A | 23886938 | SIGNOR-279530 |
| STK38 | phosphorylation up-regulates → | CDKN1A PSer146 | phosphorylation down-regulates ⊣ | CDKN1A | 21262772 | SIGNOR-272961 |
| PLCG2 | phosphorylation up-regulates → | CDKN1A PSer146 | phosphorylation up-regulates → | CDKN1A | 31575057 | SIGNOR-262963 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PIM1 | phosphorylation → up-regulates quantity by stabilization | CDKN1A | SIGNOR-262961 |
| AKT1 | phosphorylation → up-regulates quantity by stabilization | CDKN1A | SIGNOR-157790 |
| PLCG1 | phosphorylation → up-regulates quantity by stabilization | CDKN1A | SIGNOR-262962 |
| CHEK1 | phosphorylation down-regulates quantity by destabilization | CDKN1A | SIGNOR-279324 |
| LATS2 | phosphorylation → down-regulates quantity | CDKN1A | SIGNOR-279530 |
| STK38 | phosphorylation down-regulates quantity by destabilization | CDKN1A | SIGNOR-272961 |
| PLCG2 | phosphorylation → up-regulates quantity by stabilization | CDKN1A | SIGNOR-262963 |
