| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PIM2 | CDKN1A | Thr145 | QGRKRRQtSMTDFYH | phosphorylation up-regulates quantity by stabilization | 20307683 | SIGNOR-164646 |
| CHEK1 | CDKN1A | Thr145 | QGRKRRQtSMTDFYH | phosphorylation down-regulates quantity by destabilization | 25486478 | SIGNOR-279325 |
| AKT | CDKN1A | Thr145 | QGRKRRQtSMTDFYH | phosphorylation up-regulates quantity by stabilization | 16982699 | SIGNOR-244184 |
| AKT1 | CDKN1A | Thr145 | QGRKRRQtSMTDFYH | phosphorylation up-regulates quantity by stabilization | 16982699 | SIGNOR-149698 |
| AKT | CDKN1A | Thr145 | QGRKRRQtSMTDFYH | phosphorylation up-regulates quantity by stabilization | 16982699 | SIGNOR-244180 |
| PIM | CDKN1A | Thr145 | QGRKRRQtSMTDFYH | phosphorylation up-regulates quantity by stabilization | 20307683 | SIGNOR-259424 |
| PIM1 | CDKN1A | Thr145 | QGRKRRQtSMTDFYH | phosphorylation up-regulates quantity by stabilization | 20307683 | SIGNOR-164642 |
| DAPK3 | CDKN1A | Thr145 | QGRKRRQtSMTDFYH | phosphorylation up-regulates quantity by stabilization | 15001356 | SIGNOR-251085 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PIM2 | phosphorylation up-regulates → | CDKN1A PThr145 | phosphorylation up-regulates → | CDKN1A | 20307683 | SIGNOR-164646 |
| CHEK1 | phosphorylation up-regulates → | CDKN1A PThr145 | phosphorylation down-regulates ⊣ | CDKN1A | 25486478 | SIGNOR-279325 |
| AKT | phosphorylation up-regulates → | CDKN1A PThr145 | phosphorylation up-regulates → | CDKN1A | 16982699 | SIGNOR-244184 |
| AKT1 | phosphorylation up-regulates → | CDKN1A PThr145 | phosphorylation up-regulates → | CDKN1A | 16982699 | SIGNOR-149698 |
| AKT | phosphorylation up-regulates → | CDKN1A PThr145 | phosphorylation up-regulates → | CDKN1A | 16982699 | SIGNOR-244180 |
| PIM | phosphorylation up-regulates → | CDKN1A PThr145 | phosphorylation up-regulates → | CDKN1A | 20307683 | SIGNOR-259424 |
| PIM1 | phosphorylation up-regulates → | CDKN1A PThr145 | phosphorylation up-regulates → | CDKN1A | 20307683 | SIGNOR-164642 |
| DAPK3 | phosphorylation up-regulates → | CDKN1A PThr145 | phosphorylation up-regulates → | CDKN1A | 15001356 | SIGNOR-251085 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PIM2 | phosphorylation → up-regulates quantity by stabilization | CDKN1A | SIGNOR-164646 |
| CHEK1 | phosphorylation down-regulates quantity by destabilization | CDKN1A | SIGNOR-279325 |
| AKT | phosphorylation → up-regulates quantity by stabilization | CDKN1A | SIGNOR-244184 |
| AKT1 | phosphorylation → up-regulates quantity by stabilization | CDKN1A | SIGNOR-149698 |
| AKT | phosphorylation → up-regulates quantity by stabilization | CDKN1A | SIGNOR-244180 |
| PIM | phosphorylation → up-regulates quantity by stabilization | CDKN1A | SIGNOR-259424 |
| PIM1 | phosphorylation → up-regulates quantity by stabilization | CDKN1A | SIGNOR-164642 |
| DAPK3 | phosphorylation → up-regulates quantity by stabilization | CDKN1A | SIGNOR-251085 |
