| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK8 | CDKN1A | Ser130 | SGEQAEGsPGGPGDS | phosphorylation up-regulates quantity by stabilization | 12058028 | SIGNOR-89440 |
| MAPK1 | CDKN1A | Ser130 | SGEQAEGsPGGPGDS | phosphorylation down-regulates quantity by destabilization | 19364816 | SIGNOR-185215 |
| CDK2 | CDKN1A | Ser130 | SGEQAEGsPGGPGDS | phosphorylation down-regulates quantity by destabilization | 15964852 | SIGNOR-149416 |
| ERK1/2 | CDKN1A | Ser130 | SGEQAEGsPGGPGDS | phosphorylation down-regulates quantity by destabilization | 19364816 | SIGNOR-244618 |
| CDK6 | CDKN1A | Ser130 | SGEQAEGsPGGPGDS | phosphorylation down-regulates activity | 16508017 | SIGNOR-144832 |
| MAPK14 | CDKN1A | Ser130 | SGEQAEGsPGGPGDS | phosphorylation up-regulates quantity by stabilization | 12058028 | SIGNOR-89436 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK8 | phosphorylation up-regulates → | CDKN1A PSer130 | phosphorylation up-regulates → | CDKN1A | 12058028 | SIGNOR-89440 |
| MAPK1 | phosphorylation up-regulates → | CDKN1A PSer130 | phosphorylation down-regulates ⊣ | CDKN1A | 19364816 | SIGNOR-185215 |
| CDK2 | phosphorylation up-regulates → | CDKN1A PSer130 | phosphorylation down-regulates ⊣ | CDKN1A | 15964852 | SIGNOR-149416 |
| ERK1/2 | phosphorylation up-regulates → | CDKN1A PSer130 | phosphorylation down-regulates ⊣ | CDKN1A | 19364816 | SIGNOR-244618 |
| CDK6 | phosphorylation up-regulates → | CDKN1A PSer130 | phosphorylation down-regulates ⊣ | CDKN1A | 16508017 | SIGNOR-144832 |
| MAPK14 | phosphorylation up-regulates → | CDKN1A PSer130 | phosphorylation up-regulates → | CDKN1A | 12058028 | SIGNOR-89436 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK8 | phosphorylation → up-regulates quantity by stabilization | CDKN1A | SIGNOR-89440 |
| MAPK1 | phosphorylation down-regulates quantity by destabilization | CDKN1A | SIGNOR-185215 |
| CDK2 | phosphorylation down-regulates quantity by destabilization | CDKN1A | SIGNOR-149416 |
| ERK1/2 | phosphorylation down-regulates quantity by destabilization | CDKN1A | SIGNOR-244618 |
| CDK6 | phosphorylation → down-regulates activity | CDKN1A | SIGNOR-144832 |
| MAPK14 | phosphorylation → up-regulates quantity by stabilization | CDKN1A | SIGNOR-89436 |
