Entity Details

Name IL6ST
ID P40189
Role kinase
Enzymatic Domains
Ig-like C2-type 26-120
Fibronectin type-III 1 125-216
PROSITE-ProRule
Fibronectin type-III 2 224-324
PROSITE-ProRule
Fibronectin type-III 3 329-424
PROSITE-ProRule
Fibronectin type-III 4 426-517
PROSITE-ProRule
Fibronectin type-III 5 518-613
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
IL6STJAK2Tyr1007VLPQDKEyYKVKEPGphosphorylation
up-regulates activity		9716487SIGNOR-238630
IL6STJAK2Tyr1008LPQDKEYyKVKEPGEphosphorylation
up-regulates activity		9716487SIGNOR-238634
IL6STYES1–phosphorylation
up-regulates activity		31296870SIGNOR-278033
IL6STIL6STSer659WPNVPDPsKSHIAQWphosphorylation
up-regulates activity		8511589SIGNOR-238621
IL6STIL6STSer661NVPDPSKsHIAQWSPphosphorylation
up-regulates activity		8511589SIGNOR-238625
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
IL6STphosphorylation
up-regulates
→
JAK2
PTyr1007		phosphorylation
up-regulates
→		JAK29716487SIGNOR-238630
IL6STphosphorylation
up-regulates
→
JAK2
PTyr1008		phosphorylation
up-regulates
→		JAK29716487SIGNOR-238634
IL6STphosphorylation
up-regulates
→
IL6ST
PSer659		phosphorylation
up-regulates
→		IL6ST8511589SIGNOR-238621
IL6STphosphorylation
up-regulates
→
IL6ST
PSer661		phosphorylation
up-regulates
→		IL6ST8511589SIGNOR-238625
Regulator Mechanism/Effect Target SIGNOR-ID
IL6STphosphorylation
→
up-regulates activity 		JAK2SIGNOR-238630
IL6STphosphorylation
→
up-regulates activity 		JAK2SIGNOR-238634
IL6STphosphorylation
→
up-regulates activity 		YES1SIGNOR-278033
IL6STphosphorylation
→
up-regulates activity 		IL6STSIGNOR-238621
IL6STphosphorylation
→
up-regulates activity 		IL6STSIGNOR-238625