Summary

Name IL6ST
Full Name Interleukin-6 receptor subunit beta
Synonyms IL-6 receptor subunit beta, IL-6R subunit beta, IL-6R-beta, IL-6RB, CDw130, Interleukin-6 signal transducer, Membrane glycoprotein 130, gp130, Oncostatin-M receptor subunit alpha
Primary ID P40189
Links - -
Type protein
Relations 23
Pathways IL6
Function Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases (PubMed:2261637). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:19915009, PubMed:23294003). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity). Has a role in embryonic development (By similarity). Does not bind IL6 (PubMed:2261637). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity). Required for expression of TRPA1 in nociceptive neurons (By similarity). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity). Required for normal trabecular bone mass and cortical bone composition (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation IL6ST 0.46
Publications: 2 Organism: In Vitro
Pathways:IL6
+ up-regulates img/direct-activation.png phosphorylation IL6ST 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation IL6ST 0.14
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation JAK2 0.38
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding IL6ST 0.34
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ up-regulates img/direct-activation.png binding IL6ST 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding IL6ST 0.31
Publications: 1 Organism: Homo Sapiens
Pathways:IL6
+ up-regulates img/direct-activation.png binding IL6ST 0.5
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
Pathways:IL6
+ up-regulates img/direct-activation.png binding IL6ST 0.42
Publications: 1 Organism: Homo Sapiens
Pathways:IL6
+ up-regulates img/direct-activation.png binding IL6ST 0.45
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding, JAK1 0.61
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
Pathways:IL6
+ up-regulates img/direct-activation.png binding IL6ST 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding IL6ST 0.28
Publications: 1 Organism: Homo Sapiens
Pathways:IL6
+ up-regulates img/indirect-activation.png phosphorylation ERK1/2 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:IL6
+ up-regulates img/direct-activation.png binding SHC1 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:IL6
+ up-regulates activity img/indirect-activation.png IL6ST 0.28
Publications: 1 Organism: In Vitro
Pathways:IL6
+ up-regulates img/direct-activation.png binding IL6ST 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding IL6ST 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:IL6