Entity Details

Name IL6ST
ID P40189
Role substrate
Enzymatic Domains
Ig-like C2-type 26-120
Fibronectin type-III 1 125-216
PROSITE-ProRule
Fibronectin type-III 2 224-324
PROSITE-ProRule
Fibronectin type-III 3 329-424
PROSITE-ProRule
Fibronectin type-III 4 426-517
PROSITE-ProRule
Fibronectin type-III 5 518-613
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PRKCDIL6STThr909PKSYLPQtVRQGGYMphosphorylation
up-regulates activity		12361954SIGNOR-249177
PRKCDIL6STThr890GQVERFEtVGMEAATphosphorylation
up-regulates		12361954SIGNOR-94012
IL6STIL6STSer659WPNVPDPsKSHIAQWphosphorylation
up-regulates activity		8511589SIGNOR-238621
IL6STIL6STSer661NVPDPSKsHIAQWSPphosphorylation
up-regulates activity		8511589SIGNOR-238625
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PRKCDphosphorylation
up-regulates
→
IL6ST
PThr909		phosphorylation
up-regulates
→		IL6ST12361954SIGNOR-249177
PRKCDphosphorylation
up-regulates
→
IL6ST
PThr890		phosphorylation
up-regulates
→		IL6ST12361954SIGNOR-94012
IL6STphosphorylation
up-regulates
→
IL6ST
PSer659		phosphorylation
up-regulates
→		IL6ST8511589SIGNOR-238621
IL6STphosphorylation
up-regulates
→
IL6ST
PSer661		phosphorylation
up-regulates
→		IL6ST8511589SIGNOR-238625
Regulator Mechanism/Effect Target SIGNOR-ID
PRKCDphosphorylation
→
up-regulates activity 		IL6STSIGNOR-249177
PRKCDphosphorylation
→
up-regulates 		IL6STSIGNOR-94012
IL6STphosphorylation
→
up-regulates activity 		IL6STSIGNOR-238621
IL6STphosphorylation
→
up-regulates activity 		IL6STSIGNOR-238625