| Name | STAT3 |
| ID | P40763 |
| Role | substrate |
| Enzymatic Domains |
SH2 580-670 PROSITE-ProRule |
View in  |
|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP3K1 | STAT3 | Ser727 | NTIDLPMsPRTLDSL | phosphorylation up-regulates activity | 17563747 | SIGNOR-236346 |
| MAPK1 | STAT3 | – | phosphorylation down-regulates activity | 9872331 | SIGNOR-279635 | |
| EIF2AK2 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | phosphorylation up-regulates activity | 25360179 | SIGNOR-279613 |
| FGFR3 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | phosphorylation up-regulates activity | 10918587 | SIGNOR-251139 |
| MAPK3 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | phosphorylation up-regulates | 14551213 | SIGNOR-118600 |
| MET | STAT3 | – | phosphorylation up-regulates activity | 30143645 | SIGNOR-280041 | |
| NEK6 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | phosphorylation up-regulates activity | 20595392 | SIGNOR-273901 |
| PKM | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | phosphorylation up-regulates | 22306293 | SIGNOR-195766 |
| NEK6 | STAT3 | Ser727 | NTIDLPMsPRTLDSL | phosphorylation up-regulates activity | 20595392 | SIGNOR-273902 |
| LCK | STAT3 | – | phosphorylation up-regulates activity | 10617281 | SIGNOR-279201 | |
| PTPRR | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | dephosphorylation down-regulates activity | 17360477 | SIGNOR-248719 |
| PTPN6 | STAT3 | – | dephosphorylation down-regulates | 18508557 | SIGNOR-178699 | |
| MAP3K14 | STAT3 | Ser727 | NTIDLPMsPRTLDSL | phosphorylation up-regulates activity | 17543278 | SIGNOR-279340 |
| PTPRT | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | dephosphorylation down-regulates activity | 17360477 | SIGNOR-263981 |
| PTPN4 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | dephosphorylation down-regulates activity | 31025789 | SIGNOR-277057 |
| EGFR | STAT3 | – | phosphorylation up-regulates activity | 14967450 | SIGNOR-121965 | |
| LYN | STAT3 | – | phosphorylation up-regulates activity | 17146444 | SIGNOR-279062 | |
| PK | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | phosphorylation up-regulates | 22306293 | SIGNOR-268152 |
| EPHB1 | STAT3 | – | phosphorylation up-regulates activity | 29079839 | SIGNOR-279709 | |
| ABL1 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | phosphorylation up-regulates activity | 23383209 | SIGNOR-279675 |
| PTPRG | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | dephosphorylation up-regulates activity | 25624455 | SIGNOR-254729 |
| BTK | STAT3 | – | phosphorylation down-regulates activity | 9751072 | SIGNOR-279011 | |
| MAP3K14 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | phosphorylation up-regulates activity | 17543278 | SIGNOR-279341 |
| PTPN9 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | dephosphorylation down-regulates activity | 22394684 | SIGNOR-276976 |
| ALK | STAT3 | – | phosphorylation up-regulates activity | 11850821 | SIGNOR-279319 | |
| PTPN1 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | dephosphorylation down-regulates | 15821101 | SIGNOR-135211 |
| FER | STAT3 | – | phosphorylation up-regulates activity | 10878010 | SIGNOR-279713 | |
| RPS6KA5 | STAT3 | – | phosphorylation up-regulates | 20626350 | SIGNOR-166664 | |
| PTPN11 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | dephosphorylation down-regulates activity | 16611743 | SIGNOR-272404 |
| RET/PTC2 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | phosphorylation up-regulates activity | 12637586 | SIGNOR-260917 |
| MAPK3 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | phosphorylation up-regulates | 19723038 | SIGNOR-187787 |
| PK | STAT3 | – | phosphorylation up-regulates activity | 22306293 | SIGNOR-270312 | |
| JAK1 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | phosphorylation up-regulates activity | 19723038 | SIGNOR-187775 |
| PTPRT | STAT3 | – | dephosphorylation down-regulates activity | 17360477 | SIGNOR-277043 | |
| CDK5 | STAT3 | Ser727 | NTIDLPMsPRTLDSL | phosphorylation up-regulates | 15096606 | SIGNOR-124325 |
| PRKCE | STAT3 | Ser727 | NTIDLPMsPRTLDSL | phosphorylation up-regulates | 16418226 | SIGNOR-143832 |
| JAK3 | STAT3 | – | phosphorylation up-regulates | 30029643 | SIGNOR-256254 | |
| MAPK3 | STAT3 | Ser727 | NTIDLPMsPRTLDSL | phosphorylation up-regulates activity | 14551213 | SIGNOR-249450 |
| PTK2B | STAT3 | – | phosphorylation up-regulates activity | 26084289 | SIGNOR-279429 | |
| DAPK3 | STAT3 | Ser727 | NTIDLPMsPRTLDSL | phosphorylation up-regulates activity | 16219639 | SIGNOR-279702 |
| PTPRK | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | dephosphorylation down-regulates activity | 25612622 | SIGNOR-277060 |
| PTPRD | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | dephosphorylation down-regulates activity | 19478061 | SIGNOR-248442 |
| PRKCD | STAT3 | Ser727 | NTIDLPMsPRTLDSL | phosphorylation up-regulates | 16418226 | SIGNOR-143828 |
| PTPRO | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | dephosphorylation down-regulates activity | 24708807 | SIGNOR-277062 |
| JAK1 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | phosphorylation up-regulates activity | 26260587 | SIGNOR-249546 |
| PTPN2 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | dephosphorylation down-regulates | 12138178 | SIGNOR-90818 |
| NLK | STAT3 | Ser727 | NTIDLPMsPRTLDSL | phosphorylation up-regulates | 17563747 | SIGNOR-155828 |
| PTPRM | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | dephosphorylation down-regulates activity | 31900385 | SIGNOR-277016 |
| SRC | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | phosphorylation up-regulates activity | 14551213 | SIGNOR-247341 |
| MAPK14 | STAT3 | Ser727 | NTIDLPMsPRTLDSL | phosphorylation up-regulates | 17502367 | SIGNOR-154783 |
| MAPK9 | STAT3 | Ser727 | NTIDLPMsPRTLDSL | phosphorylation up-regulates | 18691976 | SIGNOR-179275 |
| PTPRO | STAT3 | Ser727 | NTIDLPMsPRTLDSL | dephosphorylation down-regulates activity | 24708807 | SIGNOR-277061 |
| SRC | STAT3 | – | phosphorylation up-regulates activity | 9566874 | SIGNOR-235445 | |
| EGFR | STAT3 | – | phosphorylation up-regulates activity | 22693070 | SIGNOR-235692 | |
| PK | STAT3 | – | phosphorylation up-regulates activity | 22306293 | SIGNOR-268149 | |
| PKM | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | phosphorylation up-regulates activity | 22306293 | SIGNOR-267716 |
| MTOR | STAT3 | Ser727 | NTIDLPMsPRTLDSL | phosphorylation up-regulates | 18691976 | SIGNOR-161439 |
| DYRK1A | STAT3 | Ser727 | NTIDLPMsPRTLDSL | phosphorylation up-regulates activity | 31454149 | SIGNOR-279992 |
| JAK2 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | phosphorylation up-regulates activity | 9575217 | SIGNOR-238638 |
| TNK2 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | phosphorylation up-regulates activity | 28739485 | SIGNOR-279312 |
| MTOR | STAT3 | Ser727 | NTIDLPMsPRTLDSL | phosphorylation up-regulates | 16740698 | SIGNOR-146915 |
| PPP1CA | STAT3 | Ser727 | NTIDLPMsPRTLDSL | dephosphorylation down-regulates activity | 19440292 | SIGNOR-248563 |
| FGFR4 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | phosphorylation up-regulates activity | 10918587 | SIGNOR-251142 |
| PTPRD | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | dephosphorylation down-regulates | 19478061 | SIGNOR-185933 |
| MAPK14 | STAT3 | Ser727 | NTIDLPMsPRTLDSL | phosphorylation up-regulates | 18691976 | SIGNOR-179912 |
| BUB1 | STAT3 | Ser727 | NTIDLPMsPRTLDSL | phosphorylation up-regulates activity | 34852826 | SIGNOR-280198 |
| MDK | STAT3 | – | phosphorylation up-regulates activity | 20431264 | SIGNOR-282594 | |
| DUSP3 | STAT3 | – | dephosphorylation down-regulates activity | 32475380 | SIGNOR-277070 | |
| HCK | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | phosphorylation up-regulates activity | 12244095 | SIGNOR-251267 |
| JAK1 | STAT3 | – | phosphorylation up-regulates activity | 26260587 | SIGNOR-253590 | |
| EIF2AK2 | STAT3 | Ser727 | NTIDLPMsPRTLDSL | phosphorylation up-regulates activity | 25360179 | SIGNOR-279612 |
| RPS6KA5 | STAT3 | Ser727 | NTIDLPMsPRTLDSL | phosphorylation up-regulates | 12763138 | SIGNOR-101251 |
| DUSP22 | STAT3 | – | dephosphorylation down-regulates activity | 16636663 | SIGNOR-277149 | |
| TYK2 | STAT3 | – | phosphorylation up-regulates | 30029643 | SIGNOR-256255 | |
| LEPR | STAT3 | – | phosphorylation up-regulates activity | 18718905 | SIGNOR-263492 | |
| MAPK8 | STAT3 | Ser727 | NTIDLPMsPRTLDSL | phosphorylation up-regulates activity | 23255093 | SIGNOR-235704 |
| MAPK3 | STAT3 | Ser727 | NTIDLPMsPRTLDSL | phosphorylation up-regulates | 14551213 | SIGNOR-118596 |
| PTPN14 | STAT3 | – | dephosphorylation down-regulates activity | 35259601 | SIGNOR-277088 | |
| SYK | STAT3 | – | phosphorylation up-regulates activity | 26848618 | SIGNOR-279298 | |
| MAPK3 | STAT3 | Ser727 | NTIDLPMsPRTLDSL | phosphorylation up-regulates | 19723038 | SIGNOR-187779 |
| IRAK1 | STAT3 | Ser727 | NTIDLPMsPRTLDSL | phosphorylation up-regulates | 15465816 | SIGNOR-129685 |
| EML4-ALK | STAT3 | – | phosphorylation up-regulates activity | 21415216 | SIGNOR-259203 | |
| PTK6 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | phosphorylation up-regulates activity | 26247733 | SIGNOR-278346 |
| PTPN2 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | dephosphorylation down-regulates activity | 15780598 | SIGNOR-93998 |
| FES | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | phosphorylation up-regulates activity | 15003822 | SIGNOR-278937 |
| PTPN1 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | dephosphorylation down-regulates activity | 15821101 | SIGNOR-248427 |
| JAK2 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | phosphorylation up-regulates activity | 9575217 | SIGNOR-236463 |
| BMX | STAT3 | – | phosphorylation up-regulates activity | 22348200 | SIGNOR-279497 | |
| TYK2 | STAT3 | – | phosphorylation up-regulates | 10542297 | SIGNOR-71781 | |
| STK3 | STAT3 | Thr622 | KEGGVTFtWVEKDIS | phosphorylation down-regulates activity | 35722967 | SIGNOR-277599 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP3K1 | phosphorylation up-regulates → | STAT3 PSer727 | phosphorylation up-regulates → | STAT3 | 17563747 | SIGNOR-236346 |
| EIF2AK2 | phosphorylation up-regulates → | STAT3 PTyr705 | phosphorylation up-regulates → | STAT3 | 25360179 | SIGNOR-279613 |
| FGFR3 | phosphorylation up-regulates → | STAT3 PTyr705 | phosphorylation up-regulates → | STAT3 | 10918587 | SIGNOR-251139 |
| MAPK3 | phosphorylation up-regulates → | STAT3 PTyr705 | phosphorylation up-regulates → | STAT3 | 14551213 | SIGNOR-118600 |
| NEK6 | phosphorylation up-regulates → | STAT3 PTyr705 | phosphorylation up-regulates → | STAT3 | 20595392 | SIGNOR-273901 |
| PKM | phosphorylation up-regulates → | STAT3 PTyr705 | phosphorylation up-regulates → | STAT3 | 22306293 | SIGNOR-195766 |
| NEK6 | phosphorylation up-regulates → | STAT3 PSer727 | phosphorylation up-regulates → | STAT3 | 20595392 | SIGNOR-273902 |
| PTPRR | dephosphorylation down-regulates ⊣ | STAT3 PTyr705 | dephosphorylation up-regulates → | STAT3 | 17360477 | SIGNOR-248719 |
| MAP3K14 | phosphorylation up-regulates → | STAT3 PSer727 | phosphorylation up-regulates → | STAT3 | 17543278 | SIGNOR-279340 |
| PTPRT | dephosphorylation down-regulates ⊣ | STAT3 PTyr705 | dephosphorylation up-regulates → | STAT3 | 17360477 | SIGNOR-263981 |
| PTPN4 | dephosphorylation down-regulates ⊣ | STAT3 PTyr705 | dephosphorylation up-regulates → | STAT3 | 31025789 | SIGNOR-277057 |
| PK | phosphorylation up-regulates → | STAT3 PTyr705 | phosphorylation up-regulates → | STAT3 | 22306293 | SIGNOR-268152 |
| ABL1 | phosphorylation up-regulates → | STAT3 PTyr705 | phosphorylation up-regulates → | STAT3 | 23383209 | SIGNOR-279675 |
| PTPRG | dephosphorylation down-regulates ⊣ | STAT3 PTyr705 | dephosphorylation down-regulates ⊣ | STAT3 | 25624455 | SIGNOR-254729 |
| MAP3K14 | phosphorylation up-regulates → | STAT3 PTyr705 | phosphorylation up-regulates → | STAT3 | 17543278 | SIGNOR-279341 |
| PTPN9 | dephosphorylation down-regulates ⊣ | STAT3 PTyr705 | dephosphorylation up-regulates → | STAT3 | 22394684 | SIGNOR-276976 |
| PTPN1 | dephosphorylation down-regulates ⊣ | STAT3 PTyr705 | dephosphorylation up-regulates → | STAT3 | 15821101 | SIGNOR-135211 |
| PTPN11 | dephosphorylation down-regulates ⊣ | STAT3 PTyr705 | dephosphorylation up-regulates → | STAT3 | 16611743 | SIGNOR-272404 |
| RET/PTC2 | phosphorylation up-regulates → | STAT3 PTyr705 | phosphorylation up-regulates → | STAT3 | 12637586 | SIGNOR-260917 |
| MAPK3 | phosphorylation up-regulates → | STAT3 PTyr705 | phosphorylation up-regulates → | STAT3 | 19723038 | SIGNOR-187787 |
| JAK1 | phosphorylation up-regulates → | STAT3 PTyr705 | phosphorylation up-regulates → | STAT3 | 19723038 | SIGNOR-187775 |
| CDK5 | phosphorylation up-regulates → | STAT3 PSer727 | phosphorylation up-regulates → | STAT3 | 15096606 | SIGNOR-124325 |
| PRKCE | phosphorylation up-regulates → | STAT3 PSer727 | phosphorylation up-regulates → | STAT3 | 16418226 | SIGNOR-143832 |
| MAPK3 | phosphorylation up-regulates → | STAT3 PSer727 | phosphorylation up-regulates → | STAT3 | 14551213 | SIGNOR-249450 |
| DAPK3 | phosphorylation up-regulates → | STAT3 PSer727 | phosphorylation up-regulates → | STAT3 | 16219639 | SIGNOR-279702 |
| PTPRK | dephosphorylation down-regulates ⊣ | STAT3 PTyr705 | dephosphorylation up-regulates → | STAT3 | 25612622 | SIGNOR-277060 |
| PTPRD | dephosphorylation down-regulates ⊣ | STAT3 PTyr705 | dephosphorylation up-regulates → | STAT3 | 19478061 | SIGNOR-248442 |
| PRKCD | phosphorylation up-regulates → | STAT3 PSer727 | phosphorylation up-regulates → | STAT3 | 16418226 | SIGNOR-143828 |
| PTPRO | dephosphorylation down-regulates ⊣ | STAT3 PTyr705 | dephosphorylation up-regulates → | STAT3 | 24708807 | SIGNOR-277062 |
| JAK1 | phosphorylation up-regulates → | STAT3 PTyr705 | phosphorylation up-regulates → | STAT3 | 26260587 | SIGNOR-249546 |
| PTPN2 | dephosphorylation down-regulates ⊣ | STAT3 PTyr705 | dephosphorylation up-regulates → | STAT3 | 12138178 | SIGNOR-90818 |
| NLK | phosphorylation up-regulates → | STAT3 PSer727 | phosphorylation up-regulates → | STAT3 | 17563747 | SIGNOR-155828 |
| PTPRM | dephosphorylation down-regulates ⊣ | STAT3 PTyr705 | dephosphorylation up-regulates → | STAT3 | 31900385 | SIGNOR-277016 |
| SRC | phosphorylation up-regulates → | STAT3 PTyr705 | phosphorylation up-regulates → | STAT3 | 14551213 | SIGNOR-247341 |
| MAPK14 | phosphorylation up-regulates → | STAT3 PSer727 | phosphorylation up-regulates → | STAT3 | 17502367 | SIGNOR-154783 |
| MAPK9 | phosphorylation up-regulates → | STAT3 PSer727 | phosphorylation up-regulates → | STAT3 | 18691976 | SIGNOR-179275 |
| PTPRO | dephosphorylation down-regulates ⊣ | STAT3 PSer727 | dephosphorylation up-regulates → | STAT3 | 24708807 | SIGNOR-277061 |
| PKM | phosphorylation up-regulates → | STAT3 PTyr705 | phosphorylation up-regulates → | STAT3 | 22306293 | SIGNOR-267716 |
| MTOR | phosphorylation up-regulates → | STAT3 PSer727 | phosphorylation up-regulates → | STAT3 | 18691976 | SIGNOR-161439 |
| DYRK1A | phosphorylation up-regulates → | STAT3 PSer727 | phosphorylation up-regulates → | STAT3 | 31454149 | SIGNOR-279992 |
| JAK2 | phosphorylation up-regulates → | STAT3 PTyr705 | phosphorylation up-regulates → | STAT3 | 9575217 | SIGNOR-238638 |
| TNK2 | phosphorylation up-regulates → | STAT3 PTyr705 | phosphorylation up-regulates → | STAT3 | 28739485 | SIGNOR-279312 |
| MTOR | phosphorylation up-regulates → | STAT3 PSer727 | phosphorylation up-regulates → | STAT3 | 16740698 | SIGNOR-146915 |
| PPP1CA | dephosphorylation down-regulates ⊣ | STAT3 PSer727 | dephosphorylation up-regulates → | STAT3 | 19440292 | SIGNOR-248563 |
| FGFR4 | phosphorylation up-regulates → | STAT3 PTyr705 | phosphorylation up-regulates → | STAT3 | 10918587 | SIGNOR-251142 |
| PTPRD | dephosphorylation down-regulates ⊣ | STAT3 PTyr705 | dephosphorylation up-regulates → | STAT3 | 19478061 | SIGNOR-185933 |
| MAPK14 | phosphorylation up-regulates → | STAT3 PSer727 | phosphorylation up-regulates → | STAT3 | 18691976 | SIGNOR-179912 |
| BUB1 | phosphorylation up-regulates → | STAT3 PSer727 | phosphorylation up-regulates → | STAT3 | 34852826 | SIGNOR-280198 |
| HCK | phosphorylation up-regulates → | STAT3 PTyr705 | phosphorylation up-regulates → | STAT3 | 12244095 | SIGNOR-251267 |
| EIF2AK2 | phosphorylation up-regulates → | STAT3 PSer727 | phosphorylation up-regulates → | STAT3 | 25360179 | SIGNOR-279612 |
| RPS6KA5 | phosphorylation up-regulates → | STAT3 PSer727 | phosphorylation up-regulates → | STAT3 | 12763138 | SIGNOR-101251 |
| MAPK8 | phosphorylation up-regulates → | STAT3 PSer727 | phosphorylation up-regulates → | STAT3 | 23255093 | SIGNOR-235704 |
| MAPK3 | phosphorylation up-regulates → | STAT3 PSer727 | phosphorylation up-regulates → | STAT3 | 14551213 | SIGNOR-118596 |
| MAPK3 | phosphorylation up-regulates → | STAT3 PSer727 | phosphorylation up-regulates → | STAT3 | 19723038 | SIGNOR-187779 |
| IRAK1 | phosphorylation up-regulates → | STAT3 PSer727 | phosphorylation up-regulates → | STAT3 | 15465816 | SIGNOR-129685 |
| PTK6 | phosphorylation up-regulates → | STAT3 PTyr705 | phosphorylation up-regulates → | STAT3 | 26247733 | SIGNOR-278346 |
| PTPN2 | dephosphorylation down-regulates ⊣ | STAT3 PTyr705 | dephosphorylation up-regulates → | STAT3 | 15780598 | SIGNOR-93998 |
| FES | phosphorylation up-regulates → | STAT3 PTyr705 | phosphorylation up-regulates → | STAT3 | 15003822 | SIGNOR-278937 |
| PTPN1 | dephosphorylation down-regulates ⊣ | STAT3 PTyr705 | dephosphorylation up-regulates → | STAT3 | 15821101 | SIGNOR-248427 |
| JAK2 | phosphorylation up-regulates → | STAT3 PTyr705 | phosphorylation up-regulates → | STAT3 | 9575217 | SIGNOR-236463 |
| STK3 | phosphorylation up-regulates → | STAT3 PThr622 | phosphorylation down-regulates ⊣ | STAT3 | 35722967 | SIGNOR-277599 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAP3K1 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-236346 |
| MAPK1 | phosphorylation → down-regulates activity | STAT3 | SIGNOR-279635 |
| EIF2AK2 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-279613 |
| FGFR3 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-251139 |
| MAPK3 | phosphorylation → up-regulates | STAT3 | SIGNOR-118600 |
| MET | phosphorylation → up-regulates activity | STAT3 | SIGNOR-280041 |
| NEK6 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-273901 |
| PKM | phosphorylation → up-regulates | STAT3 | SIGNOR-195766 |
| NEK6 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-273902 |
| LCK | phosphorylation → up-regulates activity | STAT3 | SIGNOR-279201 |
| PTPRR | dephosphorylation → down-regulates activity | STAT3 | SIGNOR-248719 |
| PTPN6 | dephosphorylation down-regulates | STAT3 | SIGNOR-178699 |
| MAP3K14 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-279340 |
| PTPRT | dephosphorylation → down-regulates activity | STAT3 | SIGNOR-263981 |
| PTPN4 | dephosphorylation → down-regulates activity | STAT3 | SIGNOR-277057 |
| EGFR | phosphorylation → up-regulates activity | STAT3 | SIGNOR-121965 |
| LYN | phosphorylation → up-regulates activity | STAT3 | SIGNOR-279062 |
| PK | phosphorylation → up-regulates | STAT3 | SIGNOR-268152 |
| EPHB1 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-279709 |
| ABL1 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-279675 |
| PTPRG | dephosphorylation → up-regulates activity | STAT3 | SIGNOR-254729 |
| BTK | phosphorylation → down-regulates activity | STAT3 | SIGNOR-279011 |
| MAP3K14 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-279341 |
| PTPN9 | dephosphorylation → down-regulates activity | STAT3 | SIGNOR-276976 |
| ALK | phosphorylation → up-regulates activity | STAT3 | SIGNOR-279319 |
| PTPN1 | dephosphorylation down-regulates | STAT3 | SIGNOR-135211 |
| FER | phosphorylation → up-regulates activity | STAT3 | SIGNOR-279713 |
| RPS6KA5 | phosphorylation → up-regulates | STAT3 | SIGNOR-166664 |
| PTPN11 | dephosphorylation → down-regulates activity | STAT3 | SIGNOR-272404 |
| RET/PTC2 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-260917 |
| MAPK3 | phosphorylation → up-regulates | STAT3 | SIGNOR-187787 |
| PK | phosphorylation → up-regulates activity | STAT3 | SIGNOR-270312 |
| JAK1 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-187775 |
| PTPRT | dephosphorylation → down-regulates activity | STAT3 | SIGNOR-277043 |
| CDK5 | phosphorylation → up-regulates | STAT3 | SIGNOR-124325 |
| PRKCE | phosphorylation → up-regulates | STAT3 | SIGNOR-143832 |
| JAK3 | phosphorylation → up-regulates | STAT3 | SIGNOR-256254 |
| MAPK3 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-249450 |
| PTK2B | phosphorylation → up-regulates activity | STAT3 | SIGNOR-279429 |
| DAPK3 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-279702 |
| PTPRK | dephosphorylation → down-regulates activity | STAT3 | SIGNOR-277060 |
| PTPRD | dephosphorylation → down-regulates activity | STAT3 | SIGNOR-248442 |
| PRKCD | phosphorylation → up-regulates | STAT3 | SIGNOR-143828 |
| PTPRO | dephosphorylation → down-regulates activity | STAT3 | SIGNOR-277062 |
| JAK1 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-249546 |
| PTPN2 | dephosphorylation down-regulates | STAT3 | SIGNOR-90818 |
| NLK | phosphorylation → up-regulates | STAT3 | SIGNOR-155828 |
| PTPRM | dephosphorylation → down-regulates activity | STAT3 | SIGNOR-277016 |
| SRC | phosphorylation → up-regulates activity | STAT3 | SIGNOR-247341 |
| MAPK14 | phosphorylation → up-regulates | STAT3 | SIGNOR-154783 |
| MAPK9 | phosphorylation → up-regulates | STAT3 | SIGNOR-179275 |
| PTPRO | dephosphorylation → down-regulates activity | STAT3 | SIGNOR-277061 |
| SRC | phosphorylation → up-regulates activity | STAT3 | SIGNOR-235445 |
| EGFR | phosphorylation → up-regulates activity | STAT3 | SIGNOR-235692 |
| PK | phosphorylation → up-regulates activity | STAT3 | SIGNOR-268149 |
| PKM | phosphorylation → up-regulates activity | STAT3 | SIGNOR-267716 |
| MTOR | phosphorylation → up-regulates | STAT3 | SIGNOR-161439 |
| DYRK1A | phosphorylation → up-regulates activity | STAT3 | SIGNOR-279992 |
| JAK2 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-238638 |
| TNK2 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-279312 |
| MTOR | phosphorylation → up-regulates | STAT3 | SIGNOR-146915 |
| PPP1CA | dephosphorylation → down-regulates activity | STAT3 | SIGNOR-248563 |
| FGFR4 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-251142 |
| PTPRD | dephosphorylation down-regulates | STAT3 | SIGNOR-185933 |
| MAPK14 | phosphorylation → up-regulates | STAT3 | SIGNOR-179912 |
| BUB1 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-280198 |
| MDK | phosphorylation → up-regulates activity | STAT3 | SIGNOR-282594 |
| DUSP3 | dephosphorylation → down-regulates activity | STAT3 | SIGNOR-277070 |
| HCK | phosphorylation → up-regulates activity | STAT3 | SIGNOR-251267 |
| JAK1 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-253590 |
| EIF2AK2 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-279612 |
| RPS6KA5 | phosphorylation → up-regulates | STAT3 | SIGNOR-101251 |
| DUSP22 | dephosphorylation → down-regulates activity | STAT3 | SIGNOR-277149 |
| TYK2 | phosphorylation → up-regulates | STAT3 | SIGNOR-256255 |
| LEPR | phosphorylation → up-regulates activity | STAT3 | SIGNOR-263492 |
| MAPK8 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-235704 |
| MAPK3 | phosphorylation → up-regulates | STAT3 | SIGNOR-118596 |
| PTPN14 | dephosphorylation → down-regulates activity | STAT3 | SIGNOR-277088 |
| SYK | phosphorylation → up-regulates activity | STAT3 | SIGNOR-279298 |
| MAPK3 | phosphorylation → up-regulates | STAT3 | SIGNOR-187779 |
| IRAK1 | phosphorylation → up-regulates | STAT3 | SIGNOR-129685 |
| EML4-ALK | phosphorylation → up-regulates activity | STAT3 | SIGNOR-259203 |
| PTK6 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-278346 |
| PTPN2 | dephosphorylation → down-regulates activity | STAT3 | SIGNOR-93998 |
| FES | phosphorylation → up-regulates activity | STAT3 | SIGNOR-278937 |
| PTPN1 | dephosphorylation → down-regulates activity | STAT3 | SIGNOR-248427 |
| JAK2 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-236463 |
| BMX | phosphorylation → up-regulates activity | STAT3 | SIGNOR-279497 |
| TYK2 | phosphorylation → up-regulates | STAT3 | SIGNOR-71781 |
| STK3 | phosphorylation → down-regulates activity | STAT3 | SIGNOR-277599 |