| + |
PPP1CA | down-regulates activity 
dephosphorylation
|
STAT3 |
0.335 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248563 |
Ser727 |
NTIDLPMsPRTLDSL |
Homo sapiens |
Hep-G2 Cell, U-266 Cell |
| pmid |
sentence |
| 19440292 |
Avicins dephosphorylate Stat3 in a variety of human tumor cell lines, leading to a decrease in the transcriptional activity of Stat3.| However, PD98059, an inhibitor of MEK1/2, had no significant effects on avicin-induced dephosphorylation of Stat3 (Ser 727) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK5 | up-regulates 
phosphorylation
|
STAT3 |
0.413 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-124325 |
Ser727 |
NTIDLPMsPRTLDSL |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 15096606 |
We report here that the cdk5/p35 complex associates with stat3 and phosphorylates stat3 on the ser-727 residue in vitro and in vivo. Ser phosphorylation of stat3 and transcription of stat3 target genes, such as c-fos and junb, in a cdk5-dependent manner. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Myotube, Brain |
| + |
IRAK1 | up-regulates
phosphorylation
|
STAT3 |
0.567 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-129685 |
Ser727 |
NTIDLPMsPRTLDSL |
Homo sapiens |
|
| pmid |
sentence |
| 15465816 |
Irak1 can directly use stat3 as a substrate and cause stat3 serine 727 phosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKCD | up-regulates
phosphorylation
|
STAT3 |
0.578 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-143828 |
Ser727 |
NTIDLPMsPRTLDSL |
Homo sapiens |
|
| pmid |
sentence |
| 16418226 |
Abrogation of pkcdelta activity inhibited insulin-induced stat3 phosphorylation, pkcdelta-stat3 association and nuclear translocation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPRO | down-regulates activity
dephosphorylation
|
STAT3 |
0.385 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277061 |
Ser727 |
NTIDLPMsPRTLDSL |
Homo sapiens |
|
| pmid |
sentence |
| 24708807 |
In addition, this group found that PTPRO dephosphorylated STAT3 at Y705 and S727 then attenuated STAT3 signalling. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277062 |
Tyr705 |
DPGSAAPyLKTKFIC |
Homo sapiens |
|
| pmid |
sentence |
| 24708807 |
In addition, this group found that PTPRO dephosphorylated STAT3 at Y705 and S727 then attenuated STAT3 signalling. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAPK3 | up-regulates
phosphorylation
|
STAT3 |
0.709 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-118596 |
Ser727 |
NTIDLPMsPRTLDSL |
Homo sapiens |
Leukemia Cell |
| pmid |
sentence |
| 14551213 |
The activation of stat-3 is regulated by phosphorylation of tyrosine 705 by receptor and nonreceptor protein tyrosine kinases these include epidermal growth factor receptor (egfr) kinase,92 src,5 janus-activated kinases (jak), and extracellular signal-regulated kinase (erk)a constitutively active galpha16 mutant, galpha16ql, stimulated stat3-dependent luciferase activity as well as the phosphorylation of stat3 at both tyr705 and ser727. Galpha16ql-induced stat3 activation was enhanced by overexpression of extracellular signal-regulated kinase 1 (erk1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-187779 |
Ser727 |
NTIDLPMsPRTLDSL |
Homo sapiens |
|
| pmid |
sentence |
| 19723038 |
The activation of stat-3 is regulated by phosphorylation of tyrosine 705 by receptor and nonreceptor protein tyrosine kinases these include epidermal growth factor receptor (egfr) kinase,92 src,5 janus-activated kinases (jak), and extracellular signal-regulated kinase (erk)a constitutively active galpha16 mutant, galpha16ql, stimulated stat3-dependent luciferase activity as well as the phosphorylation of stat3 at both tyr705 and ser727. Galpha16ql-induced stat3 activation was enhanced by overexpression of extracellular signal-regulated kinase 1 (erk1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-187787 |
Tyr705 |
DPGSAAPyLKTKFIC |
Homo sapiens |
|
| pmid |
sentence |
| 19723038 |
The activation of stat-3 is regulated by phosphorylation of tyrosine 705 by receptor and nonreceptor protein tyrosine kinases these include epidermal growth factor receptor (egfr) kinase,92 src,5 janus-activated kinases (jak), and extracellular signal-regulated kinase (erk)a constitutively active galpha16 mutant, galpha16ql, stimulated stat3-dependent luciferase activity as well as the phosphorylation of stat3 at both tyr705 and ser727. Galpha16ql-induced stat3 activation was enhanced by overexpression of extracellular signal-regulated kinase 1 (erk1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-118600 |
Tyr705 |
DPGSAAPyLKTKFIC |
Homo sapiens |
Leukemia Cell |
| pmid |
sentence |
| 14551213 |
The activation of stat-3 is regulated by phosphorylation of tyrosine 705 by receptor and nonreceptor protein tyrosine kinases these include epidermal growth factor receptor (egfr) kinase,92 src,5 janus-activated kinases (jak), and extracellular signal-regulated kinase (erk)a constitutively active galpha16 mutant, galpha16ql, stimulated stat3-dependent luciferase activity as well as the phosphorylation of stat3 at both tyr705 and ser727. Galpha16ql-induced stat3 activation was enhanced by overexpression of extracellular signal-regulated kinase 1 (erk1 |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| Tissue: |
Kidney |
| + |
MAP3K1 | up-regulates activity
phosphorylation
|
STAT3 |
0.296 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236346 |
Ser727 |
NTIDLPMsPRTLDSL |
Homo sapiens |
|
| pmid |
sentence |
| 17563747 |
Phosphorylation of s727 induces pin1 binding which increases transcription. Pin1 binding increases stat3 interaction with p300 and dna. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EGFR Signaling, EBV infection, Macrophage polarization |
| + |
NEK6 | up-regulates activity
phosphorylation
|
STAT3 |
0.34 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273902 |
Ser727 |
NTIDLPMsPRTLDSL |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20595392 |
Our data also show that NEK6 interacts with STAT3, an oncogenic transcription factor, and phosphorylates STAT3 on Ser(727), which is important for transcriptional activation. These results demonstrate that NEK6 interacts with and phosphorylates STAT3, an event that could play an important role in oncogenesis. For the maximal activation of STAT3 signaling, phosphorylation of both Tyr705 and Ser727 is required. Phosphorylation of Tyr705 induces dimerization, nuclear translocation, and DNA binding of the STAT3 protein, whereas phosphorylation of Ser727 is important for transcriptional activation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273901 |
Tyr705 |
DPGSAAPyLKTKFIC |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20595392 |
Our data also show that NEK6 interacts with STAT3, an oncogenic transcription factor, and phosphorylates STAT3 on Ser(727), which is important for transcriptional activation. These results demonstrate that NEK6 interacts with and phosphorylates STAT3, an event that could play an important role in oncogenesis. For the maximal activation of STAT3 signaling, phosphorylation of both Tyr705 and Ser727 is required. Phosphorylation of Tyr705 induces dimerization, nuclear translocation, and DNA binding of the STAT3 protein, whereas phosphorylation of Ser727 is important for transcriptional activation. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MTOR | up-regulates
phosphorylation
|
STAT3 |
0.738 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-161439 |
Ser727 |
NTIDLPMsPRTLDSL |
Homo sapiens |
|
| pmid |
sentence |
| 18691976 |
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-146915 |
Ser727 |
NTIDLPMsPRTLDSL |
Homo sapiens |
Glioblastoma Cell |
| pmid |
sentence |
| 16740698 |
Serine phosphorylation and maximal activation of stat3 during cntf signaling is mediated by the rapamycin target mtor. / a stat3 peptide was efficiently phosphorylated on ser727 in a cntf-dependent manner by mtor |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, KIT in AML, FLT3-ITD signaling, Leptin Signaling, Pancreatic ductal adenocarcinoma (PDA) |
| + |
RPS6KA5 | up-regulates
phosphorylation
|
STAT3 |
0.393 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-101251 |
Ser727 |
NTIDLPMsPRTLDSL |
Homo sapiens |
|
| pmid |
sentence |
| 12763138 |
The stat3-mediated transactivation was reduced by blocking the stat3 serine phosphorylation with the mek inhibitor u0126 or by expression of kinase-inactive msk1. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-166664 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20626350 |
Msk (mitogen- and stress-activated kinase) 1 and 2 can directly phosphorylate and activate transcription factors such as creb, atf1, the nf- b isoform p65 and stat (signal transducer and activator of transcription) 1 and 3 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | up-regulates
phosphorylation
|
STAT3 |
0.606 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-179912 |
Ser727 |
NTIDLPMsPRTLDSL |
Homo sapiens |
|
| pmid |
sentence |
| 18691976 |
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-154783 |
Ser727 |
NTIDLPMsPRTLDSL |
Homo sapiens |
|
| pmid |
sentence |
| 17502367 |
All stats are phosphorylated on at least one serine residue in their tad specifically, ser727 in stats 1 and 3 and ser721 in stat4. Stat serine kinases have been identified through the use of inhibitors, dominant-negative alleles, and in vitro kinase assays. They include mapk (p38mapk: stats 1, 3, 4;erk: stat3, 5;jnk: stat3), pkc_ (stat1, stat3), mtor (stat3), nlk (stat3 (42)), and camkii and ikk_ (stat1 (39, 40, 43)).STAT Serine phosphorylation regulates transcriptional activity (see below). |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling |
| + |
MAPK3 | up-regulates activity
phosphorylation
|
STAT3 |
0.709 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249450 |
Ser727 |
NTIDLPMsPRTLDSL |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 14551213 |
The hematopoietic-specific Galpha16 protein has recently been shown to mediate receptor-induced activation of the signal transducer and activator of transcription 3 (STAT3). In the present study, we have delineated the mechanism by which Galpha16 stimulates STAT3 in human embryonic kidney 293 cells. A constitutively active Galpha16 mutant, Galpha16QL, stimulated STAT3-dependent luciferase activity as well as the phosphorylation of STAT3 at both Tyr705 and Ser727. Galpha16QL-induced STAT3 activation was enhanced by overexpression of extracellular signal-regulated kinase 1 (ERK1), |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK8 | up-regulates activity
phosphorylation
|
STAT3 |
0.585 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235704 |
Ser727 |
NTIDLPMsPRTLDSL |
Homo sapiens |
BEAS-2B Cell |
| pmid |
sentence |
| 23255093 |
Transfection of the cells with sirna specific for jnk1 revealed that jnk silencing reduced serine727 phosphorylation of stat3, |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, EGFR Signaling, Macrophage polarization |
| + |
MAPK9 | up-regulates
phosphorylation
|
STAT3 |
0.495 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-179275 |
Ser727 |
NTIDLPMsPRTLDSL |
Homo sapiens |
|
| pmid |
sentence |
| 18691976 |
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NLK | up-regulates
phosphorylation
|
STAT3 |
0.354 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-155828 |
Ser727 |
NTIDLPMsPRTLDSL |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 17563747 |
Phosphorylation of s727 induces pin1 binding which increases transcription. Pin1 binding increases stat3 interaction with p300 and dna. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKCE | up-regulates
phosphorylation
|
STAT3 |
0.409 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-143832 |
Ser727 |
NTIDLPMsPRTLDSL |
Homo sapiens |
|
| pmid |
sentence |
| 16418226 |
Abrogation of pkcdelta activity inhibited insulin-induced stat3 phosphorylation, pkcdelta-stat3 association and nuclear translocation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skin |
| + |
STK3 | down-regulates activity
phosphorylation
|
STAT3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277599 |
Thr622 |
KEGGVTFtWVEKDIS |
in vitro |
|
| pmid |
sentence |
| 35722967 |
Hippo pathway component MST2 kinase phosphorylates STAT3 at T622, which is located in the SH2 domain of STAT3. This phosphorylation blocks the SH2 domain in one STAT3 molecule to bind with the phosphorylated Y705 site in another STAT3 molecule, which further counteracts IL6-induced STAT3 dimerization and activation. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
PK | up-regulates
phosphorylation
|
STAT3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268152 |
Tyr705 |
DPGSAAPyLKTKFIC |
Homo sapiens |
|
| pmid |
sentence |
| 22306293 |
Pkm2 activates transcription of mek5 by phosphorylating stat3 at y705. pkm2 regulates mek5 transcription via activation of stat3 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FGFR3 | up-regulates activity
phosphorylation
|
STAT3 |
0.615 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251139 |
Tyr705 |
DPGSAAPyLKTKFIC |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 10918587 |
Activation of Stat1 and Stat3 by FGFR derivatives. Lysates of 293T cells transfected as indicated were analysed by Western blotting using Phospho-Stat1 (Y701) antisera (top) or Stat1 antisera (bottom). (b) The same lysates in (a) were re-examined for phosphorylated Stat3 by Western blotting with Phospho-Stat3 (Y705) (top). all three FGFR family members examined here are able to lead to Stat activation. Expression of the 'TDII-like' derivatives of FGFR1, FGFR3, and FGFR4, as well as myrR1-WT, led to phosphorylation of both Stat1 and Stat3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
JAK2 | up-regulates activity
phosphorylation
|
STAT3 |
0.812 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236463 |
Tyr705 |
DPGSAAPyLKTKFIC |
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 9575217 |
Activation of wild type stat3: il-6 treatment causes stat3 recruitment to receptor tyrosine phosphopeptides (gp130) where it is phosphorylated on tyrosine 705 (y) by jak kinase |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-238638 |
Tyr705 |
DPGSAAPyLKTKFIC |
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 9575217 |
Inactive cytoplasmic STATs are recruited to the activated receptor by docking of the STAT SH2 domain to selected receptor tyrosine phosphopeptides, where they are in turn phosphorylated on a single tyrosine by Jak kinases. Has been identified tyrosine 705 of Stat3 as the likely site of phosphorylation by Jak kinases during signal transduction. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, KIT in AML, EGFR Signaling, EBV infection, Leptin Signaling, Macrophage polarization |
| + |
PTPRK | down-regulates activity
dephosphorylation
|
STAT3 |
0.383 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277060 |
Tyr705 |
DPGSAAPyLKTKFIC |
Homo sapiens |
|
| pmid |
sentence |
| 25612622 |
In this study, we investigated whether receptor-type tyrosine protein phosphatase kappa (PTPRK), the only protein tyrosine phosphatase at 6q that contains a STAT3 specifying motif, negatively regulates STAT3 activation in NKTCL.|Phosphatase substrate-trapping mutant assays demonstrated the binding of PTPRK to STAT3, and phosphatase assays showed that PTPRK directly dephosphorylated phospho-STAT3(Tyr705). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPN1 | down-regulates activity
dephosphorylation
|
STAT3 |
0.569 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248427 |
Tyr705 |
DPGSAAPyLKTKFIC |
Homo sapiens |
|
| pmid |
sentence |
| 15821101 |
PTP1B was able to dephosphorylate activated JAK2 and STAT3 in vitro, whereas either no or a minimal effect was observed with cluster of differentiation 45 (CD45), PTPalpha and leukocyte antigen-related (LAR). By utilisation of a selective PTP1B inhibitor, the leptin-induced STAT3 activation was enhanced in cells. In conclusion, these results suggested that the negative regulatory role of PTP1B on leptin signalling is mediated through a direct and selective dephosphorylation of the two signalling molecules, JAK2 and STAT3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PKM | up-regulates
phosphorylation
|
STAT3 |
0.457 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-195766 |
Tyr705 |
DPGSAAPyLKTKFIC |
Homo sapiens |
|
| pmid |
sentence |
| 22306293 |
Pkm2 activates transcription of mek5 by phosphorylating stat3 at y705. pkm2 regulates mek5 transcription via activation of stat3 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling |
| + |
FGFR4 | up-regulates activity
phosphorylation
|
STAT3 |
0.411 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251142 |
Tyr705 |
DPGSAAPyLKTKFIC |
Homo sapiens |
|
| pmid |
sentence |
| 10918587 |
Activation of Stat1 and Stat3 by FGFR derivatives. Lysates of 293T cells transfected as indicated were analysed by Western blotting using Phospho-Stat1 (Y701) antisera (top) or Stat1 antisera (bottom). (b) The same lysates in (a) were re-examined for phosphorylated Stat3 by Western blotting with Phospho-Stat3 (Y705) (top). all three FGFR family members examined here are able to lead to Stat activation. Expression of the 'TDII-like' derivatives of FGFR1, FGFR3, and FGFR4, as well as myrR1-WT, led to phosphorylation of both Stat1 and Stat3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Rhabdomyosarcoma |
| + |
PTPRR | down-regulates activity
dephosphorylation
|
STAT3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248719 |
Tyr705 |
DPGSAAPyLKTKFIC |
Homo sapiens |
Colorectal Cancer Cell Line |
| pmid |
sentence |
| 17360477 |
Here, we report identification of signal transducer and activator of transcription 3 (STAT3) as a substrate of PTPRT. Phosphorylation of a tyrosine at amino acid Y705 is essential for the function of STAT3, and PTPRT specifically dephosphorylated STAT3 at this position. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPN1 | down-regulates
dephosphorylation
|
STAT3 |
0.569 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-135211 |
Tyr705 |
DPGSAAPyLKTKFIC |
Homo sapiens |
|
| pmid |
sentence |
| 15821101 |
Mechanism of protein tyrosine phosphatase 1b-mediated inhibition of leptin signalling. Ptp1b plays a critical role in the down-regulation of activated-stat3 by dephosphorylating tyr705, that is the phosphorylation site of activation of stat3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
JAK1 | up-regulates activity
phosphorylation, binding
|
STAT3 |
0.793 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249546 |
Tyr705 |
DPGSAAPyLKTKFIC |
Mus musculus |
|
| pmid |
sentence |
| 26260587 |
IL10R2 recruits cytoplasmic protein Jak1 followed by phosphorylation of tyrosine at position 705 in the STAT3 (705Y-STAT3) molecule. Phosphorylated STAT3 forms a homodimer, which is then translocated to the nucleus to facilitate transcriptional regulation of target genes. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-187775 |
Tyr705 |
DPGSAAPyLKTKFIC |
Homo sapiens |
|
| pmid |
sentence |
| 19723038 |
The activation of stat-3 is regulated by phosphorylation of tyrosine 705 by receptor and nonreceptor protein tyrosine kinases. These include epidermal growth factor receptor (egfr) kinase, src, janus-activated kinases (jak), and extracellular signal-regulated kinase (erk). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236369 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24710148 |
The binding of lif to the lifr induces its heterodimerization with gp130. The formation of this complex results in the activation of the receptor-associated janus kinases (jaks), in the phosphorylation of receptor docking sites, and finally in the recruitment of src homology-2 (sh2) domain containing proteins such as stat3 (signal transducer and activator of transcription 3). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253590 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26260587 |
IL10R2 recruits cytoplasmic protein Jak1 followed by phosphorylation of tyrosine at position 705 in the STAT3 (705Y-STAT3) molecule. Phosphorylated STAT3 forms a homodimer, which is then translocated to the nucleus to facilitate transcriptional regulation of target genes. |
|
| Publications: |
4 |
Organism: |
Mus Musculus, Homo Sapiens |
| Pathways: | EBV infection, IL6 Signaling, Multiple sclerosis, SARS-CoV CYTOKINE STORM |
| + |
PTPRD | down-regulates activity
dephosphorylation
|
STAT3 |
0.533 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248442 |
Tyr705 |
DPGSAAPyLKTKFIC |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 19478061 |
Transfection of wild-type PTPRD resulted in the specific dephosphorylation of STAT3 at tyrosine 705, a residue that must be phosphorylated for STAT3 to be active |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPRT | down-regulates activity
dephosphorylation
|
STAT3 |
0.531 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263981 |
Tyr705 |
DPGSAAPyLKTKFIC |
Homo sapiens |
HCT-116 Cell, HT-29 Cell |
| pmid |
sentence |
| 17360477 |
Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T|Phosphorylation of a tyrosine at amino acid Y705 is essential for the function of STAT3, and PTPRT specifically dephosphorylated STAT3 at this position. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277043 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17360477 |
Here, we report identification of signal transducer and activator of transcription 3 (STAT3) as a substrate of PTPRT. Phosphorylation of a tyrosine at amino acid Y705 is essential for the function of STAT3, and PTPRT specifically dephosphorylated STAT3 at this position. Accordingly, overexpression of normal PTPRT in colorectal cancer cells reduced the expression of STAT3 target genes.|Phosphorylation of a tyrosine at amino acid Y705 is essential for the function of STAT3, and PTPRT specifically dephosphorylated STAT3 at this position. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
RET/PTC2 | up-regulates activity
phosphorylation
|
STAT3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260917 |
Tyr705 |
DPGSAAPyLKTKFIC |
Homo sapiens |
|
| pmid |
sentence |
| 12637586 |
In addition, RET/PTC-mediated cellular transformation and proliferation of transformed cells require tyrosine 705 phosphorylation of STAT3 in NIH3T3 cells. We conclude that STAT3 activation by the RET/PTC tyrosine kinase is one of the critical signaling pathways for the regulation of specific genes, such as cyclin D1, vascular endothelial growth factor, and intercellular adhesion molecule 1, and for cellular transformation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HCK | up-regulates activity
phosphorylation
|
STAT3 |
0.601 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251267 |
Tyr705 |
DPGSAAPyLKTKFIC |
in vitro |
|
| pmid |
sentence |
| 12244095 |
Activation of STAT3 by the Src family kinase Hck requires a functional SH3 domain. Direct Phosphorylation of STAT3 on Tyr-705 by Src Family Kinases |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
PTPRG | up-regulates activity
dephosphorylation
|
STAT3 |
0.262 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254729 |
Tyr705 |
DPGSAAPyLKTKFIC |
in vitro |
|
| pmid |
sentence |
| 25624455 |
PTPRG activation by the P1-WD peptide affected the tyrosine phosphorylation of several signaling molecules. Data analysis identified 31 molecules whose phosphorylation was modified in a statistically significant manner (Table I). inhibition of ABL1, BMX, BTK, DAB1, ITGB1, JAK2, KDR, KIT, LIMK1, MET, PDGFRB, SHC1, and VCL correlates with tyrosine dephosphorylation. In contrast, SRC inhibition correlates with hyperphosphorylation of the inhibitory Tyr530 residue and with dephosphorylation of the activatory Tyr419. Moreover, CDK2 and CTTN inhibition correlates with a hyperphosphorylation of the inhibitory Tyr15 and Tyr470, respectively. In contrast, a subgroup of 13 proteins, including BLNK, DOK2, ERBB2, GRIN2B, INSR, PDGFRA, PRKCD, PXN, STAT1, STAT2, STAT3, STAT5A, and ZAP70, appears to be activated by PTPRG activity. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
PTPRD | down-regulates
dephosphorylation
|
STAT3 |
0.533 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-185933 |
Tyr705 |
DPGSAAPyLKTKFIC |
Homo sapiens |
Lung Cancer Cell, Glioblastoma Cell |
| pmid |
sentence |
| 19478061 |
Transfection of wild-type ptprd resulted in the specific dephosphorylation of stat3 at tyrosine 705, a residue that must be phosphorylated for stat3 to be active |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| + |
PKM | up-regulates activity
phosphorylation
|
STAT3 |
0.457 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267716 |
Tyr705 |
DPGSAAPyLKTKFIC |
in vitro |
|
| pmid |
sentence |
| 22306293 |
PKM2 activates transcription of MEK5 by phosphorylating stat3 at Y705. In vitro phosphorylation assays show that PKM2 is a protein kinase using PEP as a phosphate donor |
|
| Publications: |
1 |
Organism: |
In Vitro |
| Pathways: | FLT3-ITD signaling |
| + |
SRC | up-regulates activity
phosphorylation
|
STAT3 |
0.782 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-247341 |
Tyr705 |
DPGSAAPyLKTKFIC |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 14551213 |
In the present study, we have delineated the mechanism by which Galpha16 stimulates STAT3 in human embryonic kidney 293 cells. A constitutively active Galpha16 mutant, Galpha16QL, stimulated STAT3-dependent luciferase activity as well as the phosphorylation of STAT3 at both Tyr705 and Ser727.The involvement of tyrosine kinases such as c-Src and Janus kinase 2 and 3 (JAK2 and JAK3) in Galpha16QL-induced activation of STAT3 was illustrated by the combined use of selective inhibitors and dominant negative mutants. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235445 |
|
|
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 9566874 |
Previous studies have demonstrated that one STAT family member, Stat3, possesses constitutively elevated tyrosine phosphorylation and DNA-binding activity in fibroblasts stably transformed by the Src oncoprotein.We conclude that Stat3 activation by the Src oncoprotein leads to specific gene regulation and that Stat3 is one of the critical signaling pathways involved in Src oncogenesis. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, Mus Musculus |
| Pathways: | EGFR Signaling, IL6 Signaling, Rhabdomyosarcoma |
| + |
PTPN2 | down-regulates
dephosphorylation
|
STAT3 |
0.725 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-90818 |
Tyr705 |
DPGSAAPyLKTKFIC |
Homo sapiens |
|
| pmid |
sentence |
| 12138178 |
The nuclear isoform of protein-tyrosine phosphatase tc-ptp regulates interleukin-6-mediated signaling pathway through stat3 dephosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPN9 | down-regulates activity
dephosphorylation
|
STAT3 |
0.445 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276976 |
Tyr705 |
DPGSAAPyLKTKFIC |
Homo sapiens |
|
| pmid |
sentence |
| 22394684 |
Results are presented as mean \u00b1 SD from three independent experiments. (B) PTPMeg2 inhibits STAT3-mediated transcriptional activity in a dose dependent manner.|These results indicate that PTPMeg2 inhibits STAT3 activation with certain specificity.|In this study, we demonstrated that PTPMeg2 dephosphorylates STAT3 at the Tyr705 residue by a direct interaction. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPN2 | down-regulates activity
dephosphorylation
|
STAT3 |
0.725 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-93998 |
Tyr705 |
DPGSAAPyLKTKFIC |
Homo sapiens |
|
| pmid |
sentence |
| 15780598 |
Upon ligand binding, IL-2R , IL-6R or LeptinR , IFN-_R , IFN-_R and PRLR or growth hormone (GH) receptor associated JAKs become activated. These JAKs mediate phosphorylation of specific tyrosine residues and recruit STATs. Activated STATs are released from the receptor and translocate to the nucleus. PTP1B dephosphorylates JAK2, TYK2 and STAT5 . The 45-kDa form of TC-PTP was shown to dephosphorylate JAK1 and JAK3 as well as STAT1, STAT3 and STAT5. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPRM | down-regulates activity
dephosphorylation
|
STAT3 |
0.265 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277016 |
Tyr705 |
DPGSAAPyLKTKFIC |
Homo sapiens |
|
| pmid |
sentence |
| 31900385 |
Thus PTPRM suppresses STAT3 signaling in DDIAS-knockdown cells, suggesting that DDIAS promotes the IL-6\u2013mediated STAT3 signaling in malignant cancer cells by inhibiting the PTPRM function.|We report that PTPRM is a novel STAT3 tyrosine phosphatase and that it negatively regulates STAT3 activation by dephosphorylating Y705 of STAT3 in the presence of IL-6. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPN11 | down-regulates activity
dephosphorylation
|
STAT3 |
0.761 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272404 |
Tyr705 |
DPGSAAPyLKTKFIC |
Canis lupus familiaris |
MDCK Cell |
| pmid |
sentence |
| 16611743 |
In addition, SHP-2 dephosphorylates tyrosine-phosphorylated Stat1/3/5A (Ohtani et al., 2000; Wu et al., 2002; Chen et al., 2003), and downregulates Stat3-mediated biological actions (Ohtani et al., 2000).|Inhibition of collagen-induced Stat3 tyrosine-705 (Stat3-p-Tyr) |
|
| Publications: |
1 |
Organism: |
Canis Lupus Familiaris |
| Pathways: | Acute Myeloid Leukemia, KIT in AML, EGFR Signaling, FLT3-ITD signaling, Leptin Signaling |
| + |
PTPN4 | down-regulates activity
dephosphorylation
|
STAT3 |
0.257 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277057 |
Tyr705 |
DPGSAAPyLKTKFIC |
Homo sapiens |
|
| pmid |
sentence |
| 31025789 |
In terms of molecular mechanisms, we revealed that PTPN4 dephosphorylates pSTAT3 at the Tyr705 residue with a direct interaction, which might provide novel targets for the therapy of CRC.|Loss of PTPN4 Activates STAT3 to Promote the Tumor Growth in Rectal Cancer. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT3 | up-regulates quantity by expression 
transcriptional regulation
|
HAMP |
0.439 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255239 |
|
|
Homo sapiens |
HuH-7 Cell |
| pmid |
sentence |
| 18671304 |
HCV-induced ROS stabilized the expression of two negative hepcidin regulators, HIF1alpha and HIF2alpha, and its expression was decreased by a HDAC inhibitor or an anti-oxidant. HCV-induced ROS also caused hypoacetylation of histones and inhibited binding of two positive regulators, C/EBPalpha and STAT3, to the hepcidin promoter, whereas anti-oxidant treatment of cells recovered C/EBPalpha and STAT3 binding to the hepcidin promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CNTFR | up-regulates
|
STAT3 |
0.346 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-72774 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10582086 |
Clc/clf activates stat1 and stat3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
JAK3 | up-regulates
phosphorylation
|
STAT3 |
0.785 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256254 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30029643 |
Since Jak-STAT pathway primarily activated in IL-15-me- diated cell proliferation, we tested whether it is also participates in IL-15-mediated proliferation of FAPs. Interestingly, we found the expression of phospho-Jak3 and phospho-Tyk2, as well as their downstream, phospho- STAT3 and phospho-STAT5, was significantly upregulated |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT3 | up-regulates quantity by expression
transcriptional regulation
|
HSPA1A |
0.323 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255240 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19754877 |
Hsp105beta upregulates hsp70 gene expression through signal transducer and activator of transcription-3. Hsp105beta induces Hsp70 expression markedly through the STAT3 pathway in heat-shocked cells. This may represent the mechanism that connects the heat shock protein and STAT families for cell defense against deleterious stress. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DSCAM | up-regulates activity
binding
|
STAT3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264277 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 30745319 |
Our findings now further suggest that STAT3 and the adaptor protein SH2D2A interact with tyrosine‐containing motifs within the DSCAM/L1 ICDs. The SH2 domains of both STAT3 and SH2D2A are known to bind to phosphorylated tyrosine residues in the context of such motifs. Thus, the interactions between DSCAMs and SH2‐domain containing proteins seem to play a central and conserved role in Dscam signaling in the context of dynamic changes of tyrosine‐phosphorylation levels. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PK | up-regulates activity
phosphorylation
|
STAT3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268149 |
|
|
in vitro |
|
| pmid |
sentence |
| 22306293 |
PKM2 activates transcription of MEK5 by phosphorylating stat3 at Y705. In vitro phosphorylation assays show that PKM2 is a protein kinase using PEP as a phosphate donor |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270312 |
|
|
in vitro |
|
| pmid |
sentence |
| 22306293 |
PKM2 activates transcription of MEK5 by phosphorylating stat3 at Y705. In vitro phosphorylation assays show that PKM2 is a protein kinase using PEP as a phosphate donor |
|
| Publications: |
2 |
Organism: |
In Vitro |
| + |
STAT3 | up-regulates quantity by expression
transcriptional regulation
|
CCND1 |
0.78 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255411 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 18177723 |
We identified cyclin D1 as a STAT3 target gene product downregulated in satellite cells from IL-6-deficient muscle in vitro and in vivo. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253049 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16510571 |
Mutagenesis of STAT3 binding sites within the cyclin D1 promoter and chromatin immunoprecipitation studies showed an association between STAT3 and the transcriptional regulation of the human cyclin D1 gene. |
|
| Publications: |
2 |
Organism: |
Mus Musculus, Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| Pathways: | Acute Myeloid Leukemia |
| + |
SOCS3 | down-regulates 
|
STAT3 |
0.699 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249567 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 21628332 |
SOCS3 attenuates IL-6-induced STAT3 anti-inflammatory effects, as well as IL-4-induced insulin receptor substrate-2/PI3K-mediated gene expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | IL6 Signaling, Leptin Signaling |
| + |
STAT3 | up-regulates
|
Epithelial-mesenchymal_transition |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277690 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26738736 |
Collectively, the activation of IL-6/STAT3 pathway contributed to the PSCs-induced EMT i |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Fibroblast |
| + |
STAT3 | up-regulates quantity by expression
transcriptional regulation
|
IL1RN |
0.485 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254795 |
|
|
Homo sapiens |
Neutrophil, Monocyte |
| pmid |
sentence |
| 20032313 |
The interleukin 1 receptor antagonist (IL-1ra) is an important negative regulator of the inflammatory response, whose genetic deficiency has been recently shown to cause a severe autoinflammatory syndrome in humans. In this study we characterized the molecular mechanisms whereby interleukin 10 (IL-10) potentiates IL-1ra transcription in LPS-stimulated monocytes and neutrophils. our findings uncover a novel mechanism whereby IL-10-activated STAT3 modulates IL-1ra transcription in LPS-treated phagocytes by making IL-1ra promoter accessible to readily available nuclear NF-kappaB. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | SARS-CoV CYTOKINE STORM |
| + |
STAT3 | up-regulates quantity by expression
transcriptional regulation
|
SOCS3 |
0.699 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253583 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12565872 |
We also found that the wild type SOCS-3 promoter construct has significantly greater activity in non-small-cell lung cancer cell lines than in normal cells in accordance with STAT3 disregulation in these cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | IL6 Signaling, Leptin Signaling |
| + |
STAT3 | up-regulates
|
RORC |
0.626 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254303 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18454151 |
The inflammatory cytokines IL-6, IL-21 and IL-23 share signaling pathways by activating both STAT1 and STAT3, while IL-1beta is thought to activate the kinases IRAK1 and IRAK2 through recruitment of the adaptor MyD88. Thus, STAT3 is likely to be a common denominator in the induction of RORgammaT and IL-17 expression |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT3 | up-regulates
transcriptional regulation
|
IL10 |
0.783 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254515 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22378047 |
IL-10 activates STAT3-mediated expression of genes (Il10, Tgfb1, Mrc1) associated with an M2-like phenotype |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256234 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28713870 |
These data argue that, in TH2 cells, STAT3 is required for T cell IL-10 production, which in turn reinforces its own expression |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Macrophage polarization, Multiple sclerosis, SARS-CoV CYTOKINE STORM |
| + |
STAT3 | up-regulates quantity by expression
transcriptional regulation
|
GAP43 |
0.306 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266772 |
|
|
Rattus norvegicus |
Astrocyte |
| pmid |
sentence |
| 26865625 |
In this study, we demonstrated for the first time that growth-associated protein 43 (GAP43), a well known growth cone protein that promotes axonal regeneration, can be induced in rat brain astrocytes by the proinflammatory endotoxin lipopolysaccharide via both nuclear factor-κB and signal transducer and activator of transcription 3-mediated transcriptional activation. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
PIAS3 | down-regulates activity
binding
|
STAT3 |
0.72 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-238648 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9388184 |
PIAS3 blocked the DNA- binding activity of Stat3 and inhibited Stat3-mediated gene activation. Although Stat1 is also phosphorylated in response to IL-6, PIAS3 did not interact with Stat1 or affect its DNA-binding or transcriptional activity. The results indicate that PIAS3 is a specific inhibitor of Stat3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | IL6 Signaling |
| + |
ALK | up-regulates
binding
|
STAT3 |
0.452 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-122085 |
|
|
Homo sapiens |
Lymphoma Cell |
| pmid |
sentence |
| 14968112 |
Npm-alk has been shown to activate signal transducer and activator of transcription (stat) 3, a transcriptional regulator of cyclin d3.Proteins that interact with alk tyrosine kinase play important roles in mediating downstream cellular signals. Previously reported proteins in the alk signal pathway were identified including pi3-k, jak2, jak3, stat3, grb2, irs, and plcgamma1. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-139460 |
|
|
Homo sapiens |
Lymphoma Cell |
| pmid |
sentence |
| 16084951 |
Npm-alk has been shown to activate signal transducer and activator of transcription (stat) 3, a transcriptional regulator of cyclin d3.Proteins that interact with alk tyrosine kinase play important roles in mediating downstream cellular signals. Previously reported proteins in the alk signal pathway were identified including pi3-k, jak2, jak3, stat3, grb2, irs, and plcgamma1. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
IL1B | up-regulates activity
|
STAT3 |
0.572 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263820 |
|
|
Homo sapiens |
Helper T-lymphocyte |
| pmid |
sentence |
| 32454942 |
IL-1β, an inflammatory cytokine primarily expressed in activated macrophages, monocytes, and microglia, significantly contributes to MS development. IL-1β promotes differentiation of T cells into Th17 cells via the STAT3 pathway and thereby promotes and aggravates the inflammatory environment in the CNS |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Multiple sclerosis, SARS-CoV CYTOKINE STORM |
| + |
LEPR | up-regulates activity
binding, phosphorylation
|
STAT3 |
0.751 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263495 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11018044 |
LRb signaling is initiated by leptin binding to the extracellular domain of the LRb dimer, leading to Jak2 transphosphorylation and activation. Activated Jak2 mediates the tyrosine phosphorylation of Tyr985 and Tyr1138of LRb. These phosphotyrosine residues immediately function as binding sites (double-ended lines) for SHP-2 and STAT3, both of which quickly become tyrosine-phosphorylated by Jak2. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263492 |
|
|
Homo sapiens |
HT-1080 Cell |
| pmid |
sentence |
| 18718905 |
These observations indicate that leptin stimulates tyrosine phosphorylation of STAT3 via LEPRb but independent of JAK2. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Leptin Signaling |
| + |
SOCS3 | down-regulates activity
|
STAT3 |
0.699 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255330 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24600449 |
A main role of SOCS3 results from its binding to both the JAK kinase and the cytokine receptor, which results in the inhibition of STAT3 activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | IL6 Signaling, Leptin Signaling |
| + |
STAT3 | up-regulates quantity by expression
transcriptional regulation
|
SALL4 |
0.566 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255244 |
|
|
Homo sapiens |
MDA-MB-231 Cell |
| pmid |
sentence |
| 19151334 |
We further tested the functional relationship between STAT3 and SALL4 using MDA-MB-231, a breast cell line carrying constitutive SALL4 expression and STAT3 activity. Down-regulation of the STAT3 activity using a dominant-negative construct resulted in a significant decrease in the expression of SALL4. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HIC1 | down-regulates quantity by repression
binding
|
STAT3 |
0.375 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254246 |
|
|
Homo sapiens |
MDA-MB-231 Cell |
| pmid |
sentence |
| 24067369 |
HIC1 interacts with the DNA binding domain of STAT3 and suppresses the binding of STAT3 to its target gene promoters. HIC1 C-terminal domain binds to STAT3. HIC1 mutant defective in STAT3 interaction reduced its repressive effect on STAT3 DNA binding activity, the reporter activity and gene expression of the VEGF and c-Myc genes, and cell growth in MDA-MB 231 cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TYK2 | up-regulates
phosphorylation
|
STAT3 |
0.676 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-71781 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10542297 |
Stat3 activation requires kinase function of tyk2. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256255 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30029643 |
Since Jak-STAT pathway primarily activated in IL-15-me- diated cell proliferation, we tested whether it is also participates in IL-15-mediated proliferation of FAPs. Interestingly, we found the expression of phospho-Jak3 and phospho-Tyk2, as well as their downstream, phospho- STAT3 and phospho-STAT5, was significantly upregulated |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | EBV infection |
| + |
EML4-ALK | up-regulates activity
phosphorylation
|
STAT3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259203 |
|
|
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 21415216 |
We also found that phosphorylation of both the mitogen-activated proteinkinase (MAPK) ERK and STAT3 was markedly increased inthe cells expressing either variant of EML4-ALK[.]. Oncogenic EML4-ALK tyrosine kinase activates ERKand STAT3 signaling pathways |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
STAT3 | up-regulates
|
T_cell_activation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263821 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32454942 |
IL-1β, an inflammatory cytokine primarily expressed in activated macrophages, monocytes, and microglia, significantly contributes to MS development. IL-1β promotes differentiation of T cells into Th17 cells via the STAT3 pathway and thereby promotes and aggravates the inflammatory environment in the CNS |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EBV infection, Multiple sclerosis, SARS-CoV CYTOKINE STORM |
| + |
EGFR | up-regulates activity
phosphorylation
|
STAT3 |
0.876 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235692 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 22693070 |
The transcription factors stat1, stat3, and stat5 are directly phosphorylated by erbb-1, subsequent to which they dimerize through phosphotyrosine-sh2 domain interactions and translocate to the nucleus to activate gene trascription critical for proliferation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-121965 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14967450 |
The transcription factors stat1, stat3, and stat5 are directly phosphorylated by erbb-1, subsequent to which they dimerize through phosphotyrosine-sh2 domain interactions and translocate to the nucleus to activate gene trascription critical for proliferation. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, EGFR Signaling, Pancreatic ductal adenocarcinoma (PDA) |
| + |
STAT3 | up-regulates quantity by expression
transcriptional regulation
|
SOCS3 |
0.699 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253050 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11159537 |
STAT3-mediated constitutive expression of SOCS-3 in cutaneous T-cell lymphoma. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | IL6 Signaling, Leptin Signaling |
| + |
PPARG | down-regulates
|
STAT3 |
0.386 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249556 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 17681149 |
Transcriptional repression of inflammatory response genes occurs by negative interference of PPARg with the nuclear factor kB (NF-kB), signal transducer and activator of transcription (STAT), and activating protein 1 (AP-1) signaling pathways |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Leptin Signaling, Macrophage polarization |
| + |
STAT3 | up-regulates quantity by expression
transcriptional regulation
|
POMC |
0.625 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263497 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 19049975 |
We show that phospho-STAT3 activates POMC promoter in response to leptin signaling through a mechanism that requires an SP1-binding site in the POMC promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Leptin Signaling |
| + |
STAT3 | up-regulates
transcriptional regulation
|
TGFB1 |
0.612 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254517 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 22378047 |
IL-10 activates STAT3-mediated expression of genes (Il10, Tgfb1, Mrc1) associated with an M2-like phenotype |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EBV infection |
| + |
STAT3 | up-regulates quantity by expression
transcriptional regulation
|
CD274 |
0.479 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259188 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27141364 |
STAT3 and HIF-1α cooperatively enhance PD-L1 expression in EML4-ALK-translocated pADC cells under hypoxia.The protein-DNA binding assay revealed that pSTAT3 was bound to the PD-L1 promoter region in H23 cells transfected with EML4-ALK. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT3 | up-regulates
|
Proliferation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255632 |
|
|
Homo sapiens |
Satellite Cell |
| pmid |
sentence |
| 18177723 |
Altogether, these data demonstrate that IL-6 loss results in deficient STAT3 signaling in activated satellite cells, leading to their reduced proliferation and myogenic progression, and highlight the major role played by the IL-6/STAT3 axis in controlling these processes during compensatory hypertrophy. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-245048 |
|
|
Homo sapiens |
Satellite Cell |
| pmid |
sentence |
| 25194572 |
STAT3 signaling controls satellite cell expansion and skeletal muscle repair |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256256 |
|
|
Homo sapiens |
Mesenchymal Stem Cell |
| pmid |
sentence |
| 30029643 |
In summary, our results indicate IL-15 can stimulate the proliferation of FAPs through Jak-STAT pathway. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| Pathways: | Acute Myeloid Leukemia, KIT in AML, EGFR Signaling, EBV infection, FLT3-ITD signaling, IL6 Signaling, Leptin Signaling, Pancreatic ductal adenocarcinoma (PDA), Rhabdomyosarcoma |
| + |
PIAS3 | down-regulates
sumoylation
|
STAT3 |
0.72 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-124723 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15138572 |
Stat3 mediated signaling pathways can be inhibited by pias3 (protein inhibitor of activated stat3), which was recently found to regulate protein stability and function by its sumo (small-ubiquitin like modifiers) ligase activity in promoting sumoylation of important nuclear proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | IL6 Signaling |
| + |
DUSP3 | down-regulates activity
dephosphorylation
|
STAT3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277070 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32475380 |
DUSP3 interacted with the C-terminal domain of STAT3 and dephosphorylated p-Y705 of STAT3.|In summary, DUSP3 downregulated the transcriptional activity of STAT3 via dephosphorylation at Y705 and also suppressed the migratory activity of cancer cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT3 | up-regulates quantity by expression
transcriptional regulation
|
MYOD1 |
0.536 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255416 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 25194572 |
Here we show that IL-6-activated Stat3 signaling regulates satellite cell behavior, promoting myogenic lineage progression through myogenic differentiation 1 (Myod1) regulation. IL-6 stimulation promoted an increase in the mRNA levels of both Stat3 and Myod1. Stat3 mediated this effect, as IL-6–dependent Myod1 upregulation was impaired after infection with the shStat3 lentivirus. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Rhabdomyosarcoma |
| + |
IL20RA | up-regulates
|
STAT3 |
0.565 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-86269 |
|
|
Homo sapiens |
T-lymphocyte, Monocyte |
| pmid |
sentence |
| 12941475 |
Il-20 induces cheratin proliferation and stat-3 signal transduction pathway |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT3 | up-regulates quantity by expression
transcriptional regulation
|
STAT1 |
0.596 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263650 |
|
|
Homo sapiens |
Breast Cancer Cell Line |
| pmid |
sentence |
| 22693070 |
In summary, we report in this study that STAT1 expression is upregulated by nuclear EGFR, EGFRvIII and HER2, and that STAT3 synergizes with the three receptors to further enhance STAT1 expression. These novel findings establish a novel link between the mitogenic ErbB signaling pathway and the inflammatory pathway mediated by STAT1. The oncogenic transcription factor STAT3 binds to the STAT1 promoter and synergizes with nuclear EGFR to significantly enhance STAT1 gene expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EGFR Signaling, EBV infection, SARS-CoV CYTOKINE STORM |
| + |
MFGE8 | up-regulates activity
|
STAT3 |
0.28 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260654 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21901532 |
In an attempt to clarify the direct anti-inflammatory role of MFG-E8, we revealed a distinct signaling pathway where MFG-E8 activates suppressor of cytokine signaling (SOCS) 3 gene expression via STAT3 mediated pathway, which in turn served as a negative regulator for LPS induced TLR4 signaling by targeting NF-κB p65 component, thereby attenuating the down-stream signaling for TNF-α production |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL21R | up-regulates
|
STAT3 |
0.594 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-133379 |
|
|
Homo sapiens |
Monocyte |
| pmid |
sentence |
| 15667561 |
Interleukin 24 (il-24) is a new member of the il-10 family of cytokines and it signals through two heterodimeric receptors: il-20r1/il-20r2 and il-22r1/il-20r2. Upon binding to its receptors, il-24 induces rapid activation of stat-1 and stat-3 transcription factors, |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Lung, Skin |
| + |
OR5B21 | up-regulates activity
|
STAT3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272503 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34917897 |
Since NF-κB activation is an important characteristic of EMT and cancer metastasis, we evaluated the effect of OR5B21 on this pathway as well as two transcription factors known to co-operate with NF-κB as synergistic initiators and master regulators of EMT, the signal transducer and activator of transcription 3 (STAT3) and the CCAAT/enhancer binding protein b (C/EBPβ) | Of importance, OR5B21 knockdown inhibited phosphorylation of STAT3 and reversed the expression of MMP2, MMP9, and Snail, which coincided with a decrease in both C/EBPβ levels and activation of NF-κB, whereas overexpression of OR5B21 had the opposite effect, endorsing the role of C/EBPβ/STAT3 in OR5B21-induced metastasis | Together, these data suggest that OR5B21 promotes breast cancer metastasis to different tissues by activating EMT through the STAT3/NF-κB/C/EBPβ signaling axis, revealing OR5B21 as a potential target for breast cancer therapy |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT3 | up-regulates quantity by expression
transcriptional regulation
|
CEBPD |
0.596 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255334 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 25787076 |
P-Stat3 stimulates C/EBPδ expression and activity, which increases myostatin and MAFbx/Atrogin-1 and MuRF-1. Both pathways result in protein losses in muscle. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255333 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 24011072 |
To assess whether Stat3 affects C/EBPδ expression, we co-transfected C2C12 myoblasts with a plasmid expressing a C/EBPδpromoter-driven luciferase plus a lentivirus expressing the constitutively active Stat3C-GFP. Overexpression of Stat3C increased C/EBPδpromoter activity compared to that in lentivirus expressing GFP control |
|
| Publications: |
2 |
Organism: |
Mus Musculus |
| + |
TRiC | up-regulates quantity by stabilization
binding
|
STAT3 |
0.395 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272870 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 36185250 |
Mammalian cells contain an evolutionarily conserved type II chaperonin called chaperonin containing tailless complex polypeptide 1 (CCT) or tailless complex polypeptide 1 ring complex (TRiC). The CCT complex is composed of eight subunits [CCT1-8 (yeast) or CCTα-θ (mammals)] and folds substrates needed for cell invasion and proliferation, such as actin, tubulin, and cell division cycle protein 20 homolog (cdc20), as well as oncoproteins like signal transducer and activator of transcription 3 (STAT3), Kirsten rat sarcoma viral oncogene homolog (KRAS), and Myelocytomatosis (MYC). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT3 | up-regulates quantity by expression
transcriptional regulation
|
HSPA1B |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255241 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19754877 |
Hsp105beta upregulates hsp70 gene expression through signal transducer and activator of transcription-3. Hsp105beta induces Hsp70 expression markedly through the STAT3 pathway in heat-shocked cells. This may represent the mechanism that connects the heat shock protein and STAT families for cell defense against deleterious stress. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPN6 | down-regulates
dephosphorylation
|
STAT3 |
0.47 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178699 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18508557 |
Stat3 may also be a substrate of shp1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia |
| + |
5,15-Diphenyl-21H,23H-porphine | down-regulates activity
chemical inhibition
|
STAT3 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-238549 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26260587 |
15-DPP is an effective STAT3 inhibitor and blocks IL10-mediated signalling in macrophages leading to altered regulation of CNV |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DSCAML1 | up-regulates activity
binding
|
STAT3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264278 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 30745319 |
Our findings now further suggest that STAT3 and the adaptor protein SH2D2A interact with tyrosine‐containing motifs within the DSCAM/L1 ICDs. The SH2 domains of both STAT3 and SH2D2A are known to bind to phosphorylated tyrosine residues in the context of such motifs. Thus, the interactions between DSCAMs and SH2‐domain containing proteins seem to play a central and conserved role in Dscam signaling in the context of dynamic changes of tyrosine‐phosphorylation levels. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT3 | form complex 
binding
|
SMAD2/STAT3/EP300 |
0.567 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255024 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26194464 |
Thus, pSmad2L (Ser255) forms complex with p300 and STAT3 to bind to the proximal promoter of the Rorc and Il17a genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMAD3/PIAS3 | down-regulates
|
STAT3 |
0.632 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255036 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26194464 |
In summary, the TGF-b/IL-6/TCR-pERK-Smad2L (Ser255) axis is the positive regulator, whereas unphosphorylated Smad3C-PIAS3 complex is the negative regulator of STAT3-induced transcriptional processes for TH17 differentiation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL6 | up-regulates activity
|
STAT3 |
0.748 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255415 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 23869758 |
IL-6 induced dose-dependent increase in satellite cell proliferation by activating the JAK2/STAT3/cyclin D1 pathway.Treatment with 1 ng/ml IL-6 for 3 h significantly increased p-STAT3+/MyoD+ cell numbers by 44% compared to control media only . |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| Tissue: |
Skeletal Muscle |
| Pathways: | IL6 Signaling, Multiple sclerosis, SARS-CoV CYTOKINE STORM |
| + |
STAT3 | up-regulates quantity by expression
transcriptional regulation
|
KRT17 |
0.262 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255234 |
|
|
Homo sapiens |
Keratinocyte |
| pmid |
sentence |
| 21796151 |
IL-17A upregulates keratin 17 expression in keratinocytes through STAT1- and STAT3-dependent mechanisms. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT3 | up-regulates quantity by expression
transcriptional regulation
|
FBXO32 |
0.286 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255331 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22669242 |
Thus we infected C2C12 myofibers with a recombinant adenovirus expressing a mutant, constitutively activated STAT3 (cSTAT3) known to possess increased DNA binding/transcriptional activity. Consistent with wasting, atrogin-1 expression was also markedly increased (Fig. 3A). Thus STAT3 activation is by itself sufficient to induce muscle fiber wasting in cell culture. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
STAT3 | up-regulates quantity by expression
transcriptional regulation
|
PLK1 |
0.312 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271690 |
|
|
|
|
| pmid |
sentence |
| 22108192 |
Stat3 directly activated transcription of PLK1 in esophageal cancer cells and mouse embryonic fibroblast cell NIH3T3. |
|
| Publications: |
1 |
| + |
STAT3 | up-regulates quantity by expression
transcriptional regulation
|
VEGFA |
0.779 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259456 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12545153 |
Stat3 directly regulated the promoter of the VEGF gene. Blockade of activated Stat3 by ectopic expression of dominant-negative Stat3 significantly inhibited VEGF expression, and the growth and metastasis of human pancreatic cancer cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Pancreatic ductal adenocarcinoma (PDA) |
| + |
STAT3 | up-regulates
|
Fibrosis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256257 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30029643 |
Taken together, our data show IL-15 can enhance the collagen deposition in vivo after muscle damage and this process can be prevented by blocking Jak-STAT pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL22RA1 | up-regulates
|
STAT3 |
0.638 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-90162 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12087100 |
Il-22 also induced serine phosphorylation of stat3 on ser(727). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT3 | up-regulates
|
M2_polarization |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249547 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10347215 |
The data presented this far show that the JAK-STAT signaling pathway and specifically Stat3 and Jak1 are required for induction of IL-10-dependent anti-inflammatory and developmental responses in macrophages. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Macrophage polarization, Multiple sclerosis |
| + |
STC2 | up-regulates
|
STAT3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260406 |
|
|
Mus musculus |
COS-7 Cell |
| pmid |
sentence |
| 29207625 |
STC2 activates STAT3 signaling pathway in the hypothalamus and GT1-7 cells |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PTPN14 | down-regulates activity
dephosphorylation
|
STAT3 |
0.275 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277088 |
|
|
Chlorocebus aethiops |
|
| pmid |
sentence |
| 35259601 |
Moreover, dephosphorylation of STAT3 by PTPN14 might occur in the cytoplasm but not in nucleus.|The tyrosine phosphatase PTPN14 inhibits the activation of STAT3 in PEDV infected Vero cells. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
DUSP22 | down-regulates activity
dephosphorylation
|
STAT3 |
0.366 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277149 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16636663 |
IL-6 and LIF-induced LMW-DSP2 expression in murine testicular or hepatoma cell lines, while LMW-DSP2 overexpression in 293T cells suppressed IL-6-induced phosphorylation and activation of STAT3.|These results strongly suggest that LMW-DSP2 acts as a negative regulator of the IL-6/LIF/STAT3-mediated signaling pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT3 | up-regulates quantity by expression
transcriptional regulation
|
CASP3 |
0.476 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255335 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 25787076 |
We determined that Stat3 activation increases caspase-3 expression in C2C12 cells. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
STAT3 | form complex
binding
|
SP1/STAT3 |
0.467 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-187793 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19723038 |
Sp1 and stat3 seem to synergistically augment renalase transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT3 | down-regulates
|
FOXP3 |
0.592 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254364 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18156621 |
Our results demonstrate that IL-27 inhibits the acquisition of the Treg phenotype at the level of Foxp3. The inhibitory effect of IL-27 on Treg generation was at least partially signal transducer and activator of transcription 3 (STAT3) dependent as examined by targeted STAT3 protein inhibition using small interfering RNA (siRNA) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254304 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18156621 |
Our results demonstrate that IL-27 inhibits the acquisition of the Treg phenotype at the level of Foxp3. The inhibitory effect of IL-27 on Treg generation was at least partially signal transducer and activator of transcription 3 (STAT3) dependent as examined by targeted STAT3 protein inhibition using small interfering RNA (siRNA) |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
STAT3 | up-regulates
|
Cell_growth |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252090 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 11426647 |
Constitutive activation of Stat3 signaling is accompanied by upregulation of cyclin D1, c-Myc, and Bcl-x, changes consistent with subversion of normal cellular growth and survival control mechanisms. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | EGFR Signaling, IL6 Signaling |
| + |
IL20RB | up-regulates
|
STAT3 |
0.49 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-86305 |
|
|
Homo sapiens |
T-lymphocyte, Monocyte |
| pmid |
sentence |
| 12941475 |
Il-20 induces cheratin proliferation and stat-3 signal transduction pathway |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT3 | up-regulates quantity by expression
transcriptional regulation
|
S100A9 |
0.381 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261931 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 18809714 |
Accumulation of myeloid-derived suppressor cells (MDSCs) associated with inhibition of dendritic cell (DC) differentiation is one of the major immunological abnormalities in cancer and leads to suppression of antitumor immune responses. The molecular mechanism of this phenomenon remains unclear. We report here that STAT3-inducible up-regulation of the myeloid-related protein S100A9 enhances MDSC production in cancer. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | FLT3-ITD signaling |
| + |
STAT3 | form complex
binding
|
STAT1/STAT3 |
0.596 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235664 |
|
|
Mus musculus |
Keratinocyte |
| pmid |
sentence |
| 15284024 |
Stimulation of EGFR induces Tyr701 phosphorylation of STAT1 and initiates complex formation of STAT1 and STAT3 with JAK1 and JAK2. Thereafter, the STATs translocate to the nucleus within 15 min. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
STAT3 | up-regulates quantity by expression
transcriptional regulation
|
HGF |
0.608 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251742 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 11278729 |
Coexpression of activated c-Src and Stat3 synergistically induced strong HGF promoter activity in SP1 cells |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Rhabdomyosarcoma |
| + |
S3I-201 | down-regulates
chemical inhibition
|
STAT3 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-194847 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT3 | up-regulates quantity by expression
|
MYC |
0.744 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255413 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21408055 |
Additionally, cMyc, a STAT3 downstream gene, was significantly up-regulated in SCs at T24 versus PRE [...]An increase in the number of cMyc+ SCs indicated that human SCs were induced to proliferate under the control of STAT3 signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| Pathways: | Acute Myeloid Leukemia, KIT in AML, EGFR Signaling, FLT3-ITD signaling, Rhabdomyosarcoma |
| + |
FOXO1 | down-regulates activity
binding
|
STAT3 |
0.58 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263496 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 25510553 |
FoxO1, which is up-regulated during early stages of diet-induced leptin resistance, directly interacts with STAT3 and prevents STAT3 from binding to specificity protein 1 (SP1)-pro-opiomelanocortin (POMC) promoter complex, and thereby inhibits STAT3-mediated regulation of POMC transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Leptin Signaling, Rhabdomyosarcoma |
| + |
STAT3 | up-regulates quantity by expression
transcriptional regulation
|
BIRC5 |
0.61 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254762 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26512963 |
DAB2IP could interact with the signal transducer and activator of transcription 3 (STAT3) via its unique PR domain and suppress STAT3 phosphorylation and transactivation, leading to the inhibition of survivin expression in PCa cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT3 | up-regulates quantity by expression
transcriptional regulation
|
CD46 |
0.271 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255238 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17699108 |
The CD46 promoter contains two binding sites for activated STAT3 and mutations introduced into the major site abolished STAT3 binding. Chromatin immunoprecipitation confirms binding of STAT3 to the CD46 promoter. CD46 promoter activity is induced by activation of STAT3 and blocked by a dominant-negative form of STAT3 in luciferase reporter assays. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DAB2IP | down-regulates activity
binding
|
STAT3 |
0.354 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254761 |
|
|
Homo sapiens |
Prostate Cancer Cell Line |
| pmid |
sentence |
| 26512963 |
DAB2IP could interact with the signal transducer and activator of transcription 3 (STAT3) via its unique PR domain and suppress STAT3 phosphorylation and transactivation, leading to the inhibition of survivin expression in PCa cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
STAT3
- 
- 