Summary

Name STAT3
Full Name Signal transducer and activator of transcription 3
Synonyms Acute-phase response factor | APRF
Primary ID P40763
Links - -
Type protein
Relations 126
Pathways Acute Myeloid Leukemia, KIT in AML, EGFR Signaling, EBV infection, FAP: IL15, FLT3-ITD signaling, IL6 Signaling, Leptin Signaling, Macrophage polarization, Macrophage: IL10, Macrophage: IL6, Macrophage: Polarization and myogenesis, Macrophage: TGF beta transcriptional regulation, Multiple sclerosis, Myoblast: IL6 and hypertrophy, Myofiber: IL6 and atrophy, Pancreatic ductal adenocarcinoma (PDA), Rhabdomyosarcoma, SARS-CoV CYTOKINE STORM, Satellite: IL6, T-Lymphocyte: IL10, T-Lymphocyte: IL6, T-Lymphocyte: TGF beta
Inhibitors 5,15-Diphenyl-21H,23H-porphine; S3I-201
Function Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (PubMed:10688651, PubMed:12359225, PubMed:12873986, PubMed:15194700, PubMed:17344214, PubMed:18242580, PubMed:23084476). Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:17344214). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:12873986). Upon activation of IL6ST/gp130 signaling by interleukin-6 (IL6), binds to the IL6-responsive elements identified in the promoters of various acute-phase protein genes (PubMed:12359225). Activated by IL31 through IL31RA (PubMed:15194700). Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg)

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation STAT3 0.414
Publications: 1 Organism: Homo Sapiens
Tissue: Skin
+ up-regulates img/direct-activation.png phosphorylation STAT3 0.571
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation STAT3 0.298
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR Signaling, EBV infection, Macrophage polarization
+ up-regulates img/direct-activation.png phosphorylation STAT3 0.606
Publications: 2 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ up-regulates img/direct-activation.png phosphorylation STAT3 0.418
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Myotube, Brain
+ down-regulates activity img/direct_inhibition.png dephosphorylation STAT3 0.334
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation STAT3 0.574
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation STAT3 0.591
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, EGFR Signaling, Macrophage polarization
+ up-regulates img/direct-activation.png phosphorylation STAT3 0.355
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation STAT3 0.343
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation STAT3 0.499
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation STAT3 0.738
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, KIT in AML, FLT3-ITD signaling, Leptin Signaling, Pancreatic ductal adenocarcinoma (PDA)
+ up-regulates img/direct-activation.png phosphorylation STAT3 0.709
Publications: 4 Organism: Homo Sapiens
Tissue: Kidney
+ up-regulates img/direct-activation.png phosphorylation STAT3 0.395
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation STAT3 0.709
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation STAT3 0.782
Publications: 2 Organism: Homo Sapiens, Mus Musculus
Pathways:EGFR Signaling, IL6 Signaling, Rhabdomyosarcoma
+ up-regulates img/direct-activation.png phosphorylation STAT3 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation, binding STAT3 0.794
Publications: 4 Organism: Homo Sapiens, Mus Musculus
Pathways:EBV infection, IL6 Signaling, Multiple sclerosis, SARS-CoV CYTOKINE STORM
+ up-regulates activity img/direct-activation.png dephosphorylation STAT3 0.262
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation STAT3 0.813
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, KIT in AML, EGFR Signaling, EBV infection, Leptin Signaling, Macrophage polarization
+ up-regulates activity img/direct-activation.png phosphorylation STAT3 0.598
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation STAT3 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation STAT3 0.761
Publications: 1 Organism: Canis Lupus Familiaris
Pathways:Acute Myeloid Leukemia, KIT in AML, EGFR Signaling, FLT3-ITD signaling, Leptin Signaling
+ down-regulates activity img/direct_inhibition.png dephosphorylation STAT3 0.725
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation STAT3 0.612
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation STAT3 0.574
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation STAT3 0.574
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation STAT3 0.725
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation STAT3 0.537
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation STAT3 0.414
Publications: 1 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma
+ down-regulates activity img/direct_inhibition.png dephosphorylation STAT3 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation STAT3 0.463
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ down-regulates img/direct_inhibition.png dephosphorylation STAT3 0.537
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates activity img/direct-activation.png phosphorylation STAT3 0.463
Publications: 1 Organism: In Vitro
Pathways:FLT3-ITD signaling
+ down-regulates activity img/direct_inhibition.png dephosphorylation STAT3 0.535
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation KRT17 0.264
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation STAT3 0.876
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, EGFR Signaling, Pancreatic ductal adenocarcinoma (PDA)
+ up-regulates img/indirect-activation.png transcriptional regulation IL10 0.784
Publications: 2 Organism: Homo Sapiens
Pathways:Macrophage polarization, Multiple sclerosis, SARS-CoV CYTOKINE STORM
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation POMC 0.625
Publications: 1 Organism: Homo Sapiens
Pathways:Leptin Signaling
+ up-regulates activity img/indirect-activation.png STAT3 0.572
Publications: 1 Organism: Homo Sapiens
Pathways:Multiple sclerosis, SARS-CoV CYTOKINE STORM
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HSPA1B 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png M2_polarization 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:Macrophage polarization, Multiple sclerosis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CEBPD 0.595
Publications: 2 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HAMP 0.444
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Proliferation 0.7
Publications: 3 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:Acute Myeloid Leukemia, KIT in AML, EGFR Signaling, EBV infection, FLT3-ITD signaling, IL6 Signaling, Leptin Signaling, Pancreatic ductal adenocarcinoma (PDA), Rhabdomyosarcoma
+ up-regulates img/indirect-activation.png T_cell_activation 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:EBV infection, Multiple sclerosis, SARS-CoV CYTOKINE STORM
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation SOCS3 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:IL6 Signaling, Leptin Signaling
+ up-regulates img/indirect-activation.png RORC 0.626
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation STAT3 0.677
Publications: 2 Organism: Homo Sapiens
Pathways:EBV infection
+ up-regulates activity img/direct-activation.png phosphorylation STAT3 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation PLK1 0.314
Publications: 1
+ up-regulates activity img/direct-activation.png binding STAT3 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png STAT3 0.282
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation STAT3 0.786
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CD46 0.273
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation VEGFA 0.779
Publications: 1 Organism: Homo Sapiens
Pathways:Pancreatic ductal adenocarcinoma (PDA)
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYOD1 0.54
Publications: 1 Organism: Mus Musculus
Pathways:Rhabdomyosarcoma
+ form complex img/form-complex.png binding SP1/STAT3 0.47
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding SMAD2/STAT3/EP300 0.569
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation STAT1 0.59
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR Signaling, EBV infection, SARS-CoV CYTOKINE STORM
+ up-regulates activity img/direct-activation.png binding, phosphorylation STAT3 0.751
Publications: 2 Organism: Homo Sapiens
Pathways:Leptin Signaling
+ down-regulates activity img/direct_inhibition.png chemical inhibition STAT3 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png STAT3 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:IL6 Signaling, Leptin Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL1RN 0.483
Publications: 1 Organism: Homo Sapiens
Pathways:SARS-CoV CYTOKINE STORM
+ up-regulates activity img/indirect-activation.png STAT3 0.749
Publications: 1 Organism: Rattus Norvegicus
Tissue: Skeletal Muscle
Pathways:IL6 Signaling, Multiple sclerosis, SARS-CoV CYTOKINE STORM
+ up-regulates img/indirect-activation.png STAT3 0.488
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png binding STAT3 0.39
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding STAT3 0.456
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation STAT3 0.475
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ down-regulates activity img/direct_inhibition.png binding STAT3 0.58
Publications: 1 Organism: Homo Sapiens
Pathways:Leptin Signaling, Rhabdomyosarcoma
+ down-regulates img/indirect_inhibition.png FOXP3 0.597
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CASP3 0.482
Publications: 1 Organism: Mus Musculus
+ form complex img/form-complex.png binding STAT1/STAT3 0.59
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png STAT3 0.634
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png STAT3 0.564
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png STAT3 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png transcriptional regulation TGFB1 0.61
Publications: 1 Organism: Homo Sapiens
Pathways:EBV infection
+ down-regulates activity img/direct_inhibition.png binding STAT3 0.719
Publications: 1 Organism: Homo Sapiens
Pathways:IL6 Signaling
+ down-regulates img/direct_inhibition.png chemical inhibition STAT3 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation HGF 0.608
Publications: 1 Organism: Mus Musculus
Pathways:Rhabdomyosarcoma
+ up-regulates img/indirect-activation.png STAT3 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation STAT3 0.2
Publications: 2 Organism: In Vitro
+ up-regulates img/indirect-activation.png STAT3 0.594
Publications: 1 Organism: Homo Sapiens
Tissue: Lung, Skin
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CCND1 0.781
Publications: 2 Organism: Mus Musculus, Homo Sapiens
Tissue: Skeletal Muscle
Pathways:Acute Myeloid Leukemia
+ down-regulates quantity by repression img/direct_inhibition.png binding STAT3 0.375
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HSPA1A 0.325
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BIRC5 0.607
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CD274 0.485
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FBXO32 0.288
Publications: 1 Organism: Mus Musculus
+ up-regulates img/indirect-activation.png STAT3 0.639
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation S100A9 0.382
Publications: 1 Organism: Mus Musculus
Pathways:FLT3-ITD signaling
+ up-regulates img/indirect-activation.png STAT3 0.35
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding STAT3 0.358
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png STAT3 0.39
Publications: 1 Organism: Homo Sapiens
Pathways:Leptin Signaling, Macrophage polarization
+ up-regulates quantity by expression img/indirect-activation.png MYC 0.745
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:Acute Myeloid Leukemia, KIT in AML, EGFR Signaling, FLT3-ITD signaling, Rhabdomyosarcoma
+ down-regulates img/indirect_inhibition.png STAT3 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:IL6 Signaling, Leptin Signaling
+ up-regulates activity img/direct-activation.png binding STAT3 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Fibrosis 0.7
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png sumoylation STAT3 0.719
Publications: 1 Organism: Homo Sapiens
Pathways:IL6 Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SOCS3 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:IL6 Signaling, Leptin Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SALL4 0.565
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation GAP43 0.309
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates img/indirect-activation.png Cell_growth 0.7
Publications: 1 Organism: Mus Musculus
Pathways:EGFR Signaling, IL6 Signaling