Summary

Name STAT3
Full Name Signal transducer and activator of transcription 3
Synonyms Acute-phase response factor | APRF
Primary ID P40763
Links - -
Type protein
Relations 103
Pathways EGFR, Macrophage polarization, IL6 , Rhabdomyosarcoma, KIT in AML
Inhibitors 5,15-Diphenyl-21H,23H-porphine; S3I-201
Function Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (PubMed:10688651, PubMed:12359225, PubMed:12873986, PubMed:15194700, PubMed:17344214, PubMed:18242580, PubMed:23084476). Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:17344214). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:12873986). Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes (PubMed:12359225). Activated by IL31 through IL31RA (PubMed:15194700). Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg)

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation STAT3 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation STAT3 0.22
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Myotube, Brain
+ up-regulates img/direct-activation.png phosphorylation STAT3 0.28
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation STAT3 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR, Macrophage polarization
+ up-regulates img/direct-activation.png phosphorylation STAT3 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Skin
+ up-regulates img/direct-activation.png phosphorylation STAT3 0.2
Publications: 2 Organism: Homo Sapiens
Pathways:KIT in AML
+ up-regulates activity img/direct-activation.png phosphorylation STAT3 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR, Macrophage polarization
+ up-regulates img/direct-activation.png phosphorylation STAT3 0.2
Publications: 4 Organism: Homo Sapiens
Tissue: Kidney
+ up-regulates img/direct-activation.png phosphorylation STAT3 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation STAT3 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation STAT3 0.4
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation STAT3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation STAT3 0.36
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation STAT3 0.35
Publications: 1 Organism: Homo Sapiens
Tissue: Skin
+ up-regulates activity img/direct-activation.png phosphorylation STAT3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation STAT3 0.14
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png dephosphorylation STAT3 0.14
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation STAT3 0.38
Publications: 2 Organism: Homo Sapiens
Pathways:KIT in AML, Macrophage polarization
+ up-regulates activity img/direct-activation.png phosphorylation STAT3 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma
+ up-regulates activity img/direct-activation.png phosphorylation STAT3 0.42
Publications: 2 Organism: Homo Sapiens, Mus Musculus
Pathways:EGFR, IL6 , Rhabdomyosarcoma
+ down-regulates img/direct_inhibition.png dephosphorylation STAT3 0.4
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation STAT3 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates img/direct_inhibition.png dephosphorylation STAT3 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation STAT3 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation STAT3 0.4
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation, binding STAT3 0.56
Publications: 4 Organism: Mus Musculus, Homo Sapiens
Pathways:IL6
+ down-regulates activity img/direct_inhibition.png dephosphorylation STAT3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation STAT3 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation STAT3 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation STAT3 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding STAT3 0.53
Publications: 2 Organism: Homo Sapiens
Pathways:IL6
+ up-regulates img/direct-activation.png phosphorylation STAT3 0.34
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding SP1/STAT3 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png FOXP3 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding STAT3 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Cell Growth 0.22
Publications: 1 Organism: Mus Musculus
Pathways:EGFR, IL6
+ up-regulates img/indirect-activation.png RORC 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png STAT3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png transcriptional regulation IL10 0.28
Publications: 2 Organism: Homo Sapiens
Pathways:Macrophage polarization
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CASP3 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CEBPD 0.2
Publications: 2 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FBXO32 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CCND1 0.37
Publications: 2 Organism: Homo Sapiens, Mus Musculus
Tissue: Skeletal Muscle
+ up-regulates quantity by expression img/indirect-activation.png transcriptional activation SOCS3 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png STAT3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HSPA1B 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png STAT3 0.35
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Fibrosis 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation KRT17 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HAMP 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SALL4 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Proliferation 0.62
Publications: 3 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:KIT in AML, EGFR, IL6 , Rhabdomyosarcoma
+ down-regulates activity img/direct_inhibition.png binding STAT3 0.53
Publications: 1 Organism: Homo Sapiens
Pathways:IL6
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation SOCS3 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation STAT3 0.48
Publications: 2 Organism: Homo Sapiens
Pathways:EGFR
+ down-regulates img/indirect_inhibition.png STAT3 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:Macrophage polarization
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYOD1 0.14
Publications: 1 Organism: Mus Musculus
Pathways:Rhabdomyosarcoma
+ down-regulates quantity by repression img/direct_inhibition.png binding STAT3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png transcriptional regulation TGFB1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation STAT3 0.43
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL1RN 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png STAT3 0.34
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding SMAD2/STAT3/EP300 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional activation CD274 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png MYC 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:KIT in AML, EGFR, Rhabdomyosarcoma
+ form complex img/form-complex.png binding STAT1/STAT3 0.14
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png chemical inhibition STAT3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png M2 polarization 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:Macrophage polarization
+ up-regulates activity img/direct-activation.png phosphorylation STAT3 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/indirect-activation.png STAT3 0.22
Publications: 1 Organism: Rattus Norvegicus
Tissue: Skeletal Muscle
Pathways:IL6
+ up-regulates img/indirect-activation.png STAT3 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Lung, Skin
+ down-regulates activity img/direct_inhibition.png binding STAT3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png STAT3 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional activation VEGFA 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional activation BIRC5 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation HGF 0.14
Publications: 1 Organism: Mus Musculus
Pathways:Rhabdomyosarcoma
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CD46 0.14
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding JAK1/STAT1/STAT3 0.28
Publications: 1 Organism: Mus Musculus
Pathways:EGFR
+ down-regulates img/direct_inhibition.png chemical inhibition STAT3 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png STAT3 0.34
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HSPA1A 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png STAT3 0.34
Publications: 1 Organism: Homo Sapiens