| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| FES | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | phosphorylation up-regulates activity | 15003822 | SIGNOR-278937 |
| PTPN1 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | dephosphorylation down-regulates activity | 15821101 | SIGNOR-248427 |
| JAK2 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | phosphorylation up-regulates activity | 9575217 | SIGNOR-236463 |
| EIF2AK2 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | phosphorylation up-regulates activity | 25360179 | SIGNOR-279613 |
| FGFR3 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | phosphorylation up-regulates activity | 10918587 | SIGNOR-251139 |
| MAPK3 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | phosphorylation up-regulates | 14551213 | SIGNOR-118600 |
| NEK6 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | phosphorylation up-regulates activity | 20595392 | SIGNOR-273901 |
| PKM | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | phosphorylation up-regulates | 22306293 | SIGNOR-195766 |
| PTPRR | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | dephosphorylation down-regulates activity | 17360477 | SIGNOR-248719 |
| PTPRT | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | dephosphorylation down-regulates activity | 17360477 | SIGNOR-263981 |
| PTPN4 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | dephosphorylation down-regulates activity | 31025789 | SIGNOR-277057 |
| PK | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | phosphorylation up-regulates | 22306293 | SIGNOR-268152 |
| ABL1 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | phosphorylation up-regulates activity | 23383209 | SIGNOR-279675 |
| PTPRG | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | dephosphorylation up-regulates activity | 25624455 | SIGNOR-254729 |
| MAP3K14 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | phosphorylation up-regulates activity | 17543278 | SIGNOR-279341 |
| PTPN9 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | dephosphorylation down-regulates activity | 22394684 | SIGNOR-276976 |
| PTPN1 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | dephosphorylation down-regulates | 15821101 | SIGNOR-135211 |
| PTPN11 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | dephosphorylation down-regulates activity | 16611743 | SIGNOR-272404 |
| RET/PTC2 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | phosphorylation up-regulates activity | 12637586 | SIGNOR-260917 |
| MAPK3 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | phosphorylation up-regulates | 19723038 | SIGNOR-187787 |
| JAK1 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | phosphorylation up-regulates activity | 19723038 | SIGNOR-187775 |
| PTPRK | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | dephosphorylation down-regulates activity | 25612622 | SIGNOR-277060 |
| PTPRD | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | dephosphorylation down-regulates activity | 19478061 | SIGNOR-248442 |
| PTPRO | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | dephosphorylation down-regulates activity | 24708807 | SIGNOR-277062 |
| JAK1 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | phosphorylation up-regulates activity | 26260587 | SIGNOR-249546 |
| PTPN2 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | dephosphorylation down-regulates | 12138178 | SIGNOR-90818 |
| PTPRM | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | dephosphorylation down-regulates activity | 31900385 | SIGNOR-277016 |
| SRC | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | phosphorylation up-regulates activity | 14551213 | SIGNOR-247341 |
| PKM | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | phosphorylation up-regulates activity | 22306293 | SIGNOR-267716 |
| JAK2 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | phosphorylation up-regulates activity | 9575217 | SIGNOR-238638 |
| TNK2 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | phosphorylation up-regulates activity | 28739485 | SIGNOR-279312 |
| FGFR4 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | phosphorylation up-regulates activity | 10918587 | SIGNOR-251142 |
| PTPRD | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | dephosphorylation down-regulates | 19478061 | SIGNOR-185933 |
| HCK | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | phosphorylation up-regulates activity | 12244095 | SIGNOR-251267 |
| PTK6 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | phosphorylation up-regulates activity | 26247733 | SIGNOR-278346 |
| PTPN2 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | dephosphorylation down-regulates activity | 15780598 | SIGNOR-93998 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| FES | phosphorylation up-regulates → | STAT3 PTyr705 | phosphorylation up-regulates → | STAT3 | 15003822 | SIGNOR-278937 |
| PTPN1 | dephosphorylation down-regulates ⊣ | STAT3 PTyr705 | dephosphorylation up-regulates → | STAT3 | 15821101 | SIGNOR-248427 |
| JAK2 | phosphorylation up-regulates → | STAT3 PTyr705 | phosphorylation up-regulates → | STAT3 | 9575217 | SIGNOR-236463 |
| EIF2AK2 | phosphorylation up-regulates → | STAT3 PTyr705 | phosphorylation up-regulates → | STAT3 | 25360179 | SIGNOR-279613 |
| FGFR3 | phosphorylation up-regulates → | STAT3 PTyr705 | phosphorylation up-regulates → | STAT3 | 10918587 | SIGNOR-251139 |
| MAPK3 | phosphorylation up-regulates → | STAT3 PTyr705 | phosphorylation up-regulates → | STAT3 | 14551213 | SIGNOR-118600 |
| NEK6 | phosphorylation up-regulates → | STAT3 PTyr705 | phosphorylation up-regulates → | STAT3 | 20595392 | SIGNOR-273901 |
| PKM | phosphorylation up-regulates → | STAT3 PTyr705 | phosphorylation up-regulates → | STAT3 | 22306293 | SIGNOR-195766 |
| PTPRR | dephosphorylation down-regulates ⊣ | STAT3 PTyr705 | dephosphorylation up-regulates → | STAT3 | 17360477 | SIGNOR-248719 |
| PTPRT | dephosphorylation down-regulates ⊣ | STAT3 PTyr705 | dephosphorylation up-regulates → | STAT3 | 17360477 | SIGNOR-263981 |
| PTPN4 | dephosphorylation down-regulates ⊣ | STAT3 PTyr705 | dephosphorylation up-regulates → | STAT3 | 31025789 | SIGNOR-277057 |
| PK | phosphorylation up-regulates → | STAT3 PTyr705 | phosphorylation up-regulates → | STAT3 | 22306293 | SIGNOR-268152 |
| ABL1 | phosphorylation up-regulates → | STAT3 PTyr705 | phosphorylation up-regulates → | STAT3 | 23383209 | SIGNOR-279675 |
| PTPRG | dephosphorylation down-regulates ⊣ | STAT3 PTyr705 | dephosphorylation down-regulates ⊣ | STAT3 | 25624455 | SIGNOR-254729 |
| MAP3K14 | phosphorylation up-regulates → | STAT3 PTyr705 | phosphorylation up-regulates → | STAT3 | 17543278 | SIGNOR-279341 |
| PTPN9 | dephosphorylation down-regulates ⊣ | STAT3 PTyr705 | dephosphorylation up-regulates → | STAT3 | 22394684 | SIGNOR-276976 |
| PTPN1 | dephosphorylation down-regulates ⊣ | STAT3 PTyr705 | dephosphorylation up-regulates → | STAT3 | 15821101 | SIGNOR-135211 |
| PTPN11 | dephosphorylation down-regulates ⊣ | STAT3 PTyr705 | dephosphorylation up-regulates → | STAT3 | 16611743 | SIGNOR-272404 |
| RET/PTC2 | phosphorylation up-regulates → | STAT3 PTyr705 | phosphorylation up-regulates → | STAT3 | 12637586 | SIGNOR-260917 |
| MAPK3 | phosphorylation up-regulates → | STAT3 PTyr705 | phosphorylation up-regulates → | STAT3 | 19723038 | SIGNOR-187787 |
| JAK1 | phosphorylation up-regulates → | STAT3 PTyr705 | phosphorylation up-regulates → | STAT3 | 19723038 | SIGNOR-187775 |
| PTPRK | dephosphorylation down-regulates ⊣ | STAT3 PTyr705 | dephosphorylation up-regulates → | STAT3 | 25612622 | SIGNOR-277060 |
| PTPRD | dephosphorylation down-regulates ⊣ | STAT3 PTyr705 | dephosphorylation up-regulates → | STAT3 | 19478061 | SIGNOR-248442 |
| PTPRO | dephosphorylation down-regulates ⊣ | STAT3 PTyr705 | dephosphorylation up-regulates → | STAT3 | 24708807 | SIGNOR-277062 |
| JAK1 | phosphorylation up-regulates → | STAT3 PTyr705 | phosphorylation up-regulates → | STAT3 | 26260587 | SIGNOR-249546 |
| PTPN2 | dephosphorylation down-regulates ⊣ | STAT3 PTyr705 | dephosphorylation up-regulates → | STAT3 | 12138178 | SIGNOR-90818 |
| PTPRM | dephosphorylation down-regulates ⊣ | STAT3 PTyr705 | dephosphorylation up-regulates → | STAT3 | 31900385 | SIGNOR-277016 |
| SRC | phosphorylation up-regulates → | STAT3 PTyr705 | phosphorylation up-regulates → | STAT3 | 14551213 | SIGNOR-247341 |
| PKM | phosphorylation up-regulates → | STAT3 PTyr705 | phosphorylation up-regulates → | STAT3 | 22306293 | SIGNOR-267716 |
| JAK2 | phosphorylation up-regulates → | STAT3 PTyr705 | phosphorylation up-regulates → | STAT3 | 9575217 | SIGNOR-238638 |
| TNK2 | phosphorylation up-regulates → | STAT3 PTyr705 | phosphorylation up-regulates → | STAT3 | 28739485 | SIGNOR-279312 |
| FGFR4 | phosphorylation up-regulates → | STAT3 PTyr705 | phosphorylation up-regulates → | STAT3 | 10918587 | SIGNOR-251142 |
| PTPRD | dephosphorylation down-regulates ⊣ | STAT3 PTyr705 | dephosphorylation up-regulates → | STAT3 | 19478061 | SIGNOR-185933 |
| HCK | phosphorylation up-regulates → | STAT3 PTyr705 | phosphorylation up-regulates → | STAT3 | 12244095 | SIGNOR-251267 |
| PTK6 | phosphorylation up-regulates → | STAT3 PTyr705 | phosphorylation up-regulates → | STAT3 | 26247733 | SIGNOR-278346 |
| PTPN2 | dephosphorylation down-regulates ⊣ | STAT3 PTyr705 | dephosphorylation up-regulates → | STAT3 | 15780598 | SIGNOR-93998 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| FES | phosphorylation → up-regulates activity | STAT3 | SIGNOR-278937 |
| PTPN1 | dephosphorylation → down-regulates activity | STAT3 | SIGNOR-248427 |
| JAK2 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-236463 |
| EIF2AK2 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-279613 |
| FGFR3 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-251139 |
| MAPK3 | phosphorylation → up-regulates | STAT3 | SIGNOR-118600 |
| NEK6 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-273901 |
| PKM | phosphorylation → up-regulates | STAT3 | SIGNOR-195766 |
| PTPRR | dephosphorylation → down-regulates activity | STAT3 | SIGNOR-248719 |
| PTPRT | dephosphorylation → down-regulates activity | STAT3 | SIGNOR-263981 |
| PTPN4 | dephosphorylation → down-regulates activity | STAT3 | SIGNOR-277057 |
| PK | phosphorylation → up-regulates | STAT3 | SIGNOR-268152 |
| ABL1 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-279675 |
| PTPRG | dephosphorylation → up-regulates activity | STAT3 | SIGNOR-254729 |
| MAP3K14 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-279341 |
| PTPN9 | dephosphorylation → down-regulates activity | STAT3 | SIGNOR-276976 |
| PTPN1 | dephosphorylation down-regulates | STAT3 | SIGNOR-135211 |
| PTPN11 | dephosphorylation → down-regulates activity | STAT3 | SIGNOR-272404 |
| RET/PTC2 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-260917 |
| MAPK3 | phosphorylation → up-regulates | STAT3 | SIGNOR-187787 |
| JAK1 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-187775 |
| PTPRK | dephosphorylation → down-regulates activity | STAT3 | SIGNOR-277060 |
| PTPRD | dephosphorylation → down-regulates activity | STAT3 | SIGNOR-248442 |
| PTPRO | dephosphorylation → down-regulates activity | STAT3 | SIGNOR-277062 |
| JAK1 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-249546 |
| PTPN2 | dephosphorylation down-regulates | STAT3 | SIGNOR-90818 |
| PTPRM | dephosphorylation → down-regulates activity | STAT3 | SIGNOR-277016 |
| SRC | phosphorylation → up-regulates activity | STAT3 | SIGNOR-247341 |
| PKM | phosphorylation → up-regulates activity | STAT3 | SIGNOR-267716 |
| JAK2 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-238638 |
| TNK2 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-279312 |
| FGFR4 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-251142 |
| PTPRD | dephosphorylation down-regulates | STAT3 | SIGNOR-185933 |
| HCK | phosphorylation → up-regulates activity | STAT3 | SIGNOR-251267 |
| PTK6 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-278346 |
| PTPN2 | dephosphorylation → down-regulates activity | STAT3 | SIGNOR-93998 |
