| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK14 | STAT3 | Ser727 | NTIDLPMsPRTLDSL | phosphorylation up-regulates | 18691976 | SIGNOR-179912 |
| MAP3K1 | STAT3 | Ser727 | NTIDLPMsPRTLDSL | phosphorylation up-regulates activity | 17563747 | SIGNOR-236346 |
| NEK6 | STAT3 | Ser727 | NTIDLPMsPRTLDSL | phosphorylation up-regulates activity | 20595392 | SIGNOR-273902 |
| IRAK1 | STAT3 | Ser727 | NTIDLPMsPRTLDSL | phosphorylation up-regulates | 15465816 | SIGNOR-129685 |
| MAPK8 | STAT3 | Ser727 | NTIDLPMsPRTLDSL | phosphorylation up-regulates activity | 23255093 | SIGNOR-235704 |
| CDK5 | STAT3 | Ser727 | NTIDLPMsPRTLDSL | phosphorylation up-regulates | 15096606 | SIGNOR-124325 |
| MAP3K14 | STAT3 | Ser727 | NTIDLPMsPRTLDSL | phosphorylation up-regulates activity | 17543278 | SIGNOR-279340 |
| EIF2AK2 | STAT3 | Ser727 | NTIDLPMsPRTLDSL | phosphorylation up-regulates activity | 25360179 | SIGNOR-279612 |
| MAPK14 | STAT3 | Ser727 | NTIDLPMsPRTLDSL | phosphorylation up-regulates | 17502367 | SIGNOR-154783 |
| PTPRO | STAT3 | Ser727 | NTIDLPMsPRTLDSL | dephosphorylation down-regulates activity | 24708807 | SIGNOR-277061 |
| MTOR | STAT3 | Ser727 | NTIDLPMsPRTLDSL | phosphorylation up-regulates | 16740698 | SIGNOR-146915 |
| MAPK3 | STAT3 | Ser727 | NTIDLPMsPRTLDSL | phosphorylation up-regulates | 19723038 | SIGNOR-187779 |
| RPS6KA5 | STAT3 | Ser727 | NTIDLPMsPRTLDSL | phosphorylation up-regulates | 12763138 | SIGNOR-101251 |
| MTOR | STAT3 | Ser727 | NTIDLPMsPRTLDSL | phosphorylation up-regulates | 18691976 | SIGNOR-161439 |
| PRKCE | STAT3 | Ser727 | NTIDLPMsPRTLDSL | phosphorylation up-regulates | 16418226 | SIGNOR-143832 |
| DAPK3 | STAT3 | Ser727 | NTIDLPMsPRTLDSL | phosphorylation up-regulates activity | 16219639 | SIGNOR-279702 |
| PPP1CA | STAT3 | Ser727 | NTIDLPMsPRTLDSL | dephosphorylation down-regulates activity | 19440292 | SIGNOR-248563 |
| PRKCD | STAT3 | Ser727 | NTIDLPMsPRTLDSL | phosphorylation up-regulates | 16418226 | SIGNOR-143828 |
| NLK | STAT3 | Ser727 | NTIDLPMsPRTLDSL | phosphorylation up-regulates | 17563747 | SIGNOR-155828 |
| DYRK1A | STAT3 | Ser727 | NTIDLPMsPRTLDSL | phosphorylation up-regulates activity | 31454149 | SIGNOR-279992 |
| BUB1 | STAT3 | Ser727 | NTIDLPMsPRTLDSL | phosphorylation up-regulates activity | 34852826 | SIGNOR-280198 |
| MAPK3 | STAT3 | Ser727 | NTIDLPMsPRTLDSL | phosphorylation up-regulates | 14551213 | SIGNOR-118596 |
| MAPK3 | STAT3 | Ser727 | NTIDLPMsPRTLDSL | phosphorylation up-regulates activity | 14551213 | SIGNOR-249450 |
| MAPK9 | STAT3 | Ser727 | NTIDLPMsPRTLDSL | phosphorylation up-regulates | 18691976 | SIGNOR-179275 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK14 | phosphorylation up-regulates → | STAT3 PSer727 | phosphorylation up-regulates → | STAT3 | 18691976 | SIGNOR-179912 |
| MAP3K1 | phosphorylation up-regulates → | STAT3 PSer727 | phosphorylation up-regulates → | STAT3 | 17563747 | SIGNOR-236346 |
| NEK6 | phosphorylation up-regulates → | STAT3 PSer727 | phosphorylation up-regulates → | STAT3 | 20595392 | SIGNOR-273902 |
| IRAK1 | phosphorylation up-regulates → | STAT3 PSer727 | phosphorylation up-regulates → | STAT3 | 15465816 | SIGNOR-129685 |
| MAPK8 | phosphorylation up-regulates → | STAT3 PSer727 | phosphorylation up-regulates → | STAT3 | 23255093 | SIGNOR-235704 |
| CDK5 | phosphorylation up-regulates → | STAT3 PSer727 | phosphorylation up-regulates → | STAT3 | 15096606 | SIGNOR-124325 |
| MAP3K14 | phosphorylation up-regulates → | STAT3 PSer727 | phosphorylation up-regulates → | STAT3 | 17543278 | SIGNOR-279340 |
| EIF2AK2 | phosphorylation up-regulates → | STAT3 PSer727 | phosphorylation up-regulates → | STAT3 | 25360179 | SIGNOR-279612 |
| MAPK14 | phosphorylation up-regulates → | STAT3 PSer727 | phosphorylation up-regulates → | STAT3 | 17502367 | SIGNOR-154783 |
| PTPRO | dephosphorylation down-regulates ⊣ | STAT3 PSer727 | dephosphorylation up-regulates → | STAT3 | 24708807 | SIGNOR-277061 |
| MTOR | phosphorylation up-regulates → | STAT3 PSer727 | phosphorylation up-regulates → | STAT3 | 16740698 | SIGNOR-146915 |
| MAPK3 | phosphorylation up-regulates → | STAT3 PSer727 | phosphorylation up-regulates → | STAT3 | 19723038 | SIGNOR-187779 |
| RPS6KA5 | phosphorylation up-regulates → | STAT3 PSer727 | phosphorylation up-regulates → | STAT3 | 12763138 | SIGNOR-101251 |
| MTOR | phosphorylation up-regulates → | STAT3 PSer727 | phosphorylation up-regulates → | STAT3 | 18691976 | SIGNOR-161439 |
| PRKCE | phosphorylation up-regulates → | STAT3 PSer727 | phosphorylation up-regulates → | STAT3 | 16418226 | SIGNOR-143832 |
| DAPK3 | phosphorylation up-regulates → | STAT3 PSer727 | phosphorylation up-regulates → | STAT3 | 16219639 | SIGNOR-279702 |
| PPP1CA | dephosphorylation down-regulates ⊣ | STAT3 PSer727 | dephosphorylation up-regulates → | STAT3 | 19440292 | SIGNOR-248563 |
| PRKCD | phosphorylation up-regulates → | STAT3 PSer727 | phosphorylation up-regulates → | STAT3 | 16418226 | SIGNOR-143828 |
| NLK | phosphorylation up-regulates → | STAT3 PSer727 | phosphorylation up-regulates → | STAT3 | 17563747 | SIGNOR-155828 |
| DYRK1A | phosphorylation up-regulates → | STAT3 PSer727 | phosphorylation up-regulates → | STAT3 | 31454149 | SIGNOR-279992 |
| BUB1 | phosphorylation up-regulates → | STAT3 PSer727 | phosphorylation up-regulates → | STAT3 | 34852826 | SIGNOR-280198 |
| MAPK3 | phosphorylation up-regulates → | STAT3 PSer727 | phosphorylation up-regulates → | STAT3 | 14551213 | SIGNOR-118596 |
| MAPK3 | phosphorylation up-regulates → | STAT3 PSer727 | phosphorylation up-regulates → | STAT3 | 14551213 | SIGNOR-249450 |
| MAPK9 | phosphorylation up-regulates → | STAT3 PSer727 | phosphorylation up-regulates → | STAT3 | 18691976 | SIGNOR-179275 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK14 | phosphorylation → up-regulates | STAT3 | SIGNOR-179912 |
| MAP3K1 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-236346 |
| NEK6 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-273902 |
| IRAK1 | phosphorylation → up-regulates | STAT3 | SIGNOR-129685 |
| MAPK8 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-235704 |
| CDK5 | phosphorylation → up-regulates | STAT3 | SIGNOR-124325 |
| MAP3K14 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-279340 |
| EIF2AK2 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-279612 |
| MAPK14 | phosphorylation → up-regulates | STAT3 | SIGNOR-154783 |
| PTPRO | dephosphorylation → down-regulates activity | STAT3 | SIGNOR-277061 |
| MTOR | phosphorylation → up-regulates | STAT3 | SIGNOR-146915 |
| MAPK3 | phosphorylation → up-regulates | STAT3 | SIGNOR-187779 |
| RPS6KA5 | phosphorylation → up-regulates | STAT3 | SIGNOR-101251 |
| MTOR | phosphorylation → up-regulates | STAT3 | SIGNOR-161439 |
| PRKCE | phosphorylation → up-regulates | STAT3 | SIGNOR-143832 |
| DAPK3 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-279702 |
| PPP1CA | dephosphorylation → down-regulates activity | STAT3 | SIGNOR-248563 |
| PRKCD | phosphorylation → up-regulates | STAT3 | SIGNOR-143828 |
| NLK | phosphorylation → up-regulates | STAT3 | SIGNOR-155828 |
| DYRK1A | phosphorylation → up-regulates activity | STAT3 | SIGNOR-279992 |
| BUB1 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-280198 |
| MAPK3 | phosphorylation → up-regulates | STAT3 | SIGNOR-118596 |
| MAPK3 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-249450 |
| MAPK9 | phosphorylation → up-regulates | STAT3 | SIGNOR-179275 |
