| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GRK2 | OPRD1 | Ser363 | RVTACTPsDGPGGGA | phosphorylation down-regulates activity | 11040053 | SIGNOR-249660 |
| PRKCE | OPRD1 | Ser344 | CGRPDPSsFSRAREA | phosphorylation unknown | 11085981 | SIGNOR-249064 |
| PRKCD | OPRD1 | Ser344 | CGRPDPSsFSRAREA | phosphorylation unknown | 11085981 | SIGNOR-249063 |
| GRK2 | OPRD1 | Thr358 | ATARERVtACTPSDG | phosphorylation down-regulates activity | 11040053 | SIGNOR-251457 |
| PRKCA | OPRD1 | Ser344 | CGRPDPSsFSRAREA | phosphorylation unknown | 11085981 | SIGNOR-249062 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GRK2 | phosphorylation up-regulates → | OPRD1 PSer363 | phosphorylation down-regulates ⊣ | OPRD1 | 11040053 | SIGNOR-249660 |
| PRKCE | phosphorylation up-regulates → | OPRD1 PSer344 | phosphorylation down-regulates ⊣ | OPRD1 | 11085981 | SIGNOR-249064 |
| PRKCD | phosphorylation up-regulates → | OPRD1 PSer344 | phosphorylation down-regulates ⊣ | OPRD1 | 11085981 | SIGNOR-249063 |
| GRK2 | phosphorylation up-regulates → | OPRD1 PThr358 | phosphorylation down-regulates ⊣ | OPRD1 | 11040053 | SIGNOR-251457 |
| PRKCA | phosphorylation up-regulates → | OPRD1 PSer344 | phosphorylation down-regulates ⊣ | OPRD1 | 11085981 | SIGNOR-249062 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GRK2 | phosphorylation → down-regulates activity | OPRD1 | SIGNOR-249660 |
| PRKCE | phosphorylation → unknown | OPRD1 | SIGNOR-249064 |
| PRKCD | phosphorylation → unknown | OPRD1 | SIGNOR-249063 |
| GRK2 | phosphorylation → down-regulates activity | OPRD1 | SIGNOR-251457 |
| PRKCA | phosphorylation → unknown | OPRD1 | SIGNOR-249062 |
