Summary

Name OPRD1
Full Name Delta-type opioid receptor
Synonyms D-OR-1, DOR-1 | OPRD
Primary ID P41143
Links - -
Type protein
Relations 42
Inhibitors PPBP; Quadazocine; Naltriben; Naltrindole; beta-Funaltrexamine; (4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-6-(phenylmethylene)-1,2,4,5,7a,13-hexahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one; Norbinaltorphimine; naltrexone; naloxone; alvimopan; methylnaltrexone
Function G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ img/unknown.png phosphorylation OPRD1 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation OPRD1 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation OPRD1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation OPRD1 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation OPRD1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation OPRD1 0.14
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation OPRD1 0.14
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png chemical inhibition OPRD1 0.14
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png chemical inhibition OPRD1 0.14
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png chemical inhibition OPRD1 0.14
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates img/direct-activation.png chemical activation OPRD1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition OPRD1 0.14
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation OPRD1 0.14
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png chemical inhibition OPRD1 0.14
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png chemical inhibition OPRD1 0.14
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation OPRD1 0.14
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation OPRD1 0.14
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation OPRD1 0.14
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation OPRD1 0.14
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation OPRD1 0.14
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation OPRD1 0.14
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation OPRD1 0.14
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation OPRD1 0.14
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation OPRD1 0.14
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation OPRD1 0.14
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation OPRD1 0.14
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation OPRD1 0.14
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation OPRD1 0.14
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png chemical inhibition OPRD1 0.14
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation OPRD1 0.14
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation OPRD1 0.14
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png chemical inhibition OPRD1 0.14
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation OPRD1 0.14
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png chemical inhibition OPRD1 0.14
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png binding GNAI3 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition OPRD1 0.14
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png chemical activation OPRD1 0.14
Publications: 1 Organism: Cricetulus Longicaudatus
+ up-regulates activity img/direct-activation.png binding GNAI1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition OPRD1 0.14
Publications: 1 Organism: Cricetulus Longicaudatus
+ up-regulates activity img/direct-activation.png chemical activation OPRD1 0.14
Publications: 1 Organism: Cricetulus Longicaudatus
+ up-regulates activity img/direct-activation.png binding GNA14 0.14
Publications: 1 Organism: Homo Sapiens