| Name | STAT1 |
| ID | P42224 |
| Role | substrate |
| Enzymatic Domains |
SH2 573-670 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| JAK1 | STAT1 | Tyr701 | DGPKGTGyIKTELIS | phosphorylation up-regulates activity | 7657660 | SIGNOR-30905 |
| JAK1 | STAT1 | Tyr701 | DGPKGTGyIKTELIS | phosphorylation up-regulates activity | 11823427 | SIGNOR-236373 |
| PTPN2 | STAT1 | Tyr701 | DGPKGTGyIKTELIS | dephosphorylation down-regulates activity | 12138178 | SIGNOR-248402 |
| PRKCD | STAT1 | Ser727 | TDNLLPMsPEEFDEV | phosphorylation up-regulates | 17502367 | SIGNOR-154791 |
| CKM complex | STAT1 | Ser727 | TDNLLPMsPEEFDEV | phosphorylation up-regulates activity | 29239838 | SIGNOR-273182 |
| ABL1 | STAT1 | Tyr701 | DGPKGTGyIKTELIS | phosphorylation up-regulates activity | 33644712 | SIGNOR-279491 |
| JAK1 | STAT1 | – | phosphorylation up-regulates | 21576360 | SIGNOR-256247 | |
| FGFR3 | STAT1 | Tyr701 | DGPKGTGyIKTELIS | phosphorylation up-regulates activity | 10918587 | SIGNOR-251138 |
| CDK8 | STAT1 | Ser727 | TDNLLPMsPEEFDEV | phosphorylation up-regulates activity | 29239838 | SIGNOR-273179 |
| PTPRG | STAT1 | Tyr701 | DGPKGTGyIKTELIS | dephosphorylation up-regulates activity | 25624455 | SIGNOR-254727 |
| PTPN2 | STAT1 | Tyr701 | DGPKGTGyIKTELIS | dephosphorylation down-regulates | 12138178 | SIGNOR-90814 |
| TYK2 | STAT1 | Tyr701 | DGPKGTGyIKTELIS | phosphorylation up-regulates activity | 7657660 | SIGNOR-246943 |
| TNK2 | STAT1 | Tyr701 | DGPKGTGyIKTELIS | phosphorylation up-regulates activity | 28739485 | SIGNOR-278348 |
| MAPK14 | STAT1 | Ser727 | TDNLLPMsPEEFDEV | phosphorylation up-regulates activity | 17502367 | SIGNOR-154779 |
| FGFR4 | STAT1 | Tyr701 | DGPKGTGyIKTELIS | phosphorylation up-regulates activity | 10918587 | SIGNOR-251141 |
| CAMK2B | STAT1 | Ser727 | TDNLLPMsPEEFDEV | phosphorylation up-regulates | 17502367 | SIGNOR-154771 |
| RET | STAT1 | Tyr701 | DGPKGTGyIKTELIS | phosphorylation up-regulates activity | 27994058 | SIGNOR-279276 |
| JAK2 | STAT1 | – | phosphorylation up-regulates | 21576360 | SIGNOR-256248 | |
| CHUK | STAT1 | – | phosphorylation up-regulates activity | 27992555 | SIGNOR-279732 | |
| EGFR | STAT1 | – | phosphorylation up-regulates | 14967450 | SIGNOR-121962 | |
| SGK1 | STAT1 | – | phosphorylation up-regulates activity | 30382187 | SIGNOR-279281 | |
| MAPK8 | STAT1 | Tyr701 | DGPKGTGyIKTELIS | phosphorylation up-regulates activity | 24913968 | SIGNOR-251101 |
| PTPN11 | STAT1 | Tyr701 | DGPKGTGyIKTELIS | dephosphorylation down-regulates activity | 12270932 | SIGNOR-248672 |
| PTPN11 | STAT1 | Ser727 | TDNLLPMsPEEFDEV | dephosphorylation down-regulates activity | 12270932 | SIGNOR-248673 |
| CAMK2G | STAT1 | Ser727 | TDNLLPMsPEEFDEV | phosphorylation up-regulates activity | 11972023 | SIGNOR-250706 |
| EGFR | STAT1 | – | phosphorylation up-regulates | 22693070 | SIGNOR-235689 | |
| JAK1 | STAT1 | – | phosphorylation up-regulates activity | 9020188 | SIGNOR-236239 | |
| PTPN2 | STAT1 | – | dephosphorylation down-regulates activity | 15780598 | SIGNOR-133279 | |
| JAK2 | STAT1 | – | phosphorylation up-regulates | 7888666 | SIGNOR-255071 | |
| KIT | STAT1 | Tyr701 | DGPKGTGyIKTELIS | phosphorylation up-regulates activity | 21135090 | SIGNOR-251365 |
| JAK2 | STAT1 | Tyr701 | DGPKGTGyIKTELIS | phosphorylation up-regulates | 15322115 | SIGNOR-235709 |
| SRC | STAT1 | Tyr701 | DGPKGTGyIKTELIS | phosphorylation up-regulates activity | 14978237 | SIGNOR-235696 |
| IKBKE | STAT1 | Ser727 | TDNLLPMsPEEFDEV | phosphorylation up-regulates | 17502367 | SIGNOR-154775 |
| TEK | STAT1 | Tyr701 | DGPKGTGyIKTELIS | phosphorylation up-regulates activity | 18401423 | SIGNOR-279131 |
| RET | STAT1 | Ser727 | TDNLLPMsPEEFDEV | phosphorylation up-regulates activity | 27994058 | SIGNOR-279277 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| JAK1 | phosphorylation up-regulates → | STAT1 PTyr701 | phosphorylation up-regulates → | STAT1 | 7657660 | SIGNOR-30905 |
| JAK1 | phosphorylation up-regulates → | STAT1 PTyr701 | phosphorylation up-regulates → | STAT1 | 11823427 | SIGNOR-236373 |
| PTPN2 | dephosphorylation down-regulates ⊣ | STAT1 PTyr701 | dephosphorylation up-regulates → | STAT1 | 12138178 | SIGNOR-248402 |
| PRKCD | phosphorylation up-regulates → | STAT1 PSer727 | phosphorylation up-regulates → | STAT1 | 17502367 | SIGNOR-154791 |
| CKM complex | phosphorylation up-regulates → | STAT1 PSer727 | phosphorylation up-regulates → | STAT1 | 29239838 | SIGNOR-273182 |
| ABL1 | phosphorylation up-regulates → | STAT1 PTyr701 | phosphorylation up-regulates → | STAT1 | 33644712 | SIGNOR-279491 |
| FGFR3 | phosphorylation up-regulates → | STAT1 PTyr701 | phosphorylation up-regulates → | STAT1 | 10918587 | SIGNOR-251138 |
| CDK8 | phosphorylation up-regulates → | STAT1 PSer727 | phosphorylation up-regulates → | STAT1 | 29239838 | SIGNOR-273179 |
| PTPRG | dephosphorylation down-regulates ⊣ | STAT1 PTyr701 | dephosphorylation down-regulates ⊣ | STAT1 | 25624455 | SIGNOR-254727 |
| PTPN2 | dephosphorylation down-regulates ⊣ | STAT1 PTyr701 | dephosphorylation up-regulates → | STAT1 | 12138178 | SIGNOR-90814 |
| TYK2 | phosphorylation up-regulates → | STAT1 PTyr701 | phosphorylation up-regulates → | STAT1 | 7657660 | SIGNOR-246943 |
| TNK2 | phosphorylation up-regulates → | STAT1 PTyr701 | phosphorylation up-regulates → | STAT1 | 28739485 | SIGNOR-278348 |
| MAPK14 | phosphorylation up-regulates → | STAT1 PSer727 | phosphorylation up-regulates → | STAT1 | 17502367 | SIGNOR-154779 |
| FGFR4 | phosphorylation up-regulates → | STAT1 PTyr701 | phosphorylation up-regulates → | STAT1 | 10918587 | SIGNOR-251141 |
| CAMK2B | phosphorylation up-regulates → | STAT1 PSer727 | phosphorylation up-regulates → | STAT1 | 17502367 | SIGNOR-154771 |
| RET | phosphorylation up-regulates → | STAT1 PTyr701 | phosphorylation up-regulates → | STAT1 | 27994058 | SIGNOR-279276 |
| MAPK8 | phosphorylation up-regulates → | STAT1 PTyr701 | phosphorylation up-regulates → | STAT1 | 24913968 | SIGNOR-251101 |
| PTPN11 | dephosphorylation down-regulates ⊣ | STAT1 PTyr701 | dephosphorylation up-regulates → | STAT1 | 12270932 | SIGNOR-248672 |
| PTPN11 | dephosphorylation down-regulates ⊣ | STAT1 PSer727 | dephosphorylation up-regulates → | STAT1 | 12270932 | SIGNOR-248673 |
| CAMK2G | phosphorylation up-regulates → | STAT1 PSer727 | phosphorylation up-regulates → | STAT1 | 11972023 | SIGNOR-250706 |
| KIT | phosphorylation up-regulates → | STAT1 PTyr701 | phosphorylation up-regulates → | STAT1 | 21135090 | SIGNOR-251365 |
| JAK2 | phosphorylation up-regulates → | STAT1 PTyr701 | phosphorylation up-regulates → | STAT1 | 15322115 | SIGNOR-235709 |
| SRC | phosphorylation up-regulates → | STAT1 PTyr701 | phosphorylation up-regulates → | STAT1 | 14978237 | SIGNOR-235696 |
| IKBKE | phosphorylation up-regulates → | STAT1 PSer727 | phosphorylation up-regulates → | STAT1 | 17502367 | SIGNOR-154775 |
| TEK | phosphorylation up-regulates → | STAT1 PTyr701 | phosphorylation up-regulates → | STAT1 | 18401423 | SIGNOR-279131 |
| RET | phosphorylation up-regulates → | STAT1 PSer727 | phosphorylation up-regulates → | STAT1 | 27994058 | SIGNOR-279277 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| JAK1 | phosphorylation → up-regulates activity | STAT1 | SIGNOR-30905 |
| JAK1 | phosphorylation → up-regulates activity | STAT1 | SIGNOR-236373 |
| PTPN2 | dephosphorylation → down-regulates activity | STAT1 | SIGNOR-248402 |
| PRKCD | phosphorylation → up-regulates | STAT1 | SIGNOR-154791 |
| CKM complex | phosphorylation → up-regulates activity | STAT1 | SIGNOR-273182 |
| ABL1 | phosphorylation → up-regulates activity | STAT1 | SIGNOR-279491 |
| JAK1 | phosphorylation → up-regulates | STAT1 | SIGNOR-256247 |
| FGFR3 | phosphorylation → up-regulates activity | STAT1 | SIGNOR-251138 |
| CDK8 | phosphorylation → up-regulates activity | STAT1 | SIGNOR-273179 |
| PTPRG | dephosphorylation → up-regulates activity | STAT1 | SIGNOR-254727 |
| PTPN2 | dephosphorylation down-regulates | STAT1 | SIGNOR-90814 |
| TYK2 | phosphorylation → up-regulates activity | STAT1 | SIGNOR-246943 |
| TNK2 | phosphorylation → up-regulates activity | STAT1 | SIGNOR-278348 |
| MAPK14 | phosphorylation → up-regulates activity | STAT1 | SIGNOR-154779 |
| FGFR4 | phosphorylation → up-regulates activity | STAT1 | SIGNOR-251141 |
| CAMK2B | phosphorylation → up-regulates | STAT1 | SIGNOR-154771 |
| RET | phosphorylation → up-regulates activity | STAT1 | SIGNOR-279276 |
| JAK2 | phosphorylation → up-regulates | STAT1 | SIGNOR-256248 |
| CHUK | phosphorylation → up-regulates activity | STAT1 | SIGNOR-279732 |
| EGFR | phosphorylation → up-regulates | STAT1 | SIGNOR-121962 |
| SGK1 | phosphorylation → up-regulates activity | STAT1 | SIGNOR-279281 |
| MAPK8 | phosphorylation → up-regulates activity | STAT1 | SIGNOR-251101 |
| PTPN11 | dephosphorylation → down-regulates activity | STAT1 | SIGNOR-248672 |
| PTPN11 | dephosphorylation → down-regulates activity | STAT1 | SIGNOR-248673 |
| CAMK2G | phosphorylation → up-regulates activity | STAT1 | SIGNOR-250706 |
| EGFR | phosphorylation → up-regulates | STAT1 | SIGNOR-235689 |
| JAK1 | phosphorylation → up-regulates activity | STAT1 | SIGNOR-236239 |
| PTPN2 | dephosphorylation → down-regulates activity | STAT1 | SIGNOR-133279 |
| JAK2 | phosphorylation → up-regulates | STAT1 | SIGNOR-255071 |
| KIT | phosphorylation → up-regulates activity | STAT1 | SIGNOR-251365 |
| JAK2 | phosphorylation → up-regulates | STAT1 | SIGNOR-235709 |
| SRC | phosphorylation → up-regulates activity | STAT1 | SIGNOR-235696 |
| IKBKE | phosphorylation → up-regulates | STAT1 | SIGNOR-154775 |
| TEK | phosphorylation → up-regulates activity | STAT1 | SIGNOR-279131 |
| RET | phosphorylation → up-regulates activity | STAT1 | SIGNOR-279277 |