Summary

Name STAT1
Full Name Signal transducer and activator of transcription 1-alpha/beta
Synonyms Transcription factor ISGF-3 components p91/p84
Primary ID P42224
Links - -
Type protein
Relations 60
Pathways EGFR, P38 Signaling
Function Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus (PubMed:28753426). ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated (PubMed:26479788). It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation STAT1 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation STAT1 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation STAT1 0.36
Publications: 2 Organism: Homo Sapiens
Pathways:EGFR
+ up-regulates activity img/direct-activation.png phosphorylation STAT1 0.22
Publications: 1
+ up-regulates img/direct-activation.png phosphorylation STAT1 0.34
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation STAT1 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling
+ up-regulates activity img/direct-activation.png phosphorylation STAT1 0.34
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation STAT1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation STAT1 0.48
Publications: 3 Organism: In Vitro, Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation STAT1 0.45
Publications: 3 Organism: Homo Sapiens,
Tissue: Skeletal Muscle
+ up-regulates activity img/direct-activation.png phosphorylation STAT1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation STAT1 0.14
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation STAT1 0.36
Publications: 1 Organism: Homo Sapiens
Tissue: Lung
Pathways:EGFR
+ down-regulates img/direct_inhibition.png dephosphorylation STAT1 0.46
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation STAT1 0.49
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation STAT1 0.14
Publications: 1 Organism: Mus Musculus
Pathways:EGFR
+ down-regulates activity img/direct_inhibition.png dephosphorylation STAT1 0.46
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation S100A10 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation MMP13 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/indirect-activation.png transcriptional regulation CIITA 0.23
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ down-regulates img/direct_inhibition.png binding NfKb-p65/p50 0.14
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding JAK1/STAT1/STAT3 0.22
Publications: 1 Organism: Mus Musculus
Pathways:EGFR
+ up-regulates img/direct-activation.png phosphorylation STAT1 0.28
Publications: 2 Organism: Homo Sapiens
Pathways:EGFR
+ form complex img/form-complex.png binding ISGF3 complex 0.14
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png transcriptional regulation CIITA 0.23
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL12B 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TAP1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png STAT1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding STAT1 0.57
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SOCS1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding RELA 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation STAT1 0.48
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ up-regulates img/indirect-activation.png STAT1 0.38
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding STAT1 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CIITA 0.23
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png M1 polarization 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation STAT1 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Esophageal Cancer Cell Line
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation MUC4 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation SOCS3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding STAT1 0.59
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding IRF2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL12A 0.31
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NOS2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IRF7 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation KRT17 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TLR3 0.14
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding STAT1/STAT3 0.14
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png binding STAT1 0.35
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation STAT1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding STAT1 0.39
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR, P38 Signaling
+ up-regulates img/indirect-activation.png TBX21 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation STAT1 0.14
Publications: 1 Organism: Homo Sapiens