| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CKM complex | STAT1 | Ser727 | TDNLLPMsPEEFDEV | phosphorylation up-regulates activity | 29239838 | SIGNOR-273182 |
| CDK8 | STAT1 | Ser727 | TDNLLPMsPEEFDEV | phosphorylation up-regulates activity | 29239838 | SIGNOR-273179 |
| MAPK14 | STAT1 | Ser727 | TDNLLPMsPEEFDEV | phosphorylation up-regulates activity | 17502367 | SIGNOR-154779 |
| PRKCD | STAT1 | Ser727 | TDNLLPMsPEEFDEV | phosphorylation up-regulates | 17502367 | SIGNOR-154791 |
| CAMK2B | STAT1 | Ser727 | TDNLLPMsPEEFDEV | phosphorylation up-regulates | 17502367 | SIGNOR-154771 |
| PTPN11 | STAT1 | Ser727 | TDNLLPMsPEEFDEV | dephosphorylation down-regulates activity | 12270932 | SIGNOR-248673 |
| CAMK2G | STAT1 | Ser727 | TDNLLPMsPEEFDEV | phosphorylation up-regulates activity | 11972023 | SIGNOR-250706 |
| IKBKE | STAT1 | Ser727 | TDNLLPMsPEEFDEV | phosphorylation up-regulates | 17502367 | SIGNOR-154775 |
| RET | STAT1 | Ser727 | TDNLLPMsPEEFDEV | phosphorylation up-regulates activity | 27994058 | SIGNOR-279277 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CKM complex | phosphorylation up-regulates → | STAT1 PSer727 | phosphorylation up-regulates → | STAT1 | 29239838 | SIGNOR-273182 |
| CDK8 | phosphorylation up-regulates → | STAT1 PSer727 | phosphorylation up-regulates → | STAT1 | 29239838 | SIGNOR-273179 |
| MAPK14 | phosphorylation up-regulates → | STAT1 PSer727 | phosphorylation up-regulates → | STAT1 | 17502367 | SIGNOR-154779 |
| PRKCD | phosphorylation up-regulates → | STAT1 PSer727 | phosphorylation up-regulates → | STAT1 | 17502367 | SIGNOR-154791 |
| CAMK2B | phosphorylation up-regulates → | STAT1 PSer727 | phosphorylation up-regulates → | STAT1 | 17502367 | SIGNOR-154771 |
| PTPN11 | dephosphorylation down-regulates ⊣ | STAT1 PSer727 | dephosphorylation up-regulates → | STAT1 | 12270932 | SIGNOR-248673 |
| CAMK2G | phosphorylation up-regulates → | STAT1 PSer727 | phosphorylation up-regulates → | STAT1 | 11972023 | SIGNOR-250706 |
| IKBKE | phosphorylation up-regulates → | STAT1 PSer727 | phosphorylation up-regulates → | STAT1 | 17502367 | SIGNOR-154775 |
| RET | phosphorylation up-regulates → | STAT1 PSer727 | phosphorylation up-regulates → | STAT1 | 27994058 | SIGNOR-279277 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CKM complex | phosphorylation → up-regulates activity | STAT1 | SIGNOR-273182 |
| CDK8 | phosphorylation → up-regulates activity | STAT1 | SIGNOR-273179 |
| MAPK14 | phosphorylation → up-regulates activity | STAT1 | SIGNOR-154779 |
| PRKCD | phosphorylation → up-regulates | STAT1 | SIGNOR-154791 |
| CAMK2B | phosphorylation → up-regulates | STAT1 | SIGNOR-154771 |
| PTPN11 | dephosphorylation → down-regulates activity | STAT1 | SIGNOR-248673 |
| CAMK2G | phosphorylation → up-regulates activity | STAT1 | SIGNOR-250706 |
| IKBKE | phosphorylation → up-regulates | STAT1 | SIGNOR-154775 |
| RET | phosphorylation → up-regulates activity | STAT1 | SIGNOR-279277 |
