| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN11 | STAT1 | Tyr701 | DGPKGTGyIKTELIS | dephosphorylation down-regulates activity | 12270932 | SIGNOR-248672 |
| KIT | STAT1 | Tyr701 | DGPKGTGyIKTELIS | phosphorylation up-regulates activity | 21135090 | SIGNOR-251365 |
| JAK1 | STAT1 | Tyr701 | DGPKGTGyIKTELIS | phosphorylation up-regulates activity | 7657660 | SIGNOR-30905 |
| JAK1 | STAT1 | Tyr701 | DGPKGTGyIKTELIS | phosphorylation up-regulates activity | 11823427 | SIGNOR-236373 |
| JAK2 | STAT1 | Tyr701 | DGPKGTGyIKTELIS | phosphorylation up-regulates | 15322115 | SIGNOR-235709 |
| SRC | STAT1 | Tyr701 | DGPKGTGyIKTELIS | phosphorylation up-regulates activity | 14978237 | SIGNOR-235696 |
| TEK | STAT1 | Tyr701 | DGPKGTGyIKTELIS | phosphorylation up-regulates activity | 18401423 | SIGNOR-279131 |
| PTPN2 | STAT1 | Tyr701 | DGPKGTGyIKTELIS | dephosphorylation down-regulates activity | 12138178 | SIGNOR-248402 |
| ABL1 | STAT1 | Tyr701 | DGPKGTGyIKTELIS | phosphorylation up-regulates activity | 33644712 | SIGNOR-279491 |
| FGFR3 | STAT1 | Tyr701 | DGPKGTGyIKTELIS | phosphorylation up-regulates activity | 10918587 | SIGNOR-251138 |
| PTPRG | STAT1 | Tyr701 | DGPKGTGyIKTELIS | dephosphorylation up-regulates activity | 25624455 | SIGNOR-254727 |
| PTPN2 | STAT1 | Tyr701 | DGPKGTGyIKTELIS | dephosphorylation down-regulates | 12138178 | SIGNOR-90814 |
| TYK2 | STAT1 | Tyr701 | DGPKGTGyIKTELIS | phosphorylation up-regulates activity | 7657660 | SIGNOR-246943 |
| TNK2 | STAT1 | Tyr701 | DGPKGTGyIKTELIS | phosphorylation up-regulates activity | 28739485 | SIGNOR-278348 |
| FGFR4 | STAT1 | Tyr701 | DGPKGTGyIKTELIS | phosphorylation up-regulates activity | 10918587 | SIGNOR-251141 |
| RET | STAT1 | Tyr701 | DGPKGTGyIKTELIS | phosphorylation up-regulates activity | 27994058 | SIGNOR-279276 |
| MAPK8 | STAT1 | Tyr701 | DGPKGTGyIKTELIS | phosphorylation up-regulates activity | 24913968 | SIGNOR-251101 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN11 | dephosphorylation down-regulates ⊣ | STAT1 PTyr701 | dephosphorylation up-regulates → | STAT1 | 12270932 | SIGNOR-248672 |
| KIT | phosphorylation up-regulates → | STAT1 PTyr701 | phosphorylation up-regulates → | STAT1 | 21135090 | SIGNOR-251365 |
| JAK1 | phosphorylation up-regulates → | STAT1 PTyr701 | phosphorylation up-regulates → | STAT1 | 7657660 | SIGNOR-30905 |
| JAK1 | phosphorylation up-regulates → | STAT1 PTyr701 | phosphorylation up-regulates → | STAT1 | 11823427 | SIGNOR-236373 |
| JAK2 | phosphorylation up-regulates → | STAT1 PTyr701 | phosphorylation up-regulates → | STAT1 | 15322115 | SIGNOR-235709 |
| SRC | phosphorylation up-regulates → | STAT1 PTyr701 | phosphorylation up-regulates → | STAT1 | 14978237 | SIGNOR-235696 |
| TEK | phosphorylation up-regulates → | STAT1 PTyr701 | phosphorylation up-regulates → | STAT1 | 18401423 | SIGNOR-279131 |
| PTPN2 | dephosphorylation down-regulates ⊣ | STAT1 PTyr701 | dephosphorylation up-regulates → | STAT1 | 12138178 | SIGNOR-248402 |
| ABL1 | phosphorylation up-regulates → | STAT1 PTyr701 | phosphorylation up-regulates → | STAT1 | 33644712 | SIGNOR-279491 |
| FGFR3 | phosphorylation up-regulates → | STAT1 PTyr701 | phosphorylation up-regulates → | STAT1 | 10918587 | SIGNOR-251138 |
| PTPRG | dephosphorylation down-regulates ⊣ | STAT1 PTyr701 | dephosphorylation down-regulates ⊣ | STAT1 | 25624455 | SIGNOR-254727 |
| PTPN2 | dephosphorylation down-regulates ⊣ | STAT1 PTyr701 | dephosphorylation up-regulates → | STAT1 | 12138178 | SIGNOR-90814 |
| TYK2 | phosphorylation up-regulates → | STAT1 PTyr701 | phosphorylation up-regulates → | STAT1 | 7657660 | SIGNOR-246943 |
| TNK2 | phosphorylation up-regulates → | STAT1 PTyr701 | phosphorylation up-regulates → | STAT1 | 28739485 | SIGNOR-278348 |
| FGFR4 | phosphorylation up-regulates → | STAT1 PTyr701 | phosphorylation up-regulates → | STAT1 | 10918587 | SIGNOR-251141 |
| RET | phosphorylation up-regulates → | STAT1 PTyr701 | phosphorylation up-regulates → | STAT1 | 27994058 | SIGNOR-279276 |
| MAPK8 | phosphorylation up-regulates → | STAT1 PTyr701 | phosphorylation up-regulates → | STAT1 | 24913968 | SIGNOR-251101 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN11 | dephosphorylation → down-regulates activity | STAT1 | SIGNOR-248672 |
| KIT | phosphorylation → up-regulates activity | STAT1 | SIGNOR-251365 |
| JAK1 | phosphorylation → up-regulates activity | STAT1 | SIGNOR-30905 |
| JAK1 | phosphorylation → up-regulates activity | STAT1 | SIGNOR-236373 |
| JAK2 | phosphorylation → up-regulates | STAT1 | SIGNOR-235709 |
| SRC | phosphorylation → up-regulates activity | STAT1 | SIGNOR-235696 |
| TEK | phosphorylation → up-regulates activity | STAT1 | SIGNOR-279131 |
| PTPN2 | dephosphorylation → down-regulates activity | STAT1 | SIGNOR-248402 |
| ABL1 | phosphorylation → up-regulates activity | STAT1 | SIGNOR-279491 |
| FGFR3 | phosphorylation → up-regulates activity | STAT1 | SIGNOR-251138 |
| PTPRG | dephosphorylation → up-regulates activity | STAT1 | SIGNOR-254727 |
| PTPN2 | dephosphorylation down-regulates | STAT1 | SIGNOR-90814 |
| TYK2 | phosphorylation → up-regulates activity | STAT1 | SIGNOR-246943 |
| TNK2 | phosphorylation → up-regulates activity | STAT1 | SIGNOR-278348 |
| FGFR4 | phosphorylation → up-regulates activity | STAT1 | SIGNOR-251141 |
| RET | phosphorylation → up-regulates activity | STAT1 | SIGNOR-279276 |
| MAPK8 | phosphorylation → up-regulates activity | STAT1 | SIGNOR-251101 |
