| Name | STAT5A |
| ID | P42229 |
| Role | substrate |
| Enzymatic Domains |
SH2 589-686 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| JAK2 | STAT5A | Tyr694 | LAKAVDGyVKPQIKQ | phosphorylation up-regulates | 9575217 | SIGNOR-56827 |
| SRC | STAT5A | Tyr694 | LAKAVDGyVKPQIKQ | phosphorylation up-regulates | 11641791 | SIGNOR-111078 |
| JAK3 | STAT5A | Tyr694 | LAKAVDGyVKPQIKQ | phosphorylation up-regulates | 18250158 | SIGNOR-160672 |
| PTEN | STAT5A | – | dephosphorylation down-regulates | 20596030 | SIGNOR-166481 | |
| Gbeta | STAT5A | – | phosphorylation up-regulates | 10194762 | SIGNOR-270004 | |
| ERK1/2 | STAT5A | – | phosphorylation up-regulates | 10194762 | SIGNOR-270136 | |
| BTK | STAT5A | Tyr694 | LAKAVDGyVKPQIKQ | phosphorylation up-regulates activity | 11413148 | SIGNOR-250603 |
| FLT3 | STAT5A | – | phosphorylation up-regulates activity | 12796379 | SIGNOR-261516 | |
| PTPRG | STAT5A | Tyr694 | LAKAVDGyVKPQIKQ | dephosphorylation up-regulates activity | 25624455 | SIGNOR-254730 |
| PTPN2 | STAT5A | – | dephosphorylation down-regulates activity | 15780598 | SIGNOR-133547 | |
| MAPK1 | STAT5A | Ser780 | DSLDSRLsPPAGLFT | phosphorylation up-regulates | 10194762 | SIGNOR-66239 |
| BCR-ABL | STAT5A | – | phosphorylation up-regulates activity | 8642285 | SIGNOR-255813 | |
| FLT3 | STAT5A | Tyr694 | LAKAVDGyVKPQIKQ | phosphorylation up-regulates activity | 17356133 | SIGNOR-245069 |
| JAK2 | STAT5A | – | phosphorylation up-regulates activity | 9575217 | SIGNOR-249507 | |
| JAK3 | STAT5A | Tyr694 | LAKAVDGyVKPQIKQ | phosphorylation up-regulates | 19088846 | SIGNOR-182817 |
| ERBB4 | STAT5A | Tyr694 | LAKAVDGyVKPQIKQ | phosphorylation up-regulates activity | 15863494 | SIGNOR-279711 |
| PTPN1 | STAT5A | Tyr694 | LAKAVDGyVKPQIKQ | dephosphorylation down-regulates activity | 10993888 | SIGNOR-248428 |
| MAPK3 | STAT5A | Ser780 | DSLDSRLsPPAGLFT | phosphorylation up-regulates | 10194762 | SIGNOR-66247 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| JAK2 | phosphorylation up-regulates → | STAT5A PTyr694 | phosphorylation up-regulates → | STAT5A | 9575217 | SIGNOR-56827 |
| SRC | phosphorylation up-regulates → | STAT5A PTyr694 | phosphorylation up-regulates → | STAT5A | 11641791 | SIGNOR-111078 |
| JAK3 | phosphorylation up-regulates → | STAT5A PTyr694 | phosphorylation up-regulates → | STAT5A | 18250158 | SIGNOR-160672 |
| BTK | phosphorylation up-regulates → | STAT5A PTyr694 | phosphorylation up-regulates → | STAT5A | 11413148 | SIGNOR-250603 |
| PTPRG | dephosphorylation down-regulates ⊣ | STAT5A PTyr694 | dephosphorylation down-regulates ⊣ | STAT5A | 25624455 | SIGNOR-254730 |
| MAPK1 | phosphorylation up-regulates → | STAT5A PSer780 | phosphorylation up-regulates → | STAT5A | 10194762 | SIGNOR-66239 |
| FLT3 | phosphorylation up-regulates → | STAT5A PTyr694 | phosphorylation up-regulates → | STAT5A | 17356133 | SIGNOR-245069 |
| JAK3 | phosphorylation up-regulates → | STAT5A PTyr694 | phosphorylation up-regulates → | STAT5A | 19088846 | SIGNOR-182817 |
| ERBB4 | phosphorylation up-regulates → | STAT5A PTyr694 | phosphorylation up-regulates → | STAT5A | 15863494 | SIGNOR-279711 |
| PTPN1 | dephosphorylation down-regulates ⊣ | STAT5A PTyr694 | dephosphorylation up-regulates → | STAT5A | 10993888 | SIGNOR-248428 |
| MAPK3 | phosphorylation up-regulates → | STAT5A PSer780 | phosphorylation up-regulates → | STAT5A | 10194762 | SIGNOR-66247 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| JAK2 | phosphorylation → up-regulates | STAT5A | SIGNOR-56827 |
| SRC | phosphorylation → up-regulates | STAT5A | SIGNOR-111078 |
| JAK3 | phosphorylation → up-regulates | STAT5A | SIGNOR-160672 |
| PTEN | dephosphorylation down-regulates | STAT5A | SIGNOR-166481 |
| Gbeta | phosphorylation → up-regulates | STAT5A | SIGNOR-270004 |
| ERK1/2 | phosphorylation → up-regulates | STAT5A | SIGNOR-270136 |
| BTK | phosphorylation → up-regulates activity | STAT5A | SIGNOR-250603 |
| FLT3 | phosphorylation → up-regulates activity | STAT5A | SIGNOR-261516 |
| PTPRG | dephosphorylation → up-regulates activity | STAT5A | SIGNOR-254730 |
| PTPN2 | dephosphorylation → down-regulates activity | STAT5A | SIGNOR-133547 |
| MAPK1 | phosphorylation → up-regulates | STAT5A | SIGNOR-66239 |
| BCR-ABL | phosphorylation → up-regulates activity | STAT5A | SIGNOR-255813 |
| FLT3 | phosphorylation → up-regulates activity | STAT5A | SIGNOR-245069 |
| JAK2 | phosphorylation → up-regulates activity | STAT5A | SIGNOR-249507 |
| JAK3 | phosphorylation → up-regulates | STAT5A | SIGNOR-182817 |
| ERBB4 | phosphorylation → up-regulates activity | STAT5A | SIGNOR-279711 |
| PTPN1 | dephosphorylation → down-regulates activity | STAT5A | SIGNOR-248428 |
| MAPK3 | phosphorylation → up-regulates | STAT5A | SIGNOR-66247 |