| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| BTK | STAT5A | Tyr694 | LAKAVDGyVKPQIKQ | phosphorylation up-regulates activity | 11413148 | SIGNOR-250603 |
| JAK2 | STAT5A | Tyr694 | LAKAVDGyVKPQIKQ | phosphorylation up-regulates | 9575217 | SIGNOR-56827 |
| JAK3 | STAT5A | Tyr694 | LAKAVDGyVKPQIKQ | phosphorylation up-regulates | 18250158 | SIGNOR-160672 |
| SRC | STAT5A | Tyr694 | LAKAVDGyVKPQIKQ | phosphorylation up-regulates | 11641791 | SIGNOR-111078 |
| ERBB4 | STAT5A | Tyr694 | LAKAVDGyVKPQIKQ | phosphorylation up-regulates activity | 15863494 | SIGNOR-279711 |
| FLT3 | STAT5A | Tyr694 | LAKAVDGyVKPQIKQ | phosphorylation up-regulates activity | 17356133 | SIGNOR-245069 |
| JAK3 | STAT5A | Tyr694 | LAKAVDGyVKPQIKQ | phosphorylation up-regulates | 19088846 | SIGNOR-182817 |
| PTPN1 | STAT5A | Tyr694 | LAKAVDGyVKPQIKQ | dephosphorylation down-regulates activity | 10993888 | SIGNOR-248428 |
| PTPRG | STAT5A | Tyr694 | LAKAVDGyVKPQIKQ | dephosphorylation up-regulates activity | 25624455 | SIGNOR-254730 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| BTK | phosphorylation up-regulates → | STAT5A PTyr694 | phosphorylation up-regulates → | STAT5A | 11413148 | SIGNOR-250603 |
| JAK2 | phosphorylation up-regulates → | STAT5A PTyr694 | phosphorylation up-regulates → | STAT5A | 9575217 | SIGNOR-56827 |
| JAK3 | phosphorylation up-regulates → | STAT5A PTyr694 | phosphorylation up-regulates → | STAT5A | 18250158 | SIGNOR-160672 |
| SRC | phosphorylation up-regulates → | STAT5A PTyr694 | phosphorylation up-regulates → | STAT5A | 11641791 | SIGNOR-111078 |
| ERBB4 | phosphorylation up-regulates → | STAT5A PTyr694 | phosphorylation up-regulates → | STAT5A | 15863494 | SIGNOR-279711 |
| FLT3 | phosphorylation up-regulates → | STAT5A PTyr694 | phosphorylation up-regulates → | STAT5A | 17356133 | SIGNOR-245069 |
| JAK3 | phosphorylation up-regulates → | STAT5A PTyr694 | phosphorylation up-regulates → | STAT5A | 19088846 | SIGNOR-182817 |
| PTPN1 | dephosphorylation down-regulates ⊣ | STAT5A PTyr694 | dephosphorylation up-regulates → | STAT5A | 10993888 | SIGNOR-248428 |
| PTPRG | dephosphorylation down-regulates ⊣ | STAT5A PTyr694 | dephosphorylation down-regulates ⊣ | STAT5A | 25624455 | SIGNOR-254730 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| BTK | phosphorylation → up-regulates activity | STAT5A | SIGNOR-250603 |
| JAK2 | phosphorylation → up-regulates | STAT5A | SIGNOR-56827 |
| JAK3 | phosphorylation → up-regulates | STAT5A | SIGNOR-160672 |
| SRC | phosphorylation → up-regulates | STAT5A | SIGNOR-111078 |
| ERBB4 | phosphorylation → up-regulates activity | STAT5A | SIGNOR-279711 |
| FLT3 | phosphorylation → up-regulates activity | STAT5A | SIGNOR-245069 |
| JAK3 | phosphorylation → up-regulates | STAT5A | SIGNOR-182817 |
| PTPN1 | dephosphorylation → down-regulates activity | STAT5A | SIGNOR-248428 |
| PTPRG | dephosphorylation → up-regulates activity | STAT5A | SIGNOR-254730 |
