Entity Details

Name PIK3CA
ID P42336
Role kinase
Enzymatic Domains
PI3K-ABD 16-105
PROSITE-ProRule
PI3K-RBD 187-289
PROSITE-ProRule
C2 PI3K-type 330-487
PROSITE-ProRule
PIK helical 517-694
PROSITE-ProRule
PI3K/PI4K catalytic 765-1051
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PIK3CATPM1Ser61EDELDKYsEALKDAQphosphorylation
up-regulates activity		16094730SIGNOR-263027
PIK3CAPIK3R1Ser608ENTEDQYsLVEDDEDphosphorylation
up-regulates activity		14729945SIGNOR-276004
PIK3CABTK–phosphorylation
up-regulates activity		10201980SIGNOR-249610
PIK3CAAKT–phosphorylation
up-regulates activity		12167717SIGNOR-244429
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PIK3CAphosphorylation
up-regulates
→
TPM1
PSer61		phosphorylation
up-regulates
→		TPM116094730SIGNOR-263027
PIK3CAphosphorylation
up-regulates
→
PIK3R1
PSer608		phosphorylation
up-regulates
→		PIK3R114729945SIGNOR-276004
Regulator Mechanism/Effect Target SIGNOR-ID
PIK3CAphosphorylation
→
up-regulates activity 		TPM1SIGNOR-263027
PIK3CAphosphorylation
→
up-regulates activity 		PIK3R1SIGNOR-276004
PIK3CAphosphorylation
→
up-regulates activity 		BTKSIGNOR-249610
PIK3CAphosphorylation
→
up-regulates activity 		AKTSIGNOR-244429