Summary

Name PIK3CA
Full Name Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Synonyms PI3-kinase subunit alpha, PI3K-alpha, PI3Kalpha, PtdIns-3-kinase subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha, PtdIns-3-kinase subunit p110-alpha, p110alpha, Phosphoinositide-3-kinase catalytic alpha polypeptide, Serine/threonine protein kinase PIK3CA, 2.7.11.1
Primary ID P42336
Links - -
Type protein
Relations 64
Pathways AMPK Signaling, EGFR, Glioblastoma Multiforme, Malignant Melanoma, Acute Myeloid Leukemia, IGF and Myogenesis, Colorectal Carcinoma, Luminal Breast Cancer, Prostate Cancer, Rhabdomyosarcoma, MTOR Signaling, mTOR cancer
Inhibitors PIK-293; wortmannin; GDC-0941; GSK1059615; ZSTK474; GSK2126458; PKI-587; PI-103; PIK-90; PKI-402; 944396-07-0; GDC-0980; 1166227-08-2; XL147; XL765; CUDC-907; 915019-65-7; CH5132799; D-106669; PIK-75 Hydrochloride; PP121
Function Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation through the PDPK1-AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. Also has serine-protein kinase activity

Viewer

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding PIK3CA 0.78
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:Glioblastoma Multiforme, MTOR Signaling, IGF and Myogenesis
+ down-regulates img/direct_inhibition.png chemical inhibition PIK3CA
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png unknown PIK3CA 0.03
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png chemical inhibition PIK3CA
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PIK3CA 0.29
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PIK3CA 0.05
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown RAC1 0.20
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PIK3CA
Publications: 1 Organism: Homo Sapiens
Tissue: Breast
+ up-regulates img/direct-activation.png binding PIK3CA 0.07
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PIK3CA 0.15
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PIK3CA 0.07
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation BTK 0.18
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding PIK3CA 0.25
Publications: 1 Organism: Homo Sapiens
Pathways:Colorectal Carcinoma
+ up-regulates img/direct-activation.png binding PIK3CA 0.07
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PIK3CA 0.40
Publications: 1 Organism: Homo Sapiens
Tissue: Lung Cancer Cell
Pathways:AMPK Signaling, Luminal Breast Cancer, mTOR cancer, MTOR Signaling, IGF and Myogenesis
+ up-regulates activity img/indirect-activation.png unknown AKT1
Publications: 4 Organism: Homo Sapiens
Tissue: Breast Cancer Cell, Colonic Cancer Cell
Pathways:Glioblastoma Multiforme, IGF and Myogenesis
+ up-regulates img/direct-activation.png binding PIK3CA
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR, Rhabdomyosarcoma
+ up-regulates quantity img/direct-activation.png small molecule catalysis PtsIns(3,4,5)P3
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, AMPK Signaling, EGFR, Glioblastoma Multiforme, Luminal Breast Cancer, Malignant Melanoma, MTOR Signaling, IGF and Myogenesis, Prostate Cancer, Rhabdomyosarcoma
+ down-regulates img/direct_inhibition.png chemical inhibition PIK3CA
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png unknown PIK3CA
Publications: 1 Organism: Homo Sapiens
Pathways:Colorectal Carcinoma, Glioblastoma Multiforme, Luminal Breast Cancer, Malignant Melanoma, MTOR Signaling, Prostate Cancer
+ up-regulates img/direct-activation.png binding PIK3CA
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, Colorectal Carcinoma, Glioblastoma Multiforme, Luminal Breast Cancer, Rhabdomyosarcoma
+ up-regulates activity img/direct-activation.png binding PIK3CA 0.42
Publications: 1 Organism: Homo Sapiens
Pathways:Malignant Melanoma
+ up-regulates img/indirect-activation.png unknown AKT2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png unknown IRS1
Publications: 1 Organism: Homo Sapiens
Pathways:AMPK Signaling, Luminal Breast Cancer, mTOR cancer, MTOR Signaling, IGF and Myogenesis
+ down-regulates img/direct_inhibition.png chemical inhibition PIK3CA
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation AKT
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, AMPK Signaling, EGFR, Luminal Breast Cancer, mTOR cancer, Malignant Melanoma, MTOR Signaling, Prostate Cancer, Rhabdomyosarcoma
+ up-regulates activity img/indirect-activation.png unknown AKT
Publications: 1 Organism: Homo Sapiens
Tissue: Breast Cancer Cell
Pathways:Acute Myeloid Leukemia, AMPK Signaling, EGFR, Luminal Breast Cancer, mTOR cancer, Malignant Melanoma, MTOR Signaling, Prostate Cancer, Rhabdomyosarcoma
+ down-regulates img/direct_inhibition.png chemical inhibition PIK3CA
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PIK3CA
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PIK3CA
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PIK3CA 0.19
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding PIK3CA 0.05
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding PI3K
Publications: 1 Organism: Homo Sapiens
Pathways:mTOR cancer
+ down-regulates img/direct_inhibition.png chemical inhibition PIK3CA
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PIK3CA
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PIK3CA
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PIK3CA
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown MTOR 0.56
Publications: 1 Organism: Homo Sapiens
Pathways:Glioblastoma Multiforme, MTOR Signaling
+ down-regulates img/direct_inhibition.png chemical inhibition PIK3CA
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PIK3CA
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PIK3CA
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PIK3CA
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PIK3CA
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PIK3CA
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown Survival
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:Colorectal Carcinoma, Glioblastoma Multiforme, Luminal Breast Cancer, Malignant Melanoma, Prostate Cancer, Rhabdomyosarcoma
+ up-regulates img/direct-activation.png binding PIK3CA 0.13
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PIK3CA 0.07
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PIK3CA
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR
+ up-regulates activity img/direct-activation.png binding PIK3CA
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:EGFR
+ up-regulates img/direct-activation.png binding PIK3CA
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PIK3CA
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PIK3CA
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PIK3CA
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PIK3CA
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PIK3CA
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PIK3CA
Publications: 1 Organism: Homo Sapiens