Entity Details

Name PIK3CA
ID P42336
Role substrate
Enzymatic Domains
PI3K-ABD 16-105
PROSITE-ProRule
PI3K-RBD 187-289
PROSITE-ProRule
C2 PI3K-type 330-487
PROSITE-ProRule
PIK helical 517-694
PROSITE-ProRule
PI3K/PI4K catalytic 765-1051
PROSITE-ProRule
View in

Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
MAP4K4PIK3CAThr1061KMDWIFHtIKQHALNphosphorylation
down-regulates activity		38060450SIGNOR-277921
STK4PIK3CAThr1061KMDWIFHtIKQHALNphosphorylation
down-regulates activity		38060450SIGNOR-277920
STK3PIK3CAThr1061KMDWIFHtIKQHALNphosphorylation
down-regulates activity		38060450SIGNOR-277922
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
MAP4K4phosphorylation
up-regulates
→
PIK3CA
PThr1061		phosphorylation
down-regulates
⊣		PIK3CA38060450SIGNOR-277921
STK4phosphorylation
up-regulates
→
PIK3CA
PThr1061		phosphorylation
down-regulates
⊣		PIK3CA38060450SIGNOR-277920
STK3phosphorylation
up-regulates
→
PIK3CA
PThr1061		phosphorylation
down-regulates
⊣		PIK3CA38060450SIGNOR-277922
Regulator Mechanism/Effect Target SIGNOR-ID
MAP4K4phosphorylation
→
down-regulates activity 		PIK3CASIGNOR-277921
STK4phosphorylation
→
down-regulates activity 		PIK3CASIGNOR-277920
STK3phosphorylation
→
down-regulates activity 		PIK3CASIGNOR-277922