| Name | MTOR |
| ID | P42345 |
| Role | kinase |
| Enzymatic Domains |
FAT 1382-1982 PROSITE-ProRule
PI3K/PI4K catalytic 2156-2469 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MTOR | TFEB | Ser211 | LVGVTSSsCPADLTQ | phosphorylation down-regulates activity | 22692423 | SIGNOR-248270 |
| MTOR | IRS1 | Ser307 | TRRSRTEsITATSPA | phosphorylation down-regulates activity | 11287630 | SIGNOR-106570 |
| MTOR | EIF4EBP1 | Thr36 | LPPGDYStTPGGTLF | phosphorylation down-regulates activity | 20670887 | SIGNOR-167180 |
| MTOR | AKT1S1 | Ser183 | PTQQYAKsLPVSVPV | phosphorylation down-regulates activity | 17517883 | SIGNOR-154956 |
| MTOR | DEPTOR | Ser299 | SSPTLSSsPPVLCNP | phosphorylation down-regulates | 22017875 | SIGNOR-176853 |
| MTOR | RPTOR | Ser855 | QRVLDTSsLTQSAPA | phosphorylation up-regulates activity | 19864431 | SIGNOR-174882 |
| MTOR | TFEB | Ser142 | AGNSAPNsPMAMLHI | phosphorylation down-regulates activity | 22343943 | SIGNOR-255310 |
| MTOR | RPS6KB1 | Thr390 | DSKFTRQtPVDSPDD | phosphorylation up-regulates activity | 11914378 | SIGNOR-255839 |
| MTOR | AKT1 | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates activity | 21592956 | SIGNOR-217869 |
| MTOR | RPS6K | Thr390 | DSKFTRQtPVDSPDD | phosphorylation up-regulates activity | 11914378 | SIGNOR-255841 |
| MTOR | IGF1R | – | phosphorylation up-regulates activity | 26584640 | SIGNOR-280044 | |
| MTOR | INSR | – | phosphorylation up-regulates activity | 26584640 | SIGNOR-280045 | |
| MTOR | IGF2BP2 | – | phosphorylation up-regulates activity | 29736175 | SIGNOR-280046 | |
| MTOR | SIRT1 | Ser47 | DGPGLERsPGEPGGA | phosphorylation down-regulates activity | 21471201 | SIGNOR-280047 |
| MTOR | EIF4EBP1 | Thr70 | RNSPVTKtPPRDLPT | phosphorylation down-regulates activity | 10942774 | SIGNOR-226710 |
| MTOR | GRB10 | – | phosphorylation up-regulates | 21659604 | SIGNOR-174071 | |
| MTOR | AMBRA1 | Ser52 | KRVELPDsPRSTFLL | phosphorylation down-regulates activity | 23524951 | SIGNOR-272986 |
| MTOR | MAF1 | Ser68 | PPQTSGLsPSRLSKS | phosphorylation down-regulates | 20233713 | SIGNOR-164348 |
| MTOR | LARP6 | Ser409 | GRLNCSTsPEIFRKC | phosphorylation up-regulates activity | 28112218 | SIGNOR-273678 |
| MTOR | AKT1S1 | Ser212 | EENGPPSsPDLDRIA | phosphorylation down-regulates activity | 18372248 | SIGNOR-178124 |
| MTOR | EIF4EBP1 | Ser65 | FLMECRNsPVTKTPP | phosphorylation down-regulates activity | 23486913 | SIGNOR-219257 |
| MTOR | RPTOR | Ser859 | DTSSLTQsAPASPTN | phosphorylation up-regulates activity | 19864431 | SIGNOR-188920 |
| MTOR | IRS1 | Ser636 | SGDYMPMsPKSVSAP | phosphorylation down-regulates activity | 11287630 | SIGNOR-106586 |
| MTOR | IRS1 | Ser616 | DDGYMPMsPGVAPVP | phosphorylation down-regulates activity | 11287630 | SIGNOR-106582 |
| MTOR | RPTOR | Ser863 | LTQSAPAsPTNKGVH | phosphorylation up-regulates activity | 19864431 | SIGNOR-188924 |
| MTOR | NRBF2 | Ser113 | AEDAEGQsPLSQKYS | phosphorylation up-regulates activity | 28059666 | SIGNOR-265874 |
| MTOR | MTOR | Ser2481 | TVPESIHsFIGDGLV | phosphorylation up-regulates activity | 20022946 | SIGNOR-235427 |
| MTOR | SGK1 | Ser422 | AEAFLGFsYAPPTDS | phosphorylation up-regulates | 18925875 | SIGNOR-181531 |
| MTOR | PRKN | Ser127 | AVILHTDsRKDSPPA | phosphorylation down-regulates activity | 35191952 | SIGNOR-277586 |
| MTOR | CLIP1 | – | phosphorylation up-regulates activity | 12742166 | SIGNOR-279231 | |
| MTOR | RPS6KA2 | – | phosphorylation up-regulates activity | 20602111 | SIGNOR-279232 | |
| MTOR | EIF4EBP1 | Thr70 | RNSPVTKtPPRDLPT | phosphorylation down-regulates activity | 23486913 | SIGNOR-219273 |
| MTOR | NRBF2 | Ser120 | SPLSQKYsPSTEKCL | phosphorylation up-regulates activity | 28059666 | SIGNOR-265875 |
| MTOR | ACLY | Ser455 | PAPSRTAsFSESRAD | phosphorylation up-regulates activity | 27015560 | SIGNOR-278962 |
| MTOR | AKT1S1 | Ser183 | PTQQYAKsLPVSVPV | phosphorylation down-regulates activity | 18372248 | SIGNOR-178120 |
| MTOR | MKNK2 | Ser74 | KRGRATDsFSGRFED | phosphorylation down-regulates activity | 32170339 | SIGNOR-277516 |
| MTOR | DAP | Ser3 | DQEWESPsPPKPTVF | phosphorylation down-regulates activity | 20537536 | SIGNOR-259813 |
| MTOR | AKT1 | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates activity | 15718470 | SIGNOR-252599 |
| MTOR | EIF4EBP1 | Thr70 | RNSPVTKtPPRDLPT | phosphorylation down-regulates activity | 12747827 | SIGNOR-101127 |
| MTOR | EIF4EBP1 | Thr37 | PPGDYSTtPGGTLFS | phosphorylation down-regulates activity | 12747827 | SIGNOR-101119 |
| MTOR | RPS6KB2 | – | phosphorylation up-regulates | 17510057 | SIGNOR-154821 | |
| MTOR | AKT | – | phosphorylation up-regulates activity | 21592956 | SIGNOR-244417 | |
| MTOR | RPS6KB2 | – | phosphorylation up-regulates | 23486913 | SIGNOR-201541 | |
| MTOR | EIF4EBP1 | Thr46 | GGTLFSTtPGGTRII | phosphorylation down-regulates activity | 12747827 | SIGNOR-101123 |
| MTOR | LARP6 | Ser348 | DPESNPTsPMAGRRH | phosphorylation up-regulates activity | 28112218 | SIGNOR-273679 |
| MTOR | RPS6KB1 | Ser394 | TRQTPVDsPDDSTLS | phosphorylation up-regulates activity | 23486913 | SIGNOR-201530 |
| MTOR | EIF4EBP1 | Thr45 | PGGTLFStTPGGTRI | phosphorylation down-regulates activity | 9465032 | SIGNOR-55701 |
| MTOR | MAF1 | Ser60 | PHVLEALsPPQTSGL | phosphorylation down-regulates | 20516213 | SIGNOR-165791 |
| MTOR | MTOR | Ser2481 | TVPESIHsFIGDGLV | phosphorylation up-regulates activity | 10702316 | SIGNOR-75394 |
| MTOR | IRS1 | Ser639 | YMPMSPKsVSAPQQI | phosphorylation down-regulates activity | 11287630 | SIGNOR-106590 |
| MTOR | EIF4E | – | phosphorylation down-regulates activity | 35697076 | SIGNOR-278963 | |
| MTOR | EIF4EBP1 | Ser65 | FLMECRNsPVTKTPP | phosphorylation down-regulates activity | 10942774 | SIGNOR-226714 |
| MTOR | EIF4EBP1 | Thr36 | LPPGDYStTPGGTLF | phosphorylation down-regulates activity | 9465032 | SIGNOR-55697 |
| MTOR | IRS1 | Ser315 | ITATSPAsMVGGKPG | phosphorylation down-regulates activity | 11287630 | SIGNOR-106578 |
| MTOR | ULK1 | – | phosphorylation down-regulates activity | 21460634 | SIGNOR-183903 | |
| MTOR | EIF4EBP1 | Ser83 | PTIPGVTsPSSDEPP | phosphorylation down-regulates activity | 9204908 | SIGNOR-250292 |
| MTOR | RPS6KB1 | Ser434 | SFEPKIRsPRRFIGS | phosphorylation up-regulates activity | 23486913 | SIGNOR-201534 |
| MTOR | DEPTOR | Ser293 | SSGYFSSsPTLSSSP | phosphorylation down-regulates | 22017875 | SIGNOR-176849 |
| MTOR | AKT1S1 | Ser221 | DLDRIAAsMRALVLR | phosphorylation down-regulates activity | 18372248 | SIGNOR-178128 |
| MTOR | AMOTL2 | Ser759 | SSSQRAAsLDSVATS | phosphorylation down-regulates activity | 25998128 | SIGNOR-272086 |
| MTOR | EIF4EBP1 | Thr46 | GGTLFSTtPGGTRII | phosphorylation down-regulates activity | 23486913 | SIGNOR-219266 |
| MTOR | RPTOR | Ser859 | DTSSLTQsAPASPTN | phosphorylation up-regulates activity | 19346248 | SIGNOR-184959 |
| MTOR | RPS6KB1 | Thr412 | NQVFLGFtYVAPSVL | phosphorylation up-regulates activity | 12782654 | SIGNOR-101336 |
| MTOR | STAT3 | Ser727 | NTIDLPMsPRTLDSL | phosphorylation up-regulates | 16740698 | SIGNOR-146915 |
| MTOR | ESR1 | – | phosphorylation up-regulates activity | 26522726 | SIGNOR-278295 | |
| MTOR | ELP1 | Ser1174 | SETSSVVsGSEMSGK | phosphorylation up-regulates activity | 29925953 | SIGNOR-275541 |
| MTOR | RPS6KB2 | Thr228 | HEGAVTHtFCGTIEY | phosphorylation up-regulates activity | 11733037 | SIGNOR-250294 |
| MTOR | AKT | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates activity | 15718470 | SIGNOR-134185 |
| MTOR | SGK1 | Ser422 | AEAFLGFsYAPPTDS | phosphorylation up-regulates | 18570873 | SIGNOR-179113 |
| MTOR | IRS1 | Ser307 | TRRSRTEsITATSPA | phosphorylation down-regulates activity | 9335553 | SIGNOR-52700 |
| MTOR | ULK2 | – | phosphorylation down-regulates | 19211836 | SIGNOR-183961 | |
| MTOR | EIF4EBP1 | Ser65 | FLMECRNsPVTKTPP | phosphorylation down-regulates activity | 12747827 | SIGNOR-101115 |
| MTOR | RPS6KB1 | Thr412 | NQVFLGFtYVAPSVL | phosphorylation up-regulates activity | 10579915 | SIGNOR-72682 |
| MTOR | EIF4EBP2 | – | phosphorylation down-regulates | 14967450 | SIGNOR-122014 | |
| MTOR | EIF4EBP1 | Thr37 | PPGDYSTtPGGTLFS | phosphorylation down-regulates activity | 23486913 | SIGNOR-219262 |
| MTOR | AKT1 | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates activity | 21157483 | SIGNOR-170604 |
| MTOR | STAT3 | Ser727 | NTIDLPMsPRTLDSL | phosphorylation up-regulates | 18691976 | SIGNOR-161439 |
| MTOR | RPS6KB1 | Thr412 | NQVFLGFtYVAPSVL | phosphorylation up-regulates activity | 23486913 | SIGNOR-201538 |
| MTOR | UVRAG | Ser571 | KGEDLVGsLNGGHAN | phosphorylation up-regulates activity | 26139536 | SIGNOR-276919 |
| MTOR | RPS6KB2 | Thr388 | NQAFLGFtYVAPSVL | phosphorylation up-regulates activity | 11733037 | SIGNOR-250295 |
| MTOR | MAF1 | Ser68 | PPQTSGLsPSRLSKS | phosphorylation down-regulates | 20516213 | SIGNOR-165795 |
| MTOR | ISCU | Ser14 | FRLRRAAsALLLRSP | phosphorylation up-regulates | 23508953 | SIGNOR-201595 |
| MTOR | RPS6KB1 | Thr412 | NQVFLGFtYVAPSVL | phosphorylation up-regulates activity | 17510057 | SIGNOR-235507 |
| MTOR | EIF4EBP1 | Thr45 | PGGTLFStTPGGTRI | phosphorylation down-regulates activity | 17510057 | SIGNOR-154814 |
| MTOR | EIF4EBP1 | Thr70 | RNSPVTKtPPRDLPT | phosphorylation down-regulates activity | 10942774 | SIGNOR-80797 |
| MTOR | ULK1 | Ser758 | PVVFTVGsPPSGSTP | phosphorylation down-regulates activity | 21383122 | SIGNOR-172541 |
| MTOR | RPS6KB2 | Ser370 | TRQTPVDsPDDTALS | phosphorylation up-regulates activity | 11733037 | SIGNOR-250293 |
| MTOR | EIF4EBP1 | Thr45 | PGGTLFStTPGGTRI | phosphorylation down-regulates activity | 20670887 | SIGNOR-167184 |
| MTOR | MAF1 | Ser75 | SPSRLSKsQGGEEEG | phosphorylation down-regulates | 20516213 | SIGNOR-165799 |
| MTOR | RPS6KB1 | Ser434 | SFEPKIRsPRRFIGS | phosphorylation up-regulates activity | 12782654 | SIGNOR-101332 |
| MTOR | DNM1L | Ser616 | PIPIMPAsPQKGHAV | phosphorylation up-regulates activity | 34535949 | SIGNOR-275430 |
| MTOR | DAP | Ser51 | DQEWESPsPPKPTVF | phosphorylation down-regulates activity | 20537536 | SIGNOR-259812 |
| MTOR | UVRAG | Ser550 | KITSLSSsLDTSLDF | phosphorylation up-regulates activity | 26139536 | SIGNOR-276920 |
| MTOR | RPS6KB1 | Thr412 | NQVFLGFtYVAPSVL | phosphorylation up-regulates activity | 10567431 | SIGNOR-72357 |
| MTOR | EIF4EBP2 | – | phosphorylation down-regulates | 23100465 | SIGNOR-199258 | |
| MTOR | ULK1 | – | phosphorylation down-regulates activity | 19690328 | SIGNOR-187611 | |
| MTOR | RPS6KB1 | Ser394 | TRQTPVDsPDDSTLS | phosphorylation up-regulates activity | 12782654 | SIGNOR-101328 |
| MTOR | EIF4EBP3 | – | phosphorylation up-regulates | 14967450 | SIGNOR-122035 | |
| MTOR | ATG13 | – | phosphorylation down-regulates | 19211837 | SIGNOR-183965 | |
| MTOR | MAF1 | Ser75 | SPSRLSKsQGGEEEG | phosphorylation down-regulates | 20543138 | SIGNOR-166054 |
| MTOR | MAF1 | Ser75 | SPSRLSKsQGGEEEG | phosphorylation down-regulates | 20233713 | SIGNOR-164352 |
| MTOR | IRS1 | Ser312 | TESITATsPASMVGG | phosphorylation down-regulates activity | 11287630 | SIGNOR-106574 |
| MTOR | EIF4EBP1 | Thr36 | LPPGDYStTPGGTLF | phosphorylation down-regulates activity | 17510057 | SIGNOR-154810 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MTOR | phosphorylation up-regulates → | TFEB PSer211 | phosphorylation down-regulates ⊣ | TFEB | 22692423 | SIGNOR-248270 |
| MTOR | phosphorylation up-regulates → | IRS1 PSer307 | phosphorylation down-regulates ⊣ | IRS1 | 11287630 | SIGNOR-106570 |
| MTOR | phosphorylation up-regulates → | EIF4EBP1 PThr36 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 20670887 | SIGNOR-167180 |
| MTOR | phosphorylation up-regulates → | AKT1S1 PSer183 | phosphorylation down-regulates ⊣ | AKT1S1 | 17517883 | SIGNOR-154956 |
| MTOR | phosphorylation up-regulates → | DEPTOR PSer299 | phosphorylation down-regulates ⊣ | DEPTOR | 22017875 | SIGNOR-176853 |
| MTOR | phosphorylation up-regulates → | RPTOR PSer855 | phosphorylation up-regulates → | RPTOR | 19864431 | SIGNOR-174882 |
| MTOR | phosphorylation up-regulates → | TFEB PSer142 | phosphorylation down-regulates ⊣ | TFEB | 22343943 | SIGNOR-255310 |
| MTOR | phosphorylation up-regulates → | RPS6KB1 PThr390 | phosphorylation up-regulates → | RPS6KB1 | 11914378 | SIGNOR-255839 |
| MTOR | phosphorylation up-regulates → | AKT1 PSer473 | phosphorylation up-regulates → | AKT1 | 21592956 | SIGNOR-217869 |
| MTOR | phosphorylation up-regulates → | RPS6K PThr390 | phosphorylation up-regulates → | RPS6K | 11914378 | SIGNOR-255841 |
| MTOR | phosphorylation up-regulates → | SIRT1 PSer47 | phosphorylation down-regulates ⊣ | SIRT1 | 21471201 | SIGNOR-280047 |
| MTOR | phosphorylation up-regulates → | EIF4EBP1 PThr70 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 10942774 | SIGNOR-226710 |
| MTOR | phosphorylation up-regulates → | AMBRA1 PSer52 | phosphorylation down-regulates ⊣ | AMBRA1 | 23524951 | SIGNOR-272986 |
| MTOR | phosphorylation up-regulates → | MAF1 PSer68 | phosphorylation down-regulates ⊣ | MAF1 | 20233713 | SIGNOR-164348 |
| MTOR | phosphorylation up-regulates → | LARP6 PSer409 | phosphorylation up-regulates → | LARP6 | 28112218 | SIGNOR-273678 |
| MTOR | phosphorylation up-regulates → | AKT1S1 PSer212 | phosphorylation down-regulates ⊣ | AKT1S1 | 18372248 | SIGNOR-178124 |
| MTOR | phosphorylation up-regulates → | EIF4EBP1 PSer65 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 23486913 | SIGNOR-219257 |
| MTOR | phosphorylation up-regulates → | RPTOR PSer859 | phosphorylation up-regulates → | RPTOR | 19864431 | SIGNOR-188920 |
| MTOR | phosphorylation up-regulates → | IRS1 PSer636 | phosphorylation down-regulates ⊣ | IRS1 | 11287630 | SIGNOR-106586 |
| MTOR | phosphorylation up-regulates → | IRS1 PSer616 | phosphorylation down-regulates ⊣ | IRS1 | 11287630 | SIGNOR-106582 |
| MTOR | phosphorylation up-regulates → | RPTOR PSer863 | phosphorylation up-regulates → | RPTOR | 19864431 | SIGNOR-188924 |
| MTOR | phosphorylation up-regulates → | NRBF2 PSer113 | phosphorylation up-regulates → | NRBF2 | 28059666 | SIGNOR-265874 |
| MTOR | phosphorylation up-regulates → | MTOR PSer2481 | phosphorylation up-regulates → | MTOR | 20022946 | SIGNOR-235427 |
| MTOR | phosphorylation up-regulates → | SGK1 PSer422 | phosphorylation up-regulates → | SGK1 | 18925875 | SIGNOR-181531 |
| MTOR | phosphorylation up-regulates → | PRKN PSer127 | phosphorylation down-regulates ⊣ | PRKN | 35191952 | SIGNOR-277586 |
| MTOR | phosphorylation up-regulates → | EIF4EBP1 PThr70 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 23486913 | SIGNOR-219273 |
| MTOR | phosphorylation up-regulates → | NRBF2 PSer120 | phosphorylation up-regulates → | NRBF2 | 28059666 | SIGNOR-265875 |
| MTOR | phosphorylation up-regulates → | ACLY PSer455 | phosphorylation up-regulates → | ACLY | 27015560 | SIGNOR-278962 |
| MTOR | phosphorylation up-regulates → | AKT1S1 PSer183 | phosphorylation down-regulates ⊣ | AKT1S1 | 18372248 | SIGNOR-178120 |
| MTOR | phosphorylation up-regulates → | MKNK2 PSer74 | phosphorylation down-regulates ⊣ | MKNK2 | 32170339 | SIGNOR-277516 |
| MTOR | phosphorylation up-regulates → | DAP PSer3 | phosphorylation down-regulates ⊣ | DAP | 20537536 | SIGNOR-259813 |
| MTOR | phosphorylation up-regulates → | AKT1 PSer473 | phosphorylation up-regulates → | AKT1 | 15718470 | SIGNOR-252599 |
| MTOR | phosphorylation up-regulates → | EIF4EBP1 PThr70 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 12747827 | SIGNOR-101127 |
| MTOR | phosphorylation up-regulates → | EIF4EBP1 PThr37 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 12747827 | SIGNOR-101119 |
| MTOR | phosphorylation up-regulates → | EIF4EBP1 PThr46 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 12747827 | SIGNOR-101123 |
| MTOR | phosphorylation up-regulates → | LARP6 PSer348 | phosphorylation up-regulates → | LARP6 | 28112218 | SIGNOR-273679 |
| MTOR | phosphorylation up-regulates → | RPS6KB1 PSer394 | phosphorylation up-regulates → | RPS6KB1 | 23486913 | SIGNOR-201530 |
| MTOR | phosphorylation up-regulates → | EIF4EBP1 PThr45 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 9465032 | SIGNOR-55701 |
| MTOR | phosphorylation up-regulates → | MAF1 PSer60 | phosphorylation down-regulates ⊣ | MAF1 | 20516213 | SIGNOR-165791 |
| MTOR | phosphorylation up-regulates → | MTOR PSer2481 | phosphorylation up-regulates → | MTOR | 10702316 | SIGNOR-75394 |
| MTOR | phosphorylation up-regulates → | IRS1 PSer639 | phosphorylation down-regulates ⊣ | IRS1 | 11287630 | SIGNOR-106590 |
| MTOR | phosphorylation up-regulates → | EIF4EBP1 PSer65 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 10942774 | SIGNOR-226714 |
| MTOR | phosphorylation up-regulates → | EIF4EBP1 PThr36 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 9465032 | SIGNOR-55697 |
| MTOR | phosphorylation up-regulates → | IRS1 PSer315 | phosphorylation down-regulates ⊣ | IRS1 | 11287630 | SIGNOR-106578 |
| MTOR | phosphorylation up-regulates → | EIF4EBP1 PSer83 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 9204908 | SIGNOR-250292 |
| MTOR | phosphorylation up-regulates → | RPS6KB1 PSer434 | phosphorylation up-regulates → | RPS6KB1 | 23486913 | SIGNOR-201534 |
| MTOR | phosphorylation up-regulates → | DEPTOR PSer293 | phosphorylation down-regulates ⊣ | DEPTOR | 22017875 | SIGNOR-176849 |
| MTOR | phosphorylation up-regulates → | AKT1S1 PSer221 | phosphorylation down-regulates ⊣ | AKT1S1 | 18372248 | SIGNOR-178128 |
| MTOR | phosphorylation up-regulates → | AMOTL2 PSer759 | phosphorylation down-regulates ⊣ | AMOTL2 | 25998128 | SIGNOR-272086 |
| MTOR | phosphorylation up-regulates → | EIF4EBP1 PThr46 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 23486913 | SIGNOR-219266 |
| MTOR | phosphorylation up-regulates → | RPTOR PSer859 | phosphorylation up-regulates → | RPTOR | 19346248 | SIGNOR-184959 |
| MTOR | phosphorylation up-regulates → | RPS6KB1 PThr412 | phosphorylation up-regulates → | RPS6KB1 | 12782654 | SIGNOR-101336 |
| MTOR | phosphorylation up-regulates → | STAT3 PSer727 | phosphorylation up-regulates → | STAT3 | 16740698 | SIGNOR-146915 |
| MTOR | phosphorylation up-regulates → | ELP1 PSer1174 | phosphorylation up-regulates → | ELP1 | 29925953 | SIGNOR-275541 |
| MTOR | phosphorylation up-regulates → | RPS6KB2 PThr228 | phosphorylation up-regulates → | RPS6KB2 | 11733037 | SIGNOR-250294 |
| MTOR | phosphorylation up-regulates → | AKT PSer473 | phosphorylation up-regulates → | AKT | 15718470 | SIGNOR-134185 |
| MTOR | phosphorylation up-regulates → | SGK1 PSer422 | phosphorylation up-regulates → | SGK1 | 18570873 | SIGNOR-179113 |
| MTOR | phosphorylation up-regulates → | IRS1 PSer307 | phosphorylation down-regulates ⊣ | IRS1 | 9335553 | SIGNOR-52700 |
| MTOR | phosphorylation up-regulates → | EIF4EBP1 PSer65 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 12747827 | SIGNOR-101115 |
| MTOR | phosphorylation up-regulates → | RPS6KB1 PThr412 | phosphorylation up-regulates → | RPS6KB1 | 10579915 | SIGNOR-72682 |
| MTOR | phosphorylation up-regulates → | EIF4EBP1 PThr37 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 23486913 | SIGNOR-219262 |
| MTOR | phosphorylation up-regulates → | AKT1 PSer473 | phosphorylation up-regulates → | AKT1 | 21157483 | SIGNOR-170604 |
| MTOR | phosphorylation up-regulates → | STAT3 PSer727 | phosphorylation up-regulates → | STAT3 | 18691976 | SIGNOR-161439 |
| MTOR | phosphorylation up-regulates → | RPS6KB1 PThr412 | phosphorylation up-regulates → | RPS6KB1 | 23486913 | SIGNOR-201538 |
| MTOR | phosphorylation up-regulates → | UVRAG PSer571 | phosphorylation up-regulates → | UVRAG | 26139536 | SIGNOR-276919 |
| MTOR | phosphorylation up-regulates → | RPS6KB2 PThr388 | phosphorylation up-regulates → | RPS6KB2 | 11733037 | SIGNOR-250295 |
| MTOR | phosphorylation up-regulates → | MAF1 PSer68 | phosphorylation down-regulates ⊣ | MAF1 | 20516213 | SIGNOR-165795 |
| MTOR | phosphorylation up-regulates → | ISCU PSer14 | phosphorylation up-regulates → | ISCU | 23508953 | SIGNOR-201595 |
| MTOR | phosphorylation up-regulates → | RPS6KB1 PThr412 | phosphorylation up-regulates → | RPS6KB1 | 17510057 | SIGNOR-235507 |
| MTOR | phosphorylation up-regulates → | EIF4EBP1 PThr45 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 17510057 | SIGNOR-154814 |
| MTOR | phosphorylation up-regulates → | EIF4EBP1 PThr70 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 10942774 | SIGNOR-80797 |
| MTOR | phosphorylation up-regulates → | ULK1 PSer758 | phosphorylation down-regulates ⊣ | ULK1 | 21383122 | SIGNOR-172541 |
| MTOR | phosphorylation up-regulates → | RPS6KB2 PSer370 | phosphorylation up-regulates → | RPS6KB2 | 11733037 | SIGNOR-250293 |
| MTOR | phosphorylation up-regulates → | EIF4EBP1 PThr45 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 20670887 | SIGNOR-167184 |
| MTOR | phosphorylation up-regulates → | MAF1 PSer75 | phosphorylation down-regulates ⊣ | MAF1 | 20516213 | SIGNOR-165799 |
| MTOR | phosphorylation up-regulates → | RPS6KB1 PSer434 | phosphorylation up-regulates → | RPS6KB1 | 12782654 | SIGNOR-101332 |
| MTOR | phosphorylation up-regulates → | DNM1L PSer616 | phosphorylation up-regulates → | DNM1L | 34535949 | SIGNOR-275430 |
| MTOR | phosphorylation up-regulates → | DAP PSer51 | phosphorylation down-regulates ⊣ | DAP | 20537536 | SIGNOR-259812 |
| MTOR | phosphorylation up-regulates → | UVRAG PSer550 | phosphorylation up-regulates → | UVRAG | 26139536 | SIGNOR-276920 |
| MTOR | phosphorylation up-regulates → | RPS6KB1 PThr412 | phosphorylation up-regulates → | RPS6KB1 | 10567431 | SIGNOR-72357 |
| MTOR | phosphorylation up-regulates → | RPS6KB1 PSer394 | phosphorylation up-regulates → | RPS6KB1 | 12782654 | SIGNOR-101328 |
| MTOR | phosphorylation up-regulates → | MAF1 PSer75 | phosphorylation down-regulates ⊣ | MAF1 | 20543138 | SIGNOR-166054 |
| MTOR | phosphorylation up-regulates → | MAF1 PSer75 | phosphorylation down-regulates ⊣ | MAF1 | 20233713 | SIGNOR-164352 |
| MTOR | phosphorylation up-regulates → | IRS1 PSer312 | phosphorylation down-regulates ⊣ | IRS1 | 11287630 | SIGNOR-106574 |
| MTOR | phosphorylation up-regulates → | EIF4EBP1 PThr36 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 17510057 | SIGNOR-154810 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MTOR | phosphorylation → down-regulates activity | TFEB | SIGNOR-248270 |
| MTOR | phosphorylation → down-regulates activity | IRS1 | SIGNOR-106570 |
| MTOR | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-167180 |
| MTOR | phosphorylation → down-regulates activity | AKT1S1 | SIGNOR-154956 |
| MTOR | phosphorylation down-regulates | DEPTOR | SIGNOR-176853 |
| MTOR | phosphorylation → up-regulates activity | RPTOR | SIGNOR-174882 |
| MTOR | phosphorylation → down-regulates activity | TFEB | SIGNOR-255310 |
| MTOR | phosphorylation → up-regulates activity | RPS6KB1 | SIGNOR-255839 |
| MTOR | phosphorylation → up-regulates activity | AKT1 | SIGNOR-217869 |
| MTOR | phosphorylation → up-regulates activity | RPS6K | SIGNOR-255841 |
| MTOR | phosphorylation → up-regulates activity | IGF1R | SIGNOR-280044 |
| MTOR | phosphorylation → up-regulates activity | INSR | SIGNOR-280045 |
| MTOR | phosphorylation → up-regulates activity | IGF2BP2 | SIGNOR-280046 |
| MTOR | phosphorylation → down-regulates activity | SIRT1 | SIGNOR-280047 |
| MTOR | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-226710 |
| MTOR | phosphorylation → up-regulates | GRB10 | SIGNOR-174071 |
| MTOR | phosphorylation → down-regulates activity | AMBRA1 | SIGNOR-272986 |
| MTOR | phosphorylation down-regulates | MAF1 | SIGNOR-164348 |
| MTOR | phosphorylation → up-regulates activity | LARP6 | SIGNOR-273678 |
| MTOR | phosphorylation → down-regulates activity | AKT1S1 | SIGNOR-178124 |
| MTOR | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-219257 |
| MTOR | phosphorylation → up-regulates activity | RPTOR | SIGNOR-188920 |
| MTOR | phosphorylation → down-regulates activity | IRS1 | SIGNOR-106586 |
| MTOR | phosphorylation → down-regulates activity | IRS1 | SIGNOR-106582 |
| MTOR | phosphorylation → up-regulates activity | RPTOR | SIGNOR-188924 |
| MTOR | phosphorylation → up-regulates activity | NRBF2 | SIGNOR-265874 |
| MTOR | phosphorylation → up-regulates activity | MTOR | SIGNOR-235427 |
| MTOR | phosphorylation → up-regulates | SGK1 | SIGNOR-181531 |
| MTOR | phosphorylation → down-regulates activity | PRKN | SIGNOR-277586 |
| MTOR | phosphorylation → up-regulates activity | CLIP1 | SIGNOR-279231 |
| MTOR | phosphorylation → up-regulates activity | RPS6KA2 | SIGNOR-279232 |
| MTOR | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-219273 |
| MTOR | phosphorylation → up-regulates activity | NRBF2 | SIGNOR-265875 |
| MTOR | phosphorylation → up-regulates activity | ACLY | SIGNOR-278962 |
| MTOR | phosphorylation → down-regulates activity | AKT1S1 | SIGNOR-178120 |
| MTOR | phosphorylation → down-regulates activity | MKNK2 | SIGNOR-277516 |
| MTOR | phosphorylation → down-regulates activity | DAP | SIGNOR-259813 |
| MTOR | phosphorylation → up-regulates activity | AKT1 | SIGNOR-252599 |
| MTOR | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-101127 |
| MTOR | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-101119 |
| MTOR | phosphorylation → up-regulates | RPS6KB2 | SIGNOR-154821 |
| MTOR | phosphorylation → up-regulates activity | AKT | SIGNOR-244417 |
| MTOR | phosphorylation → up-regulates | RPS6KB2 | SIGNOR-201541 |
| MTOR | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-101123 |
| MTOR | phosphorylation → up-regulates activity | LARP6 | SIGNOR-273679 |
| MTOR | phosphorylation → up-regulates activity | RPS6KB1 | SIGNOR-201530 |
| MTOR | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-55701 |
| MTOR | phosphorylation down-regulates | MAF1 | SIGNOR-165791 |
| MTOR | phosphorylation → up-regulates activity | MTOR | SIGNOR-75394 |
| MTOR | phosphorylation → down-regulates activity | IRS1 | SIGNOR-106590 |
| MTOR | phosphorylation → down-regulates activity | EIF4E | SIGNOR-278963 |
| MTOR | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-226714 |
| MTOR | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-55697 |
| MTOR | phosphorylation → down-regulates activity | IRS1 | SIGNOR-106578 |
| MTOR | phosphorylation → down-regulates activity | ULK1 | SIGNOR-183903 |
| MTOR | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-250292 |
| MTOR | phosphorylation → up-regulates activity | RPS6KB1 | SIGNOR-201534 |
| MTOR | phosphorylation down-regulates | DEPTOR | SIGNOR-176849 |
| MTOR | phosphorylation → down-regulates activity | AKT1S1 | SIGNOR-178128 |
| MTOR | phosphorylation → down-regulates activity | AMOTL2 | SIGNOR-272086 |
| MTOR | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-219266 |
| MTOR | phosphorylation → up-regulates activity | RPTOR | SIGNOR-184959 |
| MTOR | phosphorylation → up-regulates activity | RPS6KB1 | SIGNOR-101336 |
| MTOR | phosphorylation → up-regulates | STAT3 | SIGNOR-146915 |
| MTOR | phosphorylation → up-regulates activity | ESR1 | SIGNOR-278295 |
| MTOR | phosphorylation → up-regulates activity | ELP1 | SIGNOR-275541 |
| MTOR | phosphorylation → up-regulates activity | RPS6KB2 | SIGNOR-250294 |
| MTOR | phosphorylation → up-regulates activity | AKT | SIGNOR-134185 |
| MTOR | phosphorylation → up-regulates | SGK1 | SIGNOR-179113 |
| MTOR | phosphorylation → down-regulates activity | IRS1 | SIGNOR-52700 |
| MTOR | phosphorylation down-regulates | ULK2 | SIGNOR-183961 |
| MTOR | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-101115 |
| MTOR | phosphorylation → up-regulates activity | RPS6KB1 | SIGNOR-72682 |
| MTOR | phosphorylation down-regulates | EIF4EBP2 | SIGNOR-122014 |
| MTOR | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-219262 |
| MTOR | phosphorylation → up-regulates activity | AKT1 | SIGNOR-170604 |
| MTOR | phosphorylation → up-regulates | STAT3 | SIGNOR-161439 |
| MTOR | phosphorylation → up-regulates activity | RPS6KB1 | SIGNOR-201538 |
| MTOR | phosphorylation → up-regulates activity | UVRAG | SIGNOR-276919 |
| MTOR | phosphorylation → up-regulates activity | RPS6KB2 | SIGNOR-250295 |
| MTOR | phosphorylation down-regulates | MAF1 | SIGNOR-165795 |
| MTOR | phosphorylation → up-regulates | ISCU | SIGNOR-201595 |
| MTOR | phosphorylation → up-regulates activity | RPS6KB1 | SIGNOR-235507 |
| MTOR | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-154814 |
| MTOR | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-80797 |
| MTOR | phosphorylation → down-regulates activity | ULK1 | SIGNOR-172541 |
| MTOR | phosphorylation → up-regulates activity | RPS6KB2 | SIGNOR-250293 |
| MTOR | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-167184 |
| MTOR | phosphorylation down-regulates | MAF1 | SIGNOR-165799 |
| MTOR | phosphorylation → up-regulates activity | RPS6KB1 | SIGNOR-101332 |
| MTOR | phosphorylation → up-regulates activity | DNM1L | SIGNOR-275430 |
| MTOR | phosphorylation → down-regulates activity | DAP | SIGNOR-259812 |
| MTOR | phosphorylation → up-regulates activity | UVRAG | SIGNOR-276920 |
| MTOR | phosphorylation → up-regulates activity | RPS6KB1 | SIGNOR-72357 |
| MTOR | phosphorylation down-regulates | EIF4EBP2 | SIGNOR-199258 |
| MTOR | phosphorylation → down-regulates activity | ULK1 | SIGNOR-187611 |
| MTOR | phosphorylation → up-regulates activity | RPS6KB1 | SIGNOR-101328 |
| MTOR | phosphorylation → up-regulates | EIF4EBP3 | SIGNOR-122035 |
| MTOR | phosphorylation down-regulates | ATG13 | SIGNOR-183965 |
| MTOR | phosphorylation down-regulates | MAF1 | SIGNOR-166054 |
| MTOR | phosphorylation down-regulates | MAF1 | SIGNOR-164352 |
| MTOR | phosphorylation → down-regulates activity | IRS1 | SIGNOR-106574 |
| MTOR | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-154810 |