Summary

Name MTOR
Full Name Serine/threonine-protein kinase mTOR
Synonyms FK506-binding protein 12-rapamycin complex-associated protein 1, FKBP12-rapamycin complex-associated protein, Mammalian target of rapamycin, mTOR, Mechanistic target of rapamycin, Rapamycin and FKBP12 target 1, Rapamycin target protein 1 | FRAP, FRAP1, FRAP2, RAFT1, RAPT1
Primary ID P42345
Links - -
Type protein
Relations 157
Pathways Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, IDH-TET in AML, KIT in AML, miRNA in AML, FLT3-ITD in AML, FLT3-ITD signaling, Leptin Signaling, Mitochondrial dynamics in T cell exhaustion, MTOR Signaling, Parkinson, Rett syndrome, YAP/TAZ regulation
Inhibitors AP 23573; torin 2; Palomid 529; Temsirolimus; Ku-0063794; PP121; PKI-587; WAY-600; GSK1059615; torkinib; sirolimus; WYE-687; 4-[6-[4-(methoxycarbonylamino)phenyl]-4-(4-morpholinyl)-1-pyrazolo[3,4-d]pyrimidinyl]-1-piperidinecarboxylic acid methyl ester; AZD-8055; everolimus; XL765; 1-[4-[1-(1,4-dioxaspiro[4.5]decan-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-6-pyrazolo[3,4-d]pyrimidinyl]phenyl]-3-methylurea; 1-[4-[[2-(2-amino-5-pyrimidinyl)-7-methyl-4-(4-morpholinyl)-6-thieno[3,2-d]pyrimidinyl]methyl]-1-piperazinyl]-2-hydroxy-1-propanone; CH5132799
Function Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals (PubMed:12087098, PubMed:12150925, PubMed:12150926, PubMed:12231510, PubMed:12718876, PubMed:14651849, PubMed:15268862, PubMed:15467718, PubMed:15545625, PubMed:15718470, PubMed:18497260, PubMed:18762023, PubMed:18925875, PubMed:20516213, PubMed:20537536, PubMed:21659604, PubMed:23429703, PubMed:23429704, PubMed:25799227, PubMed:26018084). MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2) (PubMed:15268862, PubMed:15467718, PubMed:18925875, PubMed:18497260, PubMed:20516213, PubMed:21576368, PubMed:21659604, PubMed:23429704). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis (PubMed:12087098, PubMed:12150925, PubMed:12150926, PubMed:12231510, PubMed:12718876, PubMed:14651849, PubMed:15268862, PubMed:15467718, PubMed:15545625, PubMed:15718470, PubMed:18497260, PubMed:18762023, PubMed:18925875, PubMed:20516213, PubMed:20537536, PubMed:21659604, PubMed:23429703, PubMed:23429704, PubMed:25799227, PubMed:26018084). This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E) (By similarity). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4 (PubMed:12150925, PubMed:12087098, PubMed:18925875). This also includes mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation NRBF2 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ELP1 0.2
Publications: 1
+ up-regulates activity img/direct-activation.png phosphorylation MTOR 0.565
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, IDH-TET in AML, FLT3-ITD signaling, Leptin Signaling, MTOR Signaling
+ down-regulates activity img/direct_inhibition.png phosphorylation PRKN 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Parkinson
+ up-regulates img/direct-activation.png phosphorylation ISCU 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MTOR 0.513
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation TFEB 0.479
Publications: 2 Organism: Homo Sapiens
Pathways:MTOR Signaling
+ down-regulates activity img/direct_inhibition.png phosphorylation AKT1S1 0.905
Publications: 4 Organism: Homo Sapiens, In Vitro
Pathways:MTOR Signaling
+ up-regulates activity img/direct-activation.png phosphorylation MTOR 0.421
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation MTOR 0.2
Publications: 2 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling, Leptin Signaling
+ img/unknown.png phosphorylation MTOR 0.93
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling, Glioblastoma Multiforme, Parkinson
+ img/unknown.png phosphorylation MTOR 0.2
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, KIT in AML, miRNA in AML, FLT3-ITD in AML, FLT3-ITD signaling, Glioblastoma Multiforme, Leptin Signaling, MTOR Signaling, Pancreatic ductal adenocarcinoma (PDA)
+ up-regulates activity img/direct-activation.png phosphorylation MTOR 0.2
Publications: 2 Organism: Homo Sapiens, Mus Musculus
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, IDH-TET in AML, KIT in AML, miRNA in AML, FLT3-ITD in AML, FLT3-ITD signaling, Glioblastoma Multiforme, Leptin Signaling, MTOR Signaling, Parkinson, Pancreatic ductal adenocarcinoma (PDA), Rett syndrome
+ down-regulates img/direct_inhibition.png phosphorylation DEPTOR 0.755
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation DAP 0.396
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation IRS1 0.766
Publications: 7 Organism: Homo Sapiens, Rattus Norvegicus
Tissue: Kidney
Pathways:Leptin Signaling, MTOR Signaling
+ up-regulates activity img/direct-activation.png phosphorylation LARP6 0.2
Publications: 2 Organism: Rattus Norvegicus
+ up-regulates activity img/direct-activation.png phosphorylation RPS6KB2 0.834
Publications: 3 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation RPS6KB1 0.961
Publications: 10 Organism: Mus Musculus, Sus Scrofa, Homo Sapiens, In Vitro
Tissue: Parathyroid Hormone Secreting Cell
Pathways:FLT3-ITD signaling, MTOR Signaling
+ up-regulates img/direct-activation.png phosphorylation SGK1 0.849
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation AKT1 0.93
Publications: 3 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling, Glioblastoma Multiforme, Parkinson
+ up-regulates activity img/direct-activation.png phosphorylation AKT 0.93
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, KIT in AML, miRNA in AML, FLT3-ITD in AML, FLT3-ITD signaling, Glioblastoma Multiforme, Leptin Signaling, MTOR Signaling, Pancreatic ductal adenocarcinoma (PDA)
+ down-regulates activity img/direct_inhibition.png phosphorylation AMBRA1 0.473
Publications: 1
+ up-regulates activity img/direct-activation.png phosphorylation UVRAG 0.409
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MAF1 0.711
Publications: 6 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation DNM1L 0.346
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation EIF4EBP1 0.926
Publications: 18 Organism: Sus Scrofa, Homo Sapiens, Mus Musculus
Pathways:MTOR Signaling
+ up-regulates img/direct-activation.png phosphorylation STAT3 0.747
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, KIT in AML, FLT3-ITD signaling, Leptin Signaling, Pancreatic ductal adenocarcinoma (PDA)
+ down-regulates activity img/direct_inhibition.png phosphorylation MKNK2 0.274
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation ULK1 0.849
Publications: 3 Organism: Homo Sapiens
Pathways:MTOR Signaling
+ down-regulates activity img/direct_inhibition.png phosphorylation AMOTL2 0.2
Publications: 1
+ up-regulates activity img/direct-activation.png phosphorylation RPTOR 0.989
Publications: 4 Organism: Homo Sapiens
Pathways:MTOR Signaling
+ down-regulates activity img/direct_inhibition.png phosphorylation MTOR 0.961
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling, MTOR Signaling
+ up-regulates activity img/direct-activation.png phosphorylation RPS6K 0.539
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling, Leptin Signaling
+ up-regulates img/direct-activation.png phosphorylation RPS6KB2 0.834
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition MTOR 0.8
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates img/direct-activation.png relocalization MTOR 0.257
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png MTOR 0.848
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding mTORC2 0.73
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling, MTOR Signaling
+ down-regulates img/direct_inhibition.png binding MTOR 0.567
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png MTOR 0.332
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition MTOR 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition MTOR 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition MTOR 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png MTOR 0.565
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, IDH-TET in AML, FLT3-ITD signaling, Leptin Signaling, MTOR Signaling
+ up-regulates activity img/direct-activation.png binding MTOR 0.95
Publications: 2 Organism: Homo Sapiens
Pathways:MTOR Signaling
+ down-regulates activity img/direct_inhibition.png dephosphorylation MTOR 0.275
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition MTOR 0.8
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Smooth Muscle
+ up-regulates img/indirect-activation.png MTOR 0.637
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ up-regulates img/direct-activation.png relocalization MTOR 0.267
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation EIF4EBP2 0.66
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition MTOR 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition MTOR 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png MTOR 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, KIT in AML, miRNA in AML, FLT3-ITD in AML, FLT3-ITD signaling, Glioblastoma Multiforme, Leptin Signaling, MTOR Signaling, Pancreatic ductal adenocarcinoma (PDA)
+ up-regulates img/direct-activation.png phosphorylation MTOR 0.93
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:FLT3-ITD signaling, Glioblastoma Multiforme, Parkinson
+ down-regulates img/direct_inhibition.png chemical inhibition MTOR 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition MTOR 0.8
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding mTORC1 0.9
Publications: 1 Organism: Homo Sapiens
Pathways:Glioblastoma Multiforme, Pancreatic ductal adenocarcinoma (PDA)
+ down-regulates activity img/direct_inhibition.png chemical inhibition MTOR 0.8
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation MTOR 0.455
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition MTOR 0.8
Publications: 3 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ up-regulates img/indirect-activation.png Proliferation 0.7
Publications: 2 Organism: Homo Sapiens
Tissue: HEK-293 Cell, Skeletal Muscle
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, IDH-TET in AML, KIT in AML, miRNA in AML, FLT3-ITD in AML, FLT3-ITD signaling, Glioblastoma Multiforme, Leptin Signaling, Pancreatic ductal adenocarcinoma (PDA)
+ up-regulates img/indirect-activation.png MTOR 0.578
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, KIT in AML, FLT3-ITD in AML, FLT3-ITD signaling, Leptin Signaling, Pancreatic ductal adenocarcinoma (PDA)
+ down-regulates activity img/direct_inhibition.png binding MTOR 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition MTOR 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding MTOR 0.755
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png MTOR 0.705
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png MTOR 0.546
Publications: 1 Organism: Homo Sapiens
Pathways:Glioblastoma Multiforme, MTOR Signaling
+ down-regulates img/direct_inhibition.png chemical inhibition MTOR 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition MTOR 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png relocalization MTOR 0.811
Publications: 1 Organism: Homo Sapiens
Pathways:MTOR Signaling
+ down-regulates activity img/indirect_inhibition.png MTOR 0.777
Publications: 1 Organism: Homo Sapiens
Pathways:MTOR Signaling
+ down-regulates img/direct_inhibition.png chemical inhibition MTOR 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ULK2 0.776
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png ubiquitination MTOR 0.439
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Myotube_hypertrophy 0.7
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle, Myotube
+ up-regulates activity img/direct-activation.png phosphorylation ESR1 0.5
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ATG13 0.649
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition MTOR 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition MTOR 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition MTOR 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ down-regulates activity img/direct_inhibition.png MTOR 0.355
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation GRB10 0.414
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3 in AML, FLT3-ITD signaling
+ up-regulates activity img/direct-activation.png MTOR 0.4
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, miRNA in AML
+ down-regulates img/direct_inhibition.png chemical inhibition MTOR 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Neurogenesis 0.7
Publications: 1
Pathways:Rett syndrome
+ up-regulates img/direct-activation.png chemical activation MTOR 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition MTOR 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition MTOR 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation EIF4EBP3 0.359
Publications: 1 Organism: Homo Sapiens