Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
MTOR	MTOR	Ser2481 View in OncoXplorer	TVPESIHsFIGDGLV	phosphorylation up-regulates activity	20022946	SIGNOR-235427
ABL1	MTOR	–		phosphorylation down-regulates	10753870	SIGNOR-76562
AKT	MTOR	Thr2446	NKRSRTRtDSYSAGQ	phosphorylation unknown	10910062	SIGNOR-251482
RPS6K	MTOR	Thr2446	NKRSRTRtDSYSAGQ	phosphorylation down-regulates activity	15905173	SIGNOR-137255
AKT	MTOR	Ser2448 View in OncoXplorer	RSRTRTDsYSAGQSV	phosphorylation unknown	10910062	SIGNOR-244311
MTOR	MTOR	Ser2481 View in OncoXplorer	TVPESIHsFIGDGLV	phosphorylation up-regulates activity	10702316	SIGNOR-75394
DUSP16	MTOR	–		dephosphorylation down-regulates activity	25077541	SIGNOR-277067
TBK1	MTOR	Ser2159	RIQSIAPsLQVITSK	phosphorylation up-regulates activity	32854217	SIGNOR-278237
AMPK	MTOR	Ser1261 View in OncoXplorer	PMKKLHVsTINLQKA	phosphorylation up-regulates activity	31186373	SIGNOR-262535
AKT1	MTOR	Ser2448 View in OncoXplorer	RSRTRTDsYSAGQSV	phosphorylation unknown	10910062	SIGNOR-251099
CHUK	MTOR	Ser1415	PTPAILEsLISINNK	phosphorylation up-regulates activity	24990947	SIGNOR-276646
CHUK	MTOR	–		phosphorylation up-regulates activity	27027448	SIGNOR-279607
RPS6KB1	MTOR	Thr2446	NKRSRTRtDSYSAGQ	phosphorylation down-regulates activity	15905173	SIGNOR-102051
RPS6K	MTOR	Ser2448 View in OncoXplorer	RSRTRTDsYSAGQSV	phosphorylation down-regulates activity	15905173	SIGNOR-137251
AKT1	MTOR	–		phosphorylation up-regulates	15829723	SIGNOR-255107

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
MTOR	phosphorylation up-regulates →	MTOR PSer2481	phosphorylation up-regulates →	MTOR	20022946	SIGNOR-235427
AKT	phosphorylation up-regulates →	MTOR PThr2446	phosphorylation down-regulates ⊣	MTOR	10910062	SIGNOR-251482
RPS6K	phosphorylation up-regulates →	MTOR PThr2446	phosphorylation down-regulates ⊣	MTOR	15905173	SIGNOR-137255
AKT	phosphorylation up-regulates →	MTOR PSer2448	phosphorylation down-regulates ⊣	MTOR	10910062	SIGNOR-244311
MTOR	phosphorylation up-regulates →	MTOR PSer2481	phosphorylation up-regulates →	MTOR	10702316	SIGNOR-75394
TBK1	phosphorylation up-regulates →	MTOR PSer2159	phosphorylation up-regulates →	MTOR	32854217	SIGNOR-278237
AMPK	phosphorylation up-regulates →	MTOR PSer1261	phosphorylation up-regulates →	MTOR	31186373	SIGNOR-262535
AKT1	phosphorylation up-regulates →	MTOR PSer2448	phosphorylation down-regulates ⊣	MTOR	10910062	SIGNOR-251099
CHUK	phosphorylation up-regulates →	MTOR PSer1415	phosphorylation up-regulates →	MTOR	24990947	SIGNOR-276646
RPS6KB1	phosphorylation up-regulates →	MTOR PThr2446	phosphorylation down-regulates ⊣	MTOR	15905173	SIGNOR-102051
RPS6K	phosphorylation up-regulates →	MTOR PSer2448	phosphorylation down-regulates ⊣	MTOR	15905173	SIGNOR-137251

Regulator	Mechanism/Effect	Target	SIGNOR-ID
MTOR	phosphorylation → up-regulates activity	MTOR	SIGNOR-235427
ABL1	phosphorylation down-regulates	MTOR	SIGNOR-76562
AKT	phosphorylation → unknown	MTOR	SIGNOR-251482
RPS6K	phosphorylation → down-regulates activity	MTOR	SIGNOR-137255
AKT	phosphorylation → unknown	MTOR	SIGNOR-244311
MTOR	phosphorylation → up-regulates activity	MTOR	SIGNOR-75394
DUSP16	dephosphorylation → down-regulates activity	MTOR	SIGNOR-277067
TBK1	phosphorylation → up-regulates activity	MTOR	SIGNOR-278237
AMPK	phosphorylation → up-regulates activity	MTOR	SIGNOR-262535
AKT1	phosphorylation → unknown	MTOR	SIGNOR-251099
CHUK	phosphorylation → up-regulates activity	MTOR	SIGNOR-276646
CHUK	phosphorylation → up-regulates activity	MTOR	SIGNOR-279607
RPS6KB1	phosphorylation → down-regulates activity	MTOR	SIGNOR-102051
RPS6K	phosphorylation → down-regulates activity	MTOR	SIGNOR-137251
AKT1	phosphorylation → up-regulates	MTOR	SIGNOR-255107