| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPS6K | MTOR | Ser2448 | RSRTRTDsYSAGQSV | phosphorylation down-regulates activity | 15905173 | SIGNOR-137251 |
| AKT | MTOR | Ser2448 | RSRTRTDsYSAGQSV | phosphorylation unknown | 10910062 | SIGNOR-244311 |
| AKT1 | MTOR | Ser2448 | RSRTRTDsYSAGQSV | phosphorylation unknown | 10910062 | SIGNOR-251099 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPS6K | phosphorylation up-regulates → | MTOR PSer2448 | phosphorylation down-regulates ⊣ | MTOR | 15905173 | SIGNOR-137251 |
| AKT | phosphorylation up-regulates → | MTOR PSer2448 | phosphorylation down-regulates ⊣ | MTOR | 10910062 | SIGNOR-244311 |
| AKT1 | phosphorylation up-regulates → | MTOR PSer2448 | phosphorylation down-regulates ⊣ | MTOR | 10910062 | SIGNOR-251099 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| RPS6K | phosphorylation → down-regulates activity | MTOR | SIGNOR-137251 |
| AKT | phosphorylation → unknown | MTOR | SIGNOR-244311 |
| AKT1 | phosphorylation → unknown | MTOR | SIGNOR-251099 |
