| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT | MTOR | Thr2446 | NKRSRTRtDSYSAGQ | phosphorylation unknown | 10910062 | SIGNOR-251482 |
| RPS6K | MTOR | Thr2446 | NKRSRTRtDSYSAGQ | phosphorylation down-regulates activity | 15905173 | SIGNOR-137255 |
| RPS6KB1 | MTOR | Thr2446 | NKRSRTRtDSYSAGQ | phosphorylation down-regulates activity | 15905173 | SIGNOR-102051 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT | phosphorylation up-regulates → | MTOR PThr2446 | phosphorylation down-regulates ⊣ | MTOR | 10910062 | SIGNOR-251482 |
| RPS6K | phosphorylation up-regulates → | MTOR PThr2446 | phosphorylation down-regulates ⊣ | MTOR | 15905173 | SIGNOR-137255 |
| RPS6KB1 | phosphorylation up-regulates → | MTOR PThr2446 | phosphorylation down-regulates ⊣ | MTOR | 15905173 | SIGNOR-102051 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT | phosphorylation → unknown | MTOR | SIGNOR-251482 |
| RPS6K | phosphorylation → down-regulates activity | MTOR | SIGNOR-137255 |
| RPS6KB1 | phosphorylation → down-regulates activity | MTOR | SIGNOR-102051 |
