| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP2R5B | CASP3 | Ser150 | FRGDRCRsLTGKPKL | dephosphorylation up-regulates | 15569672 | SIGNOR-131435 |
| MAPK14 | CASP3 | Ser150 | FRGDRCRsLTGKPKL | phosphorylation down-regulates | 14970175 | SIGNOR-122099 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP2R5B | dephosphorylation down-regulates ⊣ | CASP3 PSer150 | dephosphorylation down-regulates ⊣ | CASP3 | 15569672 | SIGNOR-131435 |
| MAPK14 | phosphorylation up-regulates → | CASP3 PSer150 | phosphorylation down-regulates ⊣ | CASP3 | 14970175 | SIGNOR-122099 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPP2R5B | dephosphorylation → up-regulates | CASP3 | SIGNOR-131435 |
| MAPK14 | phosphorylation down-regulates | CASP3 | SIGNOR-122099 |
