Summary

Name CASP3
Full Name Caspase-3
Synonyms CASP-3, Apopain, Cysteine protease CPP32, CPP-32, Protein Yama, SREBP cleavage activity 1, SCA-1 | CPP32
Primary ID P42574
Links - -
Type protein
Relations 75
Pathways Alzheimer, COVID-19 Causal Network, Death Receptor Signaling, Inhibition of Apoptosis, Mitochondrial Control of Apoptosis, Myofiber: IL6 and atrophy, Parkinson, SARS-COV APOPTOSIS, TNF-alpha Signaling
Function Involved in the activation cascade of caspases responsible for apoptosis execution (PubMed:7596430). At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond (PubMed:7774019). Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9 (PubMed:7596430). Involved in the cleavage of huntingtin (PubMed:8696339). Triggers cell adhesion in sympathetic neurons through RET cleavage (PubMed:21357690). Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress (PubMed:23152800).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates quantity by destabilization img/direct_inhibition.png cleavage BRCA1 0.489
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png cleavage PTCH1 0.33
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png cleavage PTCH1 0.33
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png cleavage IKBKB 0.377
Publications: 4 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png cleavage GAS2 0.424
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png cleavage GORASP1 0.406
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png cleavage STK4 0.595
Publications: 2 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png cleavage PSEN2 0.417
Publications: 2 Organism: In Vitro
Pathways:Alzheimer
+ up-regulates activity img/direct-activation.png cleavage CASP9 0.617
Publications: 2 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Death Receptor Signaling, Inhibition of Apoptosis, Mitochondrial Control of Apoptosis, Parkinson, SARS-COV APOPTOSIS
+ up-regulates activity img/direct-activation.png cleavage PSEN1 0.47
Publications: 1 Organism: In Vitro
Pathways:Alzheimer
+ up-regulates activity img/direct-activation.png cleavage GORASP1 0.406
Publications: 1
+ down-regulates activity img/direct_inhibition.png cleavage GSN 0.622
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png cleavage MYL3 0.386
Publications: 1 Organism: Oryctolagus Cuniculus
+ up-regulates img/direct-activation.png dephosphorylation CASP3 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CASP3 0.766
Publications: 1 Organism: Homo Sapiens
Pathways:TNF-alpha Signaling
+ down-regulates activity img/direct_inhibition.png cleavage AKT 0.668
Publications: 1 Organism: In Vitro
Pathways:COVID-19 Causal Network, Inhibition of Apoptosis, SARS-COV APOPTOSIS
+ up-regulates img/indirect-activation.png Muscle_atrophy 0.7
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png cleavage PSIP1 0.355
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png cleavage CASP3 0.617
Publications: 2 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Death Receptor Signaling, Inhibition of Apoptosis, Mitochondrial Control of Apoptosis, Parkinson, SARS-COV APOPTOSIS
+ down-regulates img/indirect_inhibition.png CASP3 0.588
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CASP3 0.482
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png binding CASP3 0.505
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding CASP3 0.48
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png cleavage CASP3 0.617
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Membrane_blebbing 0.7
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates activity img/indirect_inhibition.png CASP3 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png DNA_fragmentation 0.7
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding Caspase 3 complex 0.2
Publications: 1
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CASP3 0.267
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png cleavage CASP3 0.729
Publications: 2 Organism: Homo Sapiens
Pathways:Alzheimer
+ down-regulates activity img/direct_inhibition.png cleavage AKT1 0.629
Publications: 1 Organism: In Vitro
Pathways:Parkinson
+ up-regulates activity img/indirect-activation.png CASP3 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png cleavage CASP3 0.707
Publications: 3 Organism: Homo Sapiens, Mus Musculus
+ down-regulates activity img/direct_inhibition.png cleavage KDM4C 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png cleavage GRIPAP1 0.426
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png cleavage CASP6 0.595
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-COV APOPTOSIS
+ up-regulates img/direct-activation.png cleavage DFFB 0.672
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png cleavage CASP3 0.707
Publications: 3 Organism: Homo Sapiens, Mus Musculus
Pathways:Alzheimer, COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, SARS-COV APOPTOSIS, TNF-alpha Signaling
+ up-regulates img/direct-activation.png chemical activation CASP3 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png ubiquitination CASP3 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CASP3 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png cleavage NFKBIA 0.437
Publications: 1 Organism: In Vitro
Pathways:COVID-19 Causal Network, Inhibition of Apoptosis, TNF-alpha Signaling
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination CASP3 0.938
Publications: 1 Organism: Homo Sapiens
Pathways:Death Receptor Signaling, Inhibition of Apoptosis, Parkinson
+ up-regulates activity img/direct-activation.png cleavage BAD 0.515
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Inhibition of Apoptosis, Mitochondrial Control of Apoptosis, SARS-COV APOPTOSIS
+ up-regulates activity img/direct-activation.png cleavage DFFA 0.744
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Cell_death 0.7
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png cleavage RAD51 0.48
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png cleavage SPTAN1 0.659
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png cleavage PARP1 0.767
Publications: 1 Organism: Mus Musculus
Pathways:COVID-19 Causal Network, Death Receptor Signaling, Inhibition of Apoptosis, Mitochondrial Control of Apoptosis, SARS-COV APOPTOSIS, TNF-alpha Signaling
+ up-regulates img/indirect-activation.png Apoptosis 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:Alzheimer, COVID-19 Causal Network, Death Receptor Signaling, Inhibition of Apoptosis, Mitochondrial Control of Apoptosis, Parkinson, SARS-COV APOPTOSIS, TNF-alpha Signaling
+ up-regulates img/direct-activation.png cleavage ROCK1 0.723
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation CASP3 0.8
Publications: 1 Organism: In Vitro
+ up-regulates img/indirect-activation.png Chromatine_condensation 0.7
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates activity img/direct_inhibition.png binding CASP3 0.938
Publications: 2 Organism: Homo Sapiens
Pathways:Death Receptor Signaling, Inhibition of Apoptosis, Parkinson
+ down-regulates img/direct_inhibition.png cleavage GSN 0.622
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CASP3 0.262
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Protein_degradation 0.7
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png cleavage ACIN1 0.609
Publications: 1 Organism: Homo Sapiens