| Name | CASP2 |
| ID | P42575 |
| Role | substrate |
| Enzymatic Domains |
CARD 32-121 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP1CA | CASP2 | Ser164 | STDTVEHsLDNKDGP | dephosphorylation up-regulates activity | 19531356 | SIGNOR-248564 |
| PP1 | CASP2 | Ser164 | STDTVEHsLDNKDGP | dephosphorylation up-regulates activity | 19531356 | SIGNOR-264661 |
| PRKDC | CASP2 | Ser139 | LSCDYDLsLPFPVCE | phosphorylation up-regulates | 19203584 | SIGNOR-183895 |
| PPP1CC | CASP2 | Ser164 | STDTVEHsLDNKDGP | dephosphorylation up-regulates activity | 19531356 | SIGNOR-248503 |
| AURKB | CASP2 | Ser384 | MRNTKRGsWYIEALA | phosphorylation up-regulates activity | 32811973 | SIGNOR-279496 |
| PPP1CB | CASP2 | Ser164 | STDTVEHsLDNKDGP | dephosphorylation up-regulates activity | 19531356 | SIGNOR-248576 |
| CSNK2A1 | CASP2 | Ser157 | LYKKLRLsTDTVEHS | phosphorylation down-regulates | 16193064 | SIGNOR-140836 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP1CA | dephosphorylation down-regulates ⊣ | CASP2 PSer164 | dephosphorylation down-regulates ⊣ | CASP2 | 19531356 | SIGNOR-248564 |
| PP1 | dephosphorylation down-regulates ⊣ | CASP2 PSer164 | dephosphorylation down-regulates ⊣ | CASP2 | 19531356 | SIGNOR-264661 |
| PRKDC | phosphorylation up-regulates → | CASP2 PSer139 | phosphorylation up-regulates → | CASP2 | 19203584 | SIGNOR-183895 |
| PPP1CC | dephosphorylation down-regulates ⊣ | CASP2 PSer164 | dephosphorylation down-regulates ⊣ | CASP2 | 19531356 | SIGNOR-248503 |
| AURKB | phosphorylation up-regulates → | CASP2 PSer384 | phosphorylation up-regulates → | CASP2 | 32811973 | SIGNOR-279496 |
| PPP1CB | dephosphorylation down-regulates ⊣ | CASP2 PSer164 | dephosphorylation down-regulates ⊣ | CASP2 | 19531356 | SIGNOR-248576 |
| CSNK2A1 | phosphorylation up-regulates → | CASP2 PSer157 | phosphorylation down-regulates ⊣ | CASP2 | 16193064 | SIGNOR-140836 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPP1CA | dephosphorylation → up-regulates activity | CASP2 | SIGNOR-248564 |
| PP1 | dephosphorylation → up-regulates activity | CASP2 | SIGNOR-264661 |
| PRKDC | phosphorylation → up-regulates | CASP2 | SIGNOR-183895 |
| PPP1CC | dephosphorylation → up-regulates activity | CASP2 | SIGNOR-248503 |
| AURKB | phosphorylation → up-regulates activity | CASP2 | SIGNOR-279496 |
| PPP1CB | dephosphorylation → up-regulates activity | CASP2 | SIGNOR-248576 |
| CSNK2A1 | phosphorylation down-regulates | CASP2 | SIGNOR-140836 |