Summary

Name CASP2
Full Name Caspase-2
Synonyms CASP-2, Neural precursor cell expressed developmentally down-regulated protein 2, NEDD-2, Protease ICH-1 | ICH1, NEDD2
Primary ID P42575
Links - -
Type protein
Relations 10
Function Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival (PubMed:15073321). Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress (PubMed:15073321).

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation CASP2 0.304
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CASP2 0.313
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation CASP2 0.2
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png dephosphorylation CASP2 0.2
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png dephosphorylation CASP2 0.2
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png dephosphorylation CASP2 0.2
Publications: 1 Organism: In Vitro
+ form complex img/form-complex.png binding Caspase 2 complex 0.2
Publications: 1
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CASP2 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding CASP2 0.516
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding Caspase-2 PIDDosome 0.857
Publications: 1 Organism: Homo Sapiens