| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP1CC | CASP2 | Ser164 | STDTVEHsLDNKDGP | dephosphorylation up-regulates activity | 19531356 | SIGNOR-248503 |
| PPP1CB | CASP2 | Ser164 | STDTVEHsLDNKDGP | dephosphorylation up-regulates activity | 19531356 | SIGNOR-248576 |
| PPP1CA | CASP2 | Ser164 | STDTVEHsLDNKDGP | dephosphorylation up-regulates activity | 19531356 | SIGNOR-248564 |
| PP1 | CASP2 | Ser164 | STDTVEHsLDNKDGP | dephosphorylation up-regulates activity | 19531356 | SIGNOR-264661 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP1CC | dephosphorylation down-regulates ⊣ | CASP2 PSer164 | dephosphorylation down-regulates ⊣ | CASP2 | 19531356 | SIGNOR-248503 |
| PPP1CB | dephosphorylation down-regulates ⊣ | CASP2 PSer164 | dephosphorylation down-regulates ⊣ | CASP2 | 19531356 | SIGNOR-248576 |
| PPP1CA | dephosphorylation down-regulates ⊣ | CASP2 PSer164 | dephosphorylation down-regulates ⊣ | CASP2 | 19531356 | SIGNOR-248564 |
| PP1 | dephosphorylation down-regulates ⊣ | CASP2 PSer164 | dephosphorylation down-regulates ⊣ | CASP2 | 19531356 | SIGNOR-264661 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPP1CC | dephosphorylation → up-regulates activity | CASP2 | SIGNOR-248503 |
| PPP1CB | dephosphorylation → up-regulates activity | CASP2 | SIGNOR-248576 |
| PPP1CA | dephosphorylation → up-regulates activity | CASP2 | SIGNOR-248564 |
| PP1 | dephosphorylation → up-regulates activity | CASP2 | SIGNOR-264661 |
