| Name | ABL2 |
| ID | P42684 |
| Role | kinase |
| Enzymatic Domains |
SH3 107-167 PROSITE-ProRule
SH2 173-263 PROSITE-ProRule
Protein kinase 288-539 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ABL2 | PSMA7 | Tyr153 | QTDPSGTyHAWKANA | phosphorylation down-regulates | 16678104 | SIGNOR-146589 |
| ABL2 | SIVA1 | Tyr34 | RGVCAERySQEVFEK | phosphorylation up-regulates | 11278261 | SIGNOR-104992 |
| ABL2 | CAT | Tyr231 | NANGEAVyCKFHYKT | phosphorylation up-regulates | 12950161 | SIGNOR-86680 |
| ABL2 | CAT | Tyr386 | YRARVANyQRDGPMC | phosphorylation up-regulates | 12950161 | SIGNOR-86684 |
| ABL2 | CAT | Tyr231 | NANGEAVyCKFHYKT | phosphorylation up-regulates activity | 12777400 | SIGNOR-260771 |
| ABL2 | CAT | Tyr231 | NANGEAVyCKFHYKT | phosphorylation up-regulates activity | 12777400 | SIGNOR-101306 |
| ABL2 | CAT | Tyr386 | YRARVANyQRDGPMC | phosphorylation up-regulates activity | 12777400 | SIGNOR-260772 |
| ABL2 | CAT | Tyr386 | YRARVANyQRDGPMC | phosphorylation up-regulates activity | 12777400 | SIGNOR-101310 |
| ABL2 | GPX1 | Tyr98 | EILNSLKyVRPGGGF | phosphorylation up-regulates activity | 12893824 | SIGNOR-104328 |
| ABL2 | PDGFRB | Tyr686 | IITEYCRyGDLVDYL | phosphorylation up-regulates activity | 19275932 | SIGNOR-276140 |
| ABL2 | CEBPB | Tyr78 | RAIDFSPyLEPLGAP | phosphorylation up-regulates | 19563810 | SIGNOR-186427 |
| ABL2 | LGALS3 | Tyr118 | AGPLIVPyNLPLPGG | phosphorylation up-regulates | 20150913 | SIGNOR-163743 |
| ABL2 | LGALS3 | Tyr79 | GAPAPGVyPGPPSGP | phosphorylation up-regulates | 20150913 | SIGNOR-163747 |
| ABL2 | ABL2 | Tyr439 | RLMTGDTyTAHAGAK | phosphorylation down-regulates quantity by destabilization | 15735735 | SIGNOR-276032 |
| ABL2 | ABL2 | Tyr261 | GLVTTLHyPAPKCNK | phosphorylation up-regulates | 15735735 | SIGNOR-134400 |
| ABL2 | ABL2 | Tyr261 | GLVTTLHyPAPKCNK | phosphorylation up-regulates quantity by stabilization | 15735735 | SIGNOR-276033 |
| ABL2 | CRK | Tyr221 | GGPEPGPyAQPSVNT | phosphorylation down-regulates | 15886098 | SIGNOR-136955 |
| ABL2 | CRK | – | phosphorylation down-regulates | 15886098 | SIGNOR-136958 | |
| ABL2 | RIN1 | – | phosphorylation up-regulates activity | 15886098 | SIGNOR-279676 | |
| ABL2 | IRF3 | Tyr292 | RLGHCHTyWAVSEEL | phosphorylation up-regulates activity | 30842273 | SIGNOR-277441 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ABL2 | phosphorylation up-regulates → | PSMA7 PTyr153 | phosphorylation down-regulates ⊣ | PSMA7 | 16678104 | SIGNOR-146589 |
| ABL2 | phosphorylation up-regulates → | SIVA1 PTyr34 | phosphorylation up-regulates → | SIVA1 | 11278261 | SIGNOR-104992 |
| ABL2 | phosphorylation up-regulates → | CAT PTyr231 | phosphorylation up-regulates → | CAT | 12950161 | SIGNOR-86680 |
| ABL2 | phosphorylation up-regulates → | CAT PTyr386 | phosphorylation up-regulates → | CAT | 12950161 | SIGNOR-86684 |
| ABL2 | phosphorylation up-regulates → | CAT PTyr231 | phosphorylation up-regulates → | CAT | 12777400 | SIGNOR-260771 |
| ABL2 | phosphorylation up-regulates → | CAT PTyr231 | phosphorylation up-regulates → | CAT | 12777400 | SIGNOR-101306 |
| ABL2 | phosphorylation up-regulates → | CAT PTyr386 | phosphorylation up-regulates → | CAT | 12777400 | SIGNOR-260772 |
| ABL2 | phosphorylation up-regulates → | CAT PTyr386 | phosphorylation up-regulates → | CAT | 12777400 | SIGNOR-101310 |
| ABL2 | phosphorylation up-regulates → | GPX1 PTyr98 | phosphorylation up-regulates → | GPX1 | 12893824 | SIGNOR-104328 |
| ABL2 | phosphorylation up-regulates → | PDGFRB PTyr686 | phosphorylation up-regulates → | PDGFRB | 19275932 | SIGNOR-276140 |
| ABL2 | phosphorylation up-regulates → | CEBPB PTyr78 | phosphorylation up-regulates → | CEBPB | 19563810 | SIGNOR-186427 |
| ABL2 | phosphorylation up-regulates → | LGALS3 PTyr118 | phosphorylation up-regulates → | LGALS3 | 20150913 | SIGNOR-163743 |
| ABL2 | phosphorylation up-regulates → | LGALS3 PTyr79 | phosphorylation up-regulates → | LGALS3 | 20150913 | SIGNOR-163747 |
| ABL2 | phosphorylation up-regulates → | ABL2 PTyr439 | phosphorylation down-regulates ⊣ | ABL2 | 15735735 | SIGNOR-276032 |
| ABL2 | phosphorylation up-regulates → | ABL2 PTyr261 | phosphorylation up-regulates → | ABL2 | 15735735 | SIGNOR-134400 |
| ABL2 | phosphorylation up-regulates → | ABL2 PTyr261 | phosphorylation up-regulates → | ABL2 | 15735735 | SIGNOR-276033 |
| ABL2 | phosphorylation up-regulates → | CRK PTyr221 | phosphorylation down-regulates ⊣ | CRK | 15886098 | SIGNOR-136955 |
| ABL2 | phosphorylation up-regulates → | IRF3 PTyr292 | phosphorylation up-regulates → | IRF3 | 30842273 | SIGNOR-277441 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ABL2 | phosphorylation down-regulates | PSMA7 | SIGNOR-146589 |
| ABL2 | phosphorylation → up-regulates | SIVA1 | SIGNOR-104992 |
| ABL2 | phosphorylation → up-regulates | CAT | SIGNOR-86680 |
| ABL2 | phosphorylation → up-regulates | CAT | SIGNOR-86684 |
| ABL2 | phosphorylation → up-regulates activity | CAT | SIGNOR-260771 |
| ABL2 | phosphorylation → up-regulates activity | CAT | SIGNOR-101306 |
| ABL2 | phosphorylation → up-regulates activity | CAT | SIGNOR-260772 |
| ABL2 | phosphorylation → up-regulates activity | CAT | SIGNOR-101310 |
| ABL2 | phosphorylation → up-regulates activity | GPX1 | SIGNOR-104328 |
| ABL2 | phosphorylation → up-regulates activity | PDGFRB | SIGNOR-276140 |
| ABL2 | phosphorylation → up-regulates | CEBPB | SIGNOR-186427 |
| ABL2 | phosphorylation → up-regulates | LGALS3 | SIGNOR-163743 |
| ABL2 | phosphorylation → up-regulates | LGALS3 | SIGNOR-163747 |
| ABL2 | phosphorylation down-regulates quantity by destabilization | ABL2 | SIGNOR-276032 |
| ABL2 | phosphorylation → up-regulates | ABL2 | SIGNOR-134400 |
| ABL2 | phosphorylation → up-regulates quantity by stabilization | ABL2 | SIGNOR-276033 |
| ABL2 | phosphorylation down-regulates | CRK | SIGNOR-136955 |
| ABL2 | phosphorylation down-regulates | CRK | SIGNOR-136958 |
| ABL2 | phosphorylation → up-regulates activity | RIN1 | SIGNOR-279676 |
| ABL2 | phosphorylation → up-regulates activity | IRF3 | SIGNOR-277441 |